Antioxidants for male subfertility

Showell, Marian; Brown, Julie; Yazdani, Anusch; Stankiewicz, M.; Hart, Roger

doi:10.1002/14651858.cd007411.pub2

Cited by 296 publications

(124 citation statements)

References 59 publications

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“…There are varied reports [116][117][118] on the efficiency of various antioxidant therapy in infertile men. Recent meta analysis [119,120] of these studies suggest that antioxidant therapy is beneficial and improves various indices of male fertility. However antioxidants should only be administered in cases with increased free radical levels as majority of enzymatic reactions in our body functions under redox conditions.…”

Section: Resultsmentioning

confidence: 99%

Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility

Shamsi

Imam

Dada

2011

J Assist Reprod Genet

135

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Sperm is not a simple carrier of paternal genetic information but its role extends clearly beyond fertilization. Integrity of sperm genome is an essential pre-requisite for birth of healthy offspring and evaluation of sperm should entail DNA integrity analysis. DNA integrity analysis is a better diagnostic and prognostic marker of sperm reproductive potential. Conventional semen analysis emphasizes on sperm concentration, viability, motility and morphology and has been proven to be a poor indicator of reproductive potential and pregnancy outcome. To overcome the drawbacks associated with conventional semen analysis more useful fertility tests and molecular biomarkers have been explored. Among the different tests which have evolved for assessing the sperm reproductive potential, tests for sperm DNA quality are most promising. Sperm DNA damage has been closely associated with numerous indicators of reproductive health including fertilization, embryo quality, implantation, spontaneous abortion, congenital malformations and childhood diseases. It therefore has great potential as a prognostic test for both in vitro and in vivo conception. This review presents an updated account of tests that have better diagnostic and prognostic implications in the evaluation of sperm DNA damage. The basic principles, outline of methodology, advantage, disadvantage, clinical significance of each technique and implications of these tests have been discussed. The logistics of each test with respect to available resources and equipment in an andrology laboratory, the feasibility of performing these tests in routine diagnostic workup of infertile men and the opportunities and challenges provided by DNA testing in male fertility determination are also presented.

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Section: Resultsmentioning

confidence: 99%

Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility

Shamsi

Imam

Dada

2011

J Assist Reprod Genet

135

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“…A systematic review by Cochrane [38] was published to evaluate the effect of oral supplementation with different antioxidants for male partners of couples undergoing assisted reproduction techniques. Compared with the present study, Showell et al [38], which included only two trials, obtained comparable results and concluded that although the seminal parameters appeared to improve after supplementation with CoQ10, there was no change in the pregnancy rate.…”

Section: Discussionmentioning

confidence: 99%

“…The damaging effects of oxidative stress on sperm are considered to be responsible for 30 % to 80 % of male subfertility cases [38]. It is well known that spermatozoa are susceptible to oxidative damage and reactive oxygen species (ROS), and numerous studies support the hypothesis that ROS are responsible for sperm dysfunction and male infertility [3,34].…”

Section: Introductionmentioning

confidence: 99%

“…Recently there has been growing interest in identifying reversible causes of male infertility, and numerous studies have been performed to investigate whether supplementing infertile men with antioxidants can improve seminal parameters [38].…”

Section: Introductionmentioning

confidence: 99%

“…Among the various antioxidants tested, CoQ10 (as a component of the mitochondrial respiratory chain) appears to play an important role in energy metabolism, as well as functioning as a liposoluble chain-breaking antioxidant for cell membranes and lipoproteins [38].…”

Section: Introductionmentioning

confidence: 99%

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Coenzyme Q10 and male infertility: a meta-analysis

Lafuente

González-Comadran

Solà

et al. 2013

J Assist Reprod Genet

138

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Objective To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility. Materials and methods Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group. Results None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I 2 =17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I 2 =58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I 2 =0 %)Conclusion There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.

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