volume 93, issue 0, P3-O-112 2020
DOI: 10.1254/jpssuppl.93.0_3-o-112
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Abstract: We previously reported that silencing of the PRR gene, which encodes the (pro)renin receptor ((P)RR) significantly reduced Wnt/β-catenin-dependent development of pancreatic ductal adenocarcinoma (PDAC). Here, we examined the effects of a panel of blocking monoclonal antibodies (mAbs) directed against the (P)RR extracellular domain on proliferation of the human PDAC cell lines PK-1 and PANC-1 in vitro and in vivo. We observed that four rat anti-(P) RR mAbs induced accumulation of cells in the G0/G1 phase of the…

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