Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone

Seo, Eun Ji; Lee, Dong‐Ung; Kwak, Jong Hwan; Lee, Sun-Mee; Kim, Yeong Shik; Jung, Yi‐Sook

doi:10.1016/j.jep.2011.02.025

Cited by 88 publications

(51 citation statements)

References 43 publications

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“…Platelet-rich plasma (PRP) was prepared as described previously (14). Briefly, SD rats, weighing 200 -250 g, were lightly anesthetized with diethyl ether.…”

Section: Preparation Of Plateletsmentioning

confidence: 99%

“…Platelet aggregation studies were performed under the experimental setting described in previous studies (14,15) using the turbidimetric method described by Mustard et al (16). Briefly, PRP was stimulated with different aggregating agents at the following final concentrations: collagen, 2 μg/mL; thrombin, 0.4 U/mL; AA, 100 μM; or ADP, 10 μM.…”

Section: In Vitro Platelet Aggregation Studymentioning

confidence: 99%

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Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

et al. 2012

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Abstract. Rhubarb is a widely used traditional medicine and has been reported to elicit a number of biological effects including anti-inflammatory and antiplatelet effects. In the present study, we investigated the effects of anthraquinone derivatives isolated from rhubarb on platelet activity. Of four anthraquinone derivatives isolated from rhubarb examined, chrysophanol-8-O-glucoside (CP-8-O-glc) was found to have the most potent inhibitory effect on collagen-and thrombin-induced platelet aggregation. CP-8-O-glc-treated mice showed significantly prolonged bleeding times. Furthermore, CP-8-O-glc was found to have a significant inhibitory effect on rat platelet aggregation ex vivo and on thromboxane A 2 formation in vitro. In coagulation tests, CP-8-O-glc did not alter prothrombin time, and it prolonged the activated partial thromboplastin time. However, CP-8-O-glc only inhibited platelet phosphatidylserine exposure, but not exert direct inhibition on intrinsic factors. This study demonstrates the antiplatelet and anticoagulant effects of CP-8-O-glc and suggests that this compound might be of therapeutic benefit for the prevention of plateletrelated cardiovascular diseases.

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“…Platelet-rich plasma (PRP) was prepared as described previously (14). Briefly, SD rats, weighing 200 -250 g, were lightly anesthetized with diethyl ether.…”

Section: Preparation Of Plateletsmentioning

confidence: 99%

Section: In Vitro Platelet Aggregation Studymentioning

confidence: 99%

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

et al. 2012

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“…Jin et al (2011) reported that sesquiterpenes prepared from a 70% ethanol extract of the rhizomes of C. rotundus exerted significant anti-allergic activity in vitro and in vivo. Nootkatone, a sesquiterpene isolated from C. rotundus, was found to have potent inhibitory effects on collagen-, thrombin-and arachidonic acid-induced platelet aggregation (Seo et al, 2011). The antidiabetic activity of C. rotundus has also been evaluated in animal models.…”

Section: Introductionmentioning

confidence: 99%

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Tran

Nguyen

et al. 2013

Pharmaceutical Biology

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Context: A methanol extract of Cyperus rotundus L. (Cyperaceae) rhizomes showed inhibitory activity against a-glucosidase and a-amylase, two enzymes involve in carbohydrate digestion. Objective: Identification of compounds from C. rotundus rhizomes responsible for the inhibition of a-glucosidase and a-amylase. Materials and methods: Compounds were identified by a phytochemical investigation using combined chromatographic and spectroscopic methods. a-glucosidase and a-amylase inhibitory activities were evaluated by in vitro enzyme inhibition assays.0 ,5,6,7,8-hexahydroxyflavane (1), together with three known stilbene dimers cassigarol E (2), scirpusin A (3) and B (4) were isolated. Compound 2 inhibited both a-glucosidase and a-amylase activities while the flavane 1 only showed effect on a-amylase, and compounds 3 and 4 were active on a-glucosidase. All four compounds showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Discussion: The inhibitory activities against a-amylase and a-glucosidase of the C. rotundus rhizomes were reported for the first time. Stilbene dimers are considered as potent inhibitors of a-glucosidase and promising antihyperglycemic agents. Conclusion: The isolated compounds may contribute to the antidiabetic property of C. rotundus.

