Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration

Abstract

Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.

Effects of lutein supplementation in age-related macular degeneration

“…In this way, our results that lutein supplementation can increase MPOD and visual acuity are in agreement with previous studies and a meta-analysis that included fewer studies than ours [52]. On the other hand, one meta-analysis suggested little to no benefit of lutein against AMD progression [53]. The results of that analysis may be less reliable because among the 19 studies included, only 6 examined lutein in AMD, and most data came from a single study (AREDS2).…”

Effects of lutein supplementation in age-related macular degeneration

“…In this way, our results that lutein supplementation can increase MPOD and visual acuity are in agreement with previous studies and a meta-analysis that included fewer studies than ours [52]. On the other hand, one meta-analysis suggested little to no benefit of lutein against AMD progression [53]. The results of that analysis may be less reliable because among the 19 studies included, only 6 examined lutein in AMD, and most data came from a single study (AREDS2).…”

Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin

“…The results of this study demonstrating the effectiveness of lutein, zeaxanthin, αtocopherol, and ascorbate in scavenging retinoid cation radicals are consistent with the results of a large multicentre randomized placebo-controlled clinical trial Age-Related Eye Disease Study 2 (AREDS2) showing that a daily supplementation with zinc, vitamins C and E, lutein, and zeaxanthin slows down the progression of AMD, particularly in persons with low dietary intake of these antioxidants [31][32][33]. AREDS2 also demonstrated that including lutein and zeaxanthin in the antioxidant mixture brings about a greater benefit than having no carotenoids or β-carotene.…”

Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population

“…Finally, walnuts are also rich in Υ-tocopherol—a form of vitamin E—as we have explained before, a powerful antioxidant with anti-inflammatory properties, with protective and preventive action in macular diseases, such as AMD [139]. Non-sodium minerals such as potassium, calcium and magnesium, shared by all nuts, and especially in walnuts, also have a protective effect on cardio-metabolic risk, as confirmed by recent evidence [138,139].…”

Effects of lutein supplementation in age-related macular degeneration

“…In this way, our results that lutein supplementation can increase MPOD and visual acuity are in agreement with previous studies and a meta-analysis that included fewer studies than ours [52]. On the other hand, one meta-analysis suggested little to no benefit of lutein against AMD progression [53]. The results of that analysis may be less reliable because among the 19 studies included, only 6 examined lutein in AMD, and most data came from a single study (AREDS2).…”

Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin

“…The results of this study demonstrating the effectiveness of lutein, zeaxanthin, αtocopherol, and ascorbate in scavenging retinoid cation radicals are consistent with the results of a large multicentre randomized placebo-controlled clinical trial Age-Related Eye Disease Study 2 (AREDS2) showing that a daily supplementation with zinc, vitamins C and E, lutein, and zeaxanthin slows down the progression of AMD, particularly in persons with low dietary intake of these antioxidants [31][32][33]. AREDS2 also demonstrated that including lutein and zeaxanthin in the antioxidant mixture brings about a greater benefit than having no carotenoids or β-carotene.…”

Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population

“…Finally, walnuts are also rich in Υ-tocopherol—a form of vitamin E—as we have explained before, a powerful antioxidant with anti-inflammatory properties, with protective and preventive action in macular diseases, such as AMD [139]. Non-sodium minerals such as potassium, calcium and magnesium, shared by all nuts, and especially in walnuts, also have a protective effect on cardio-metabolic risk, as confirmed by recent evidence [138,139].…”

Effects of lutein supplementation in age-related macular degeneration

“…In this way, our results that lutein supplementation can increase MPOD and visual acuity are in agreement with previous studies and a meta-analysis that included fewer studies than ours [52]. On the other hand, one meta-analysis suggested little to no benefit of lutein against AMD progression [53]. The results of that analysis may be less reliable because among the 19 studies included, only 6 examined lutein in AMD, and most data came from a single study (AREDS2).…”

Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin

“…The results of this study demonstrating the effectiveness of lutein, zeaxanthin, αtocopherol, and ascorbate in scavenging retinoid cation radicals are consistent with the results of a large multicentre randomized placebo-controlled clinical trial Age-Related Eye Disease Study 2 (AREDS2) showing that a daily supplementation with zinc, vitamins C and E, lutein, and zeaxanthin slows down the progression of AMD, particularly in persons with low dietary intake of these antioxidants [31][32][33]. AREDS2 also demonstrated that including lutein and zeaxanthin in the antioxidant mixture brings about a greater benefit than having no carotenoids or β-carotene.…”

Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population

“…Finally, walnuts are also rich in Υ-tocopherol—a form of vitamin E—as we have explained before, a powerful antioxidant with anti-inflammatory properties, with protective and preventive action in macular diseases, such as AMD [139]. Non-sodium minerals such as potassium, calcium and magnesium, shared by all nuts, and especially in walnuts, also have a protective effect on cardio-metabolic risk, as confirmed by recent evