Antiphospholipid syndrome: long-time research on pathogenic mechanisms has finally lead to new therapeutic strategies

Cervera, Ricard; Espinosa, Gerard

doi:10.1517/14728222.2010.530900

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Antiphospholipid syndrome (APS) is defined clinically by the presence of recurrent arterial and venous thrombotic events as well as recurrent pregnancy loss, and serologically by a positive test for antiphospholipid antibodies (i.e. lupus anticoagulant (LA) and anticardiolipin antibodies) [1]. APS is associated with frequent and recurrent thrombosis.…”

Section: Introductionmentioning

confidence: 99%

A case of coronary artery disease with antiphospholipid syndrome that showed repeated stent thrombosis

Mito

Miura

Takada

et al. 2011

Journal of Cardiology Cases

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A 55-year-old man with severe chest pain was hospitalized for acute coronary syndrome. Coronary angiography revealed total occlusion of his left anterior descending coronary artery, which was successfully recanalized by percutaneous coronary intervention (PCI). However, the patient subsequently experienced subacute stent thrombosis, restenosis in the stent, and frequent thrombosis in PCI toward restenosis. Primary antiphospholipid syndrome should be considered as a possible cause of repeated stent thrombosis, and, if salvage by PCI is impossible, salvage by coronary artery bypass graft should be considered.

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Section: Introductionmentioning

confidence: 99%

A case of coronary artery disease with antiphospholipid syndrome that showed repeated stent thrombosis

Mito

Miura

Takada

et al. 2011

Journal of Cardiology Cases

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“…Antiphospholipid syndrome is a systemic autoimmune condition where the presence of antiphospholipid antibodies are thought to predispose to thrombotic events, including arterial and venous thromboses and fetal losses through complex effects on endothelia, platelets and monocytes 23. The clinical presentation can be varied, affecting most organs through effects on their vascular beds 24 Table 8.…”

Section: Discussionmentioning

confidence: 99%

Fitting and flailing: recognition of paediatric antiphospholipid syndrome

Freeman

Patel

Fernández

et al. 2013

Arch Dis Child Educ Pract Ed

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Antiphospholipid syndrome (APS) is a systemic autoimmune condition where the presence of antiphospholipid antibodies is thought to predispose to thrombotic events. It is uncommon in the paediatric population, but current diagnostic criteria are based on adult population studies, making assessment of its true paediatric prevalence difficult. We present two cases of paediatric APS, who presented with primary neurological events, and discuss approaches to diagnosis, interpretation of screening investigations, including antinuclear antibodies (ANA), anti-extractable nuclear antigen (ENA) antibodies and lupus anticoagulant. Possible approaches to the management of paediatric APS are discussed.

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Complement and the antiphospholipid syndrome

Lim

2011

Current Opinion in Hematology

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Activation of complement plays an important role in the pathogenesis of aPL-induced pregnancy morbidity and thrombosis. This understanding has been advanced primarily using mouse models of APS and clinical studies in patients with APS are needed. Although there is currently no specific complement-targeted therapy approved for APS, developing and evaluating complement-targeted therapies in patients with APS are warranted. Complement inhibition may provide a novel upstream treatment option for patients with APS compared with the current standard treatment of anticoagulation.

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Antiphospholipid syndrome: long-time research on pathogenic mechanisms has finally lead to new therapeutic strategies

Cited by 5 publications

References 20 publications

A case of coronary artery disease with antiphospholipid syndrome that showed repeated stent thrombosis

A case of coronary artery disease with antiphospholipid syndrome that showed repeated stent thrombosis

Fitting and flailing: recognition of paediatric antiphospholipid syndrome

Complement and the antiphospholipid syndrome

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