Antiplatelet Effect of Losartan and Telmisartan in Patients With Ischemic Stroke

Yamada, Koji; Hirayama, Toshikazu; Hasegawa, Yasuhiro

doi:10.1016/j.jstrokecerebrovasdis.2007.07.003

Cited by 24 publications

(15 citation statements)

References 22 publications

(29 reference statements)

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“…The results of the present study indicate that patients with WBPT ≥ 70.0 s or 50.0 - 70.0 s exhibited a significantly higher risk of urinary albuminuria and high RRI than patients with WBPT ≤ 50.0 s. Although this was a cross-sectional study, we believe that it is possible to evaluate the risk of progression of kidney dysfunction in hypertensive patients by measuring WBPT. Some clinical studies have indicated that medications, such as anti-hypertensive drugs and anti-hyperlipidemic drugs, and smoking cessation improve hemorheology; however, no statistically significant association between these factors and hemorheology was observed in this cross-sectional study [33-35]. We suggest that kidney dysfunction can be prevented by interventions such as medication or lifestyle modification in hypertensive patients to maintain WBPT ≤ 50.0 s.…”

Section: Discussioncontrasting

confidence: 63%

Relationship Between Hemorheology Assessed Using Microchannel Array Flow Analyzer and Kidney Function in Hypertensive Patients

Hatori¹

2017

Cardiol Res

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BackgroundKidney function is known to be closely associated with the pathogenesis of hypertension. In contrast, hemorheology assessed using microchannel array flow analyzer (MC-FAN) has demonstrated the significance of cardiovascular risk factors in recent clinical studies. The present cross-sectional study aimed to clarify the relationship between hemorheology assessed by MC-FAN and kidney function in hypertensive patients from the perspective of primary prevention of cardiovascular events.MethodsIn total, 453 outpatients undergoing treatment for hypertension (176 men and 277 women; mean age ± standard deviation: 65 ± 13 years) with no history of cardiovascular disease were enrolled. Whole blood passage time (WBPT) was measured using MC-FAN as a marker of hemorheology, and the relationships with various clinical parameters including kidney function were examined.ResultsA significant correlation was observed between WBPT and the parameters of kidney function such as estimated glomerular filtration rate (r = -0.14, P < 0.01), urinary albumin excretion (r = 0.40, P < 0.001), and renal resistive index (r = 0.44, P < 0.001). Furthermore, multivariate analysis demonstrated urinary albumin excretion, renal resistive index, skin autofluorescence, derivatives of reactive oxygen metabolites, and hematocrit as independent variables for WBPT as a subordinate factor.ConclusionsThe results of the present study indicate that hemorheology assessed by the MC-FAN is significantly associated with markers of kidney function, such as albuminuria and increased renovascular resistance, in hypertensive patients.

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Section: Discussioncontrasting

confidence: 63%

Relationship Between Hemorheology Assessed Using Microchannel Array Flow Analyzer and Kidney Function in Hypertensive Patients

Hatori¹

2017

Cardiol Res

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“…9 Both telmisartan and losartan have platelet antiaggregatory activity that is not shared by valsartan's, candesartan's, or losartan's major metabolite, EXP3174. [10][11][12][13] Losartan also reduces uric acid, an end-product of purine metabolism linked to the progression of renal disease 14 and increased CV risk 15 and implicated in the development of hypertension in children. 16 It has been hypothesized that these pleiotropic effects of specific ARBs could contribute to the lower incidence of stroke than predicted by BP reduction in outcomes trials of hypertensive patients treated with ARBs compared with treatment with other antihypertensive drugs.…”

