Antiphospholipid antibodies in patients with upper-extremity deep vein thrombosis

Abstract

The levels of antibodies to cardiolipin and β2-glycoprotein I and polymorphic variants G1691A of Factor V (factor V Leiden, FVL) and G20210A of prothrombin gene (G20210A) were studied in 16 patients with upper-extremity deep vein thrombosis (UEDVT). Most of patients with this syndrome have elevated values of these antibodies. Two of these patients are heterozygous carriers for G20210A and 1 – for FVL. Three patients with UEDVT and systemic lupus erythematosus (SLE) are positive for ANA and two others (one of them with Raynaud syndrome) have border line titre 1: 80 for ANA. All 3 patients with SLE are women and the interval between the development of the UEDVT and the onset of SLE was 1-4 years. We would like to suggest that: 1) UEDVT could be the first clinical symptom of Antiphospholipid syndrome, and 2) UEDVT may be the first clinical manifestation of SLE preceding the development of the systemic autoimmune disease by several years.

Paget–Schroetter syndrome: An unfamiliar cause of upper-limb deep venous thrombosis

“…[ 3 5 ] Some authors also suggest the role of thrombophilia state in the pathogenesis of PSS, but this correlation is not conclusive. [ 6 ] Clinically, ULDVT due to PSS is always symptomatic as compared to secondary ULDVT. [ 5 ] In 80%−85% of cases, patients present within 24 h after vigorous upper-limb activity, but this correlation to activity is not always found, and in about 15%−20% of patients, no history of inciting event is present.…”

“…This will help to predict postoperative complications and recurrence rates and determine the need for long-term anticoagulation. [ 5 6 ] In the past, PSS was managed with limb elevation and anticoagulation alone, but now, most of the researchers recommend aggressive and invasive treatment strategy. These consist of local catheter-directed thrombolysis with newer fibrinolytic such as alteplase and reteplase for 24−48 h and thoracic outlet decompression by first rib resection depending on the duration of symptoms.…”

Massive thrombosis in an infant with suspected nephrocalcinosis: case report and literature review

“…In patients with CKD, post-thrombotic occlusion of IVC or iliac veins may be of great difficulty, when placing vascular catheters for hemodialysis or kidney transplantation [ 10 ]. IVC obstruction poses a risk of impaired blood outflow from the lower body and distant complications, including post-thrombotic syndrome (erythema, edema, varicose veins, distal vein thrombosis) [ 9 , 21 , 27 ]. There is no doubt that children who underwent a perinatal thrombosis involving IVC and renal veins require regular follow-up by a nephrologist, with an assessment of renal shape and size, renal function, microalbuminuria, and blood pressure.…”

Influence of antiphospholipid antibody positivity on glomerular filtration rate markers in a group of systemic sclerosis patients – a 24-month observation

“…The most probable mechanism is endothelial injury induced by angiogenetic and angiostatic factors, such as endothelin 1, vascular endothelial growth factor, thrombomodulin, which leads to vascular lesions with generalized microangiopathy and systemic fibrosis [ 20 ]. Moreover, aPL, such as acl and a-β2GPI antibodies, have been implicated in various adverse events, including arterial and venous microthromboembolism, endothelial injury and APS nephropathy [ 21 ]. The findings of our previous study indicate that the presence of aPL may deteriorate renal function in SSc patients.…”