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“…Anti-atherosclerotic, reduces serum hyper lipidemia, useful in coronary heart disease [50] Chitraka (Plumbago zeylanica) Prevents platelet adhesion, prolongs bleeding time by altering platelet adhesion and coagulation [51] Musta (Cyperus rotundus) Antiplatelet aggregating activity [52] Katukarohini (Picrorhiza kurroa) Antithrombic, anti-inflammatory [53] Devadaru (Cedrus deodara) Antihyperglycemic [54] Samangaa (Rubia cordifolia) Antithrombic, antioxidant, blood purifier, regulates blood pressure and vaso constriction [55] Shalmali (Salmalia malabarica) Hypoglycemic, antihyperglycemic, analgesic [56] Udeechya (Pavonia odorata) Antidiabetic, hypoglycemic [57] Chandana (Santalum album) Antioxidant, NO scavenging activity, reduces angina pain, anti-inflammatory [58] Anti-hyperglycemic, antihyperlipidemic, cardio protective [59] Dhataki (Woodfordia fruticosa) Anti hyperglycemic, antioxidant [60] Anti-inflammatory, anti-nociceptive [61] Talisa (Abies webbiana) Inhibits platelet aggregation, useful in thrombo-embolic conditions [62] Kakamachi (Solanum nigrum) Antinociceptive, anti-inflammatory, antipyretic [63] Antidiabetic [64] Antioxidant, hypolipidemic [65] Lodhra (Symplocos recemosa) Antioxidant, anti-inflammatory, antidiabetic [66] Padmaka (Prunus puddum) Analgesic, antioxidant, diuretic [67] Gunja (Abrus precatorius) Antidiabetic [68] Antithrombic [69] Antiplatelet, antiviral, antioxidant, anti-inflammatory [65] Madanaphala (Randia dumetorum) Analgesic, anti-inflammatory [70] Antidiabetic, antihyperlipidaemic, anti-hyperglycemic, antioxidant [71] Danti (Baliospermum montanum) Antidiabetic, decreases blood sugar levels and serum cholesterol levels [72] Kutaja (Holarrhena antidysenterica) Antidiabetic, decreases serum cholesterol, triglycerides and increases liver glycogen [73] Chavya (Piper retrofractum) Antihypertensive [59] Murva (Marsdenia tenacissima) Antiobesity [74] Patha (Cissampelos pareira) Antidiabetic [75] Karanja (Pongamia pinnata) Antihyperglycemic [76] Nya...…”

Section: Internal Medicinesmentioning

confidence: 99%

Untitled

Mamidi

2017

IJGP

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Urustambha is a grave condition, in which the patient's thighs become painful, numb and immobile. Urustambha is a disease which is not amenable to panchakarma (five evacuative procedures) treatment. Till date, there is no clear understanding of the concept of Urustambha and its clinical application. This article is aimed to understand the concept of Urustambha and its correlation with relevant modern pathology or disease. Urustambha is a lifestyle disease and it is commonly seen in higher socioeconomic status. Urustambha samprapti resembles with atherogenesis. Diva swapna and raatri jaagarana explained in Urustambha nidaana may indicate obstructive sleep apnea (OSA). Clinical presentation of Urustambha may be unilateral or bilateral or both. Charaka's version of Urustambha indicates vascular pathology like "aortoiliac occlusion" with an underlying "metabolic syndrome (MS)," whereas Sushruta's version of Urustambha indicates inflammatory pathology of spinal cord like "acute transverse myelitis" or "inflammatory myelopathy" or "infectious myelitis." Principles of Urustambha are applicable for the prevention and management of the conditions like atherosclerosis, MS, OSA, aortoiliac occlusion, diabetes mellitus, obesity, cardiovascular pathology, acute myelopathy and other ischemic and inflammatory spinal diseases.

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Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone

Cited by 88 publications

References 43 publications

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

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