Antiproliferative and Apoptotic Potential of Cyanidin-Based Anthocyanins on Melanoma Cells

Rugină, Dumitriţa; Hanganu, Daniela; Diaconeasa, Zorița; Tăbăran, Flaviu; Coman, Cristina; Leopold, Loredana; Bunea, Andrea; Pintea, Adela

doi:10.3390/ijms18050949

Cited by 28 publications

(20 citation statements)

References 29 publications

(41 reference statements)

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“…To find an effective natural compound that inhibits the NF-κB signaling pathway, IKKβ kinase activity was analyzed with an in-house natural product library, and CyCl was found as a potential candidate for reducing IKKβ phosphorylation. Recently, an anthocyanins-enriched extract from elderberries, in which five cyanidin-based anthocyanins were identified, inhibited proliferation and induced apoptosis in melanoma cells [33]. Cyanidin-3-O-glucoside, a cyanidin derivative, inhibited NF-κB signaling molecules and had a protective effect through activation of the Nrf2 pathway in intestinal epithelial cells exposed to TNF-α [34].…”

Section: Discussionmentioning

confidence: 99%

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells

et al. 2020

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Colorectal cancer (CRC) is the third most common cancer worldwide and a leading cause of cancer-related deaths in developed countries. Anthocyanins are a class of flavonoids, widely distributed in food, exhibiting important biological effects. Cyanidin chloride (CyCl) is the common type of anthocyanin with antioxidative and anti-inflammatory potential. The present study aimed to investigate the molecular mechanisms underlying the chemotherapeutic effects of CyCl in colorectal cancer cells. We found that CyCl treatment induced apoptosis as well as a significant inhibition of cellular proliferation and colony formation in three colon cancer HCT116, HT29, and SW620 cells. In addition, CyCl suppressed nuclear factor-kappa B (NF-κB) signaling and induced the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in tumor necrosis factor-alpha (TNF-α)-stimulated colon cancer cells. Nrf2 and NF-κB are two key transcription factors regulating antioxidative responses and cellular proliferation, respectively. In this study, knockdown of Nrf2 by small interfering RNA (siRNA) transfection inhibited the effect of CyCl on NF-κB signaling and apoptosis, suggesting that there is functional crosstalk between Nrf2 and NF-κB. Our findings demonstrate the important role of Nrf2 in inducing apoptosis through the involvement of NF-κB signaling in colorectal cancer cells, suggesting that CyCl may be used as a potential therapeutic agent for CRC.

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Section: Discussionmentioning

confidence: 99%

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells

et al. 2020

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“…activation via loss of mitochondrial membrane potential [81]. Many other studies have also proved the antiproliferative and proapoptotic effects of anthocyanins on melanoma or others skin diseases [82][83][84]. Our latest published revealed that anthocyanins may inhibit melanoma cell proliferation, increase the level of oxidative stress, and diminished mitochondrial membrane potential [84].…”

Section: Skin Cancermentioning

confidence: 95%

“…Reactive oxygen species (ROS) are produced by all aerobic cells and are important to the immune system, cell signaling, and many other normal body functions. They can elicit cellular damage, leading to degenerative diseases such as inflammation, cardiovascular disease, cancer, and aging if ROS are excessively produced [33][34][35]. As we mention previously, anthocyanins are potent antioxidants and their effectiveness has been tested in vitro and in vivo.…”

Section: Anthocyanins' Potential Health Benefitsmentioning

confidence: 99%

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Anthocyanins-Smart Molecules for Cancer Prevention

Diaconeasa¹,

Frond²,

Ştirbu³

et al. 2018

Phytochemicals - Source of Antioxidants and Role in Disease Prevention

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Anthocyanins are one of the most widespread natural pigments in the plant kingdom. Being surrounded by so many fruits and vegetables rich in anthocyanins, it is recommended to consume a relatively large amount of them. A daily intake of anthocyanins has a certain demonstrated benefits: lowers the risk of cardiovascular disease, diabetes, arthritis, and cancer due, at least in part, to their antioxidant and anti-inflammatory activities. Lately, great attention is paid to their anticancer properties due to the need for user-friendly approaches to improve the treatment. So far, cancer had been nominated to be the second in top 10 diseases of the twenty-first century. Those colorful pigments have the ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression and can also inhibit the growth of cancer cells. However, the main concern related to the use of anthocyanins as anticancer agents is their poor bioavailability, more specific poor absorption, and biodistribution. In this chapter, the anticancer activities of anthocyanins or anthocyanin-rich extracts in vitro or in vivo were reviewed.

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“…Also, apoptosis is the mechanism through which many anti-cancer treatments, including melanoma treatments, work. Some common cosmetic ingredients, such as elderberry extract, can enhance effectivity of cancer treatment by enhancing apoptosis in malignant cells [ 47 ].…”

Section: Ghk and Gene Expressionmentioning

confidence: 99%

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

Pickart¹,

Margolina²

2018

IJMS

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The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.

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Antiproliferative and Apoptotic Potential of Cyanidin-Based Anthocyanins on Melanoma Cells

Cited by 28 publications

References 29 publications

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells

Anthocyanins-Smart Molecules for Cancer Prevention

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

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