Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of LPS-induced chronic enteritis

Suchecka, Dominika; Harasym, Joanna; Wilczak, Jacek; Gajewska, Małgorzata; Oczkowski, Michał; Gudej, Sylwia; Błaszczyk, Katarzyna; Kamola, Dariusz; Filip, Rafał; Gromadzka-Ostrowska, Joanna

doi:10.1016/j.jff.2014.12.019

Cited by 50 publications

(44 citation statements)

References 67 publications

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“…In the second trial, some responses were highlighted by the injection of LPS, because this is an agent that prompts the release of reactive oxygen species and is the causal agent of systemic inflammatory responses that promote a number of unfavorable effects such as liberation of countless endogenous inflammatory mediators (Suchecka et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…This indicates that the effects of LPS are observed earlier in the course of immune reaction. The LPS is known to stimulate the production of proteins such as lysozyme, proteins of the complement system, and cells such as T and B lymphocytes and macrophages, resulting directly in increasing innate defense parameters and indirectly in specific defense parameters (Swain et al 2008;Suchecka et al 2015).…”

Section: Discussionmentioning

confidence: 99%

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Dietary carbohydrates and protein of yeast modulate the early stages of innate immune response in tilapia (Oreochromis niloticus) primarily after LPS inoculation

Gonçalves

Sousa

et al. 2016

Aquacult Int

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The administration of yeast-derived immunostimulants leads to improvement of the immune system and growth performance preventing the antibiotics misuses. The objective of this study was to evaluate the effects of dietary Actigen Ò [0, 0.04, 0.06 and 0.08 % of Actigen (ACT)], on the immunological and physiological responses and growth performance of tilapia after lipopolysaccharide (LPS) inoculation. The experiment was conducted in two trials. In the first trial, the ACT was offered for 30 and 60 days; in the second trial, the ACT was offered for 60 days, and then fish were challenged by intraperitoneal injection with LPS and sampled at 5 and 12 days after inoculation. After the first trial, immunological, hematological and biochemical parameters, intestinal morphology and the growth performance were assessed, whereas in the second trial, immunological, hematological and biochemical parameters were assessed. Supplementation of diets with ACT showed a significant effect mainly after 60 days of feeding, with increased lysozyme, globulin, HTC, MCV, erythroblasts, leukocytes, lymphocytes and monocytes. A general decrease in cells and globulin occurred at 5 days after the LPS challenge, with partial recovery at 12 days after the challenge. In addition, the study demonstrated that the use of ACT, an extract derived from yeast cell walls and containing

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary carbohydrates and protein of yeast modulate the early stages of innate immune response in tilapia (Oreochromis niloticus) primarily after LPS inoculation

Gonçalves

Sousa

et al. 2016

Aquacult Int

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show abstract

“…In another study, rats with chronic enteritis induced by LPS were supplemented with beta-glucans from oat (low and high molecular weight fractions). The results showed that supplementation with both fractions significantly decreased leucocytes counting: Lymphocytes T and B, granulocytes and lymphocytes Tc (Suchecka et al, 2015).…”

Section: Introductionmentioning

confidence: 94%

Promising Effects of Beta-Glucans on Metabolism and on the Immune Responses: Review Article

Silva¹,

Moura²,

Oliveira³

et al. 2017

American Journal of Immunology

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A public health issue, Diabetes mellitus, affects millions of people around the globe. Ingestion of foods with a low glycemic indexfiber-rich meals-such as beta-glucans, is increasing as an important alternative for diabetes control. These compounds act reducing parameters such as blood glucose, cholesterol and triglycerides, by decreasing the absorption of glucose and lipids by enterocytes and eventually promote weight loss. Beta-glucans are also described as immunomodulatory agents by stimulating phagocytosis and the production of pro-inflammatory cytokines, increasing host resistance to viral, bacterial, fungal and parasitic infections; or production of anti-inflammatory cytokinesto return homeostasis after an immune response. Besides, some studies are also evidencing anti-tumoral activity. Beta-glucans main effect depends on their origin-yeast, plants or bacteria. Reports of collateral effects and/or toxicity associated with the use of beta-glucans are rare, which contribute to consider this compound for inclusion in a range of therapies. This review aims to evaluate the most different effects of beta-glucans in metabolic and immune systems, discussing its advantages and limitations.

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“…Measuring the antioxidant activity of phenolic extracts from rye whole grain, bran and flour has distinguished rye bran as a source of alimentary phenolic antioxidants, which may potentially bring about positive aftereffects for human health (Andreasen et al, 2001). Consumption of oat bran with an increased level of avenanthramides has been shown to decrease damage in the aorta and produce an obviously beneficial effect upon cardiovascular disease prevention (Thomas et al, 2018). There are publications describing experimental testing of hypotensive and hypoglycemic properties of the bran produced from rice, wheat, oat, barley, sorghum, millet, rye and maze grain.…”

Section: The Role Of Antioxidants In Human Health Preservationmentioning

confidence: 99%

Biological role and health benefits of antioxidant compounds in cereals

Polonskiy

Loskutov

Сумина

2020

BioComm

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Substances inhibiting or preventing oxidative damage in the target molecule are called antioxidants. It has been shown that antioxidants are substances that contribute to the prevention of a number of serious human diseases, and antioxidant activity is one of the important parameters for the quality of food products and ingredients. Phenolic compounds are of greatest importance for this review. It is now established that whole grain cereals contain a large number of bound polyphenols. It is known that cereals have high nutritional value, contain unsaturated fatty acids, basic mineral elements, proteins and β-glucans, and are also characterized by the presence of various chemical substances with antioxidant properties. In recent years, work has begun in some Western countries to study the content of antioxidants in various grains. In Russia, only a small amount of work has been devoted to the study of these important chemical compounds in grain crops. It should be noted that, although these species are considered to be one of the main components of human nutrition, research in the field of determining their antioxidant activity has not been sufficiently carried out. In order to attract the attention of plant growers, plant breeders, plant physiologists, geneticists and biotechnologists, we offer a review of current literature.

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Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of LPS-induced chronic enteritis

Cited by 50 publications

References 67 publications

Dietary carbohydrates and protein of yeast modulate the early stages of innate immune response in tilapia (Oreochromis niloticus) primarily after LPS inoculation

Dietary carbohydrates and protein of yeast modulate the early stages of innate immune response in tilapia (Oreochromis niloticus) primarily after LPS inoculation

Promising Effects of Beta-Glucans on Metabolism and on the Immune Responses: Review Article

Biological role and health benefits of antioxidant compounds in cereals

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