Antiprotozoal Activities of Heterocyclic-Substituted Xanthones from the Marine-Derived Fungus <i>Chaetomium</i> sp.

The genus Chaetomium fungi are considered to be a rich source of novel and bioactive secondary metabolites of great importance. Up till now, a variety of more than 200 secondary metabolites belonging to diverse structural types of chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinones, chromones, depsidones, terpenoids, and steroids have been discovered. Most of these fungal metabolites exhibited antitumor, cytotoxic, antimalarial, enzyme inhibitory, antibiotic, and other activities. This review covers the extraction, structure elucidation, structural diversity, and biological activities of natural products isolated from about 30 fungi associated with marine- and terrestrial- origins, and highlights some bioactive compounds as well as their mechanisms of action and structure-activity relationships.

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“…[104]. Compounds 135 and 136 possess a rare dioxane/ tetrahydropyran moiety, and 137 was a chlorinated xanthone with a tetrahydropyran ring.…”

Section: Xanthones and Anthraquinonesmentioning

confidence: 99%

Chemical and Bioactive Diversities of the Genus Chaetomium Secondary Metabolites

Zhang

Li²,

Zong³

et al. 2012

MRMC

117

102

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“…7 In recent years, xanthones and xanthone derivatives have been reported to have significant pharmacological activities based on their diverse structures. [8][9][10][11][12][13][14][15][16][17][18][19][20] Their interesting structural scaffold and the significant biological activities have led many scientists to isolate, modify or synthesize different xanthones for the development of prospective new drug candidates. 7 Many xanthones bearing nitrogenated side chains connected to the phenolic core in different positions by C, O or N atoms have been synthesized during the last 10 years, and this group of molecules have showed interesting biological effects 14,18,[21][22][23][24][25] including antibacterial 26 and cytotoxic activities.…”

Section: Introductionmentioning

confidence: 99%

Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines

Micheletti¹,

Honda²,

Lima³

et al. 2011

Quím. Nova

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A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.

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“…[106][107][108]120, and 121 were assayed for cancer chemopreventive activity through modulating drug-metabolizing enzymes, including cytochrome P-450 1A (CYP1A) and quinone reductase (QR). As a result, 98 outstood as the most active inhibitor of CYP1A with an IC 50 value of 3.0 μM, and 106 required a concentration of 5.3 μM to double the specific activity of QR Pontius et al 2008bPontius et al , 2008c Plasmodium falciparum with an IC 50 value of 0.5 μg/mL (1.4 μM), and 114 inhibited Trypanosoma cruzi with an IC 50 value of 1.5 μg/mL (3.8 μM) (Pontius et al 2008a). …”

Section: Structure and Bioactivity Polyketidesmentioning

confidence: 99%

Mycochemistry of marine algicolous fungi

Wang

2016

Fungal Diversity

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Marine algicolous fungi refer to the fungi inhabiting or associated with marine algae, which have attracted a great attention for natural product researchers due to their chemical diversity and biological activity during the past two decades. Up to the end of 2014, a total of 366 new natural products, including polyketides, terpenoids, polyketide-terpenoids, peptides, alkaloids, and shikimate derivatives, have been characterized from them. Among these metabolites, 240 compounds feature cytotoxic, antibacterial, antifungal, antimicroalgal, zooplankton-toxic, antiprotozoal, antioxidative, enzyme-modulatory, and/or some other activities. This review gives a comprehensive coverage of both chemical and biological aspects of the secondary metabolites from marine algicolous fungi.

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Antiprotozoal Activities of Heterocyclic-Substituted Xanthones from the Marine-Derived Fungus Chaetomium sp.

Cited by 83 publications

References 30 publications

Chemical and Bioactive Diversities of the Genus Chaetomium Secondary Metabolites

Chemical and Bioactive Diversities of the Genus Chaetomium Secondary Metabolites

Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines

Mycochemistry of marine algicolous fungi

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