Antipeptide monoclonal antibodies inhibit the binding of rabies virus glycoprotein and alpha-bungarotoxin to the nicotinic acetylcholine receptor

Novel Form of Fibronectin from Zebrafish Mediates Infectious Hematopoietic Necrosis Virus Infection

“…In addition to membrane phospholipids, several studies have provided evidence for the involvement of cellular proteins in mediating rhabdovirus attachment (3,19,29,30). One of the proteins that has been implicated in virus infection is the extracellular matrix protein fibronectin.…”

1H‐ and natural abundance 15N‐nmr studies of a derivative of a rabies glycoprotein fragment

“…This hypothesis was also supported by the observation that monoclonal antibodies, raised against the 190-203 fragment of RVG, inhibited the binding of RVG and a-bungarotoxin to the nicotinic AChR. 4 That the latter antibodies could not recognize the linear peptide was ascribed to the presence, in solution, of a conformational equilibrium where the bioactive reverse turn centered at the NSRG fragment is scarcely present. The potenBiopolyrners.…”

Pathogenesis

“…It was evident from these studies that the distribution of viral antigen detected by fluorescent antibody staining at sites in neuromuscular junctions corresponded to the distribution of nAChRs. Monoclonal antibodies raised against a peptide containing residues 190-203 of the rabies virus glycoprotein also inhibited binding of the rabies virus glycoprotein and α-bungarotoxin to the AChR (Bracci et al, 1988). Pretreatment of myotubes with either the irreversible binding nicotinic cholinergic antagonist α-bungarotoxin or the reversible binding d-tubocurarine reduced the number of myotubes that became infected with rabies virus.…”