“…15 In 2008, Muhammad and co-workers reported antimalarial activity against D6 (chloroquine-sensitive, IC 50 = 4.2 lg/mL) and W2 (chloroquine-resistant, IC 50 = 3.5 lg/mL) strains of P. falciparum for ferruginol (1). 10 Recently, an additional report confirmed significant antimalarial activity against K1 strain (chloroquine-resistant, IC 50 = 0.9 lM), showing moderate selectivity index (SI = 15.6 (in L6 cells)). 16 To further explore the potential of ferruginol (1) as antimalarial candidate, and in continuation of our research programs to discover bioactive terpenoids and new scaffolds as potential antimalarial agents, 17,18 we developed a focused compound library based on (+)-ferruginol (1) using a short, and efficient synthetic strategy from commercially available (+)-dehydroabietylamine (DHAA) (Scheme 1).…”