Section: Pharmacologic Actions Unique To Specific Arbsmentioning

confidence: 99%

Angiotensin Receptor Blockers: Pharmacology, Efficacy, and Safety

Taylor

Siragy

Nesbitt

2011

The Journal of Clinical Hypertension

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Key Points and Practical Recommendations• The angiotensin receptor blockers are highly effective antihypertensive agents that are also particularly well tolerated.• There are no major differences in efficacy or other clinical characteristics among older drugs in this class, although some of the newer agents may more effectively reduce blood pressure than older agents.• Major randomized clinical trials have demonstrated that angiotensin receptor blockers provide significant outcomes benefits in conditions such as diabetic nephropathy, chronic heart failure or heart failure following myocardial infarction, hypertension with left ventricular hypertrophy and in patients whose histories of previous events or complicated diabetes puts them at high cardiovascular risk.• In treating hypertension, angiotensin receptor blockers can be used as first-line therapy or added at later stages of treatment titration.• These drugs are very effective in combination with thiazide diuretics or calcium channel blockers and there are several single-pill, fixed-dose combinations of angiotensin receptor blockers with hydrochlorothiazide, amlodipine, or aliskiren. These combinations can be given as initial therapy (where appropriate) or later in the course of treatment. Three-drug combinations (angiotensin receptor blocker plus amlodipine plus hydrochlorothiazide and angiotensin receptor blocker plus aliskiren plus hydrochlorothiazide) are also available. J Clin Hypertens (Greenwich). 2011;13:677-686. Ó2011 Wiley Periodicals, Inc.The renin-angiotensin-aldosterone system (RAAS) plays an important role in protecting vertebrates against cardiovascular collapse due to hypotension and volume loss in the event of traumatic injury that involves blood loss. In certain humans, however, inappropriate or exaggerated activity of the RAAS contributes to the development of hypertension and the initiation of a molecular cascade in tissues with consequent injury to critical organs such as the brain, kidneys, heart, and blood vessels. 1-3 As understanding of the pathologic role of the RAAS in hypertensive vascular disease has unfolded during the past century, so has the interest in developing drugs that could interdict specific components of the RAAS. The first of the RAAS-blocking drugs to become commercially available were the aldosterone antagonists in the 1970s, followed by the angiotensin-converting enzyme (ACE) inhibitors in the 1980s and the angiotensin II receptor blockers (ARBs) in the 1990s. Unlike ACE inhibitors that inhibit the conversion of angiotensin I to II, ARBs bind to the angiotensin II AT 1 receptor, thereby inhibiting the cellular actions of angiotension II mediated by the receptor in which the tissue is located. During the past 20 years, studies in the laboratory and clinic have documented that ARBs, either alone or in combination with drugs of other classes, reduce blood pressure (BP) in hypertensive animals and humans; reduce rates of myocardial infarction (MI), stroke, and progression of renal impairment; and positively impact oth...

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“…The results of this study indicate that patients with WBPT ≥ 70.0 s or 50.2 -69.6 s exhibited a significantly higher risk of high RRI than patients with WBPT ≤ 50.0 s. Although this was a crosssectional study, we believe that it is possible to evaluate the risk of progression of high RRI in patients with type 2 diabetes mellitus by measuring WBPT. Some clinical studies have indicated that medications, such as antidiabetic drugs, antihypertensive drugs, and antihyperlipidemic drugs, and smoking cessation, improve hemorheology, even though no statistically significant associations between these factors and WBPT were observed in this cross-sectional study [37][38][39][40]. We suggest that an increase in RRI can be prevented by interventions such as medication or lifestyle modification in patients with type 2 diabetes mellitus to maintain WBPT ≤ 50.0 s. This study has several limitations.…”

Section: Discussionmentioning

confidence: 53%

Clinical Impact of Hemorheology Assessed Using the Microchannel Array Flow Analyzer on Renal Resistive Index in Patients With Type 2 Diabetes Mellitus

Hatori¹

2017

J Endocrinol Metab

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Background: The renal resistive index (RRI) assessed using ultrasonography is reportedly associated with not only kidney function but also cardiovascular disease incidence. In contrast, hemorheology assessed using the microchannel array flow analyzer (MC-FAN) has demonstrated the significance of cardiovascular risk factors in recent clinical studies. This cross-sectional study aimed to clarify the clinical impact of hemorheology assessed using MC-FAN on RRI in patients with type 2 diabetes mellitus from the perspective of primary prevention of cardiovascular events.

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Antiplatelet Effect of Losartan and Telmisartan in Patients With Ischemic Stroke

Cited by 24 publications

References 22 publications

Relationship Between Hemorheology Assessed Using Microchannel Array Flow Analyzer and Kidney Function in Hypertensive Patients

Relationship Between Hemorheology Assessed Using Microchannel Array Flow Analyzer and Kidney Function in Hypertensive Patients

Angiotensin Receptor Blockers: Pharmacology, Efficacy, and Safety

Clinical Impact of Hemorheology Assessed Using the Microchannel Array Flow Analyzer on Renal Resistive Index in Patients With Type 2 Diabetes Mellitus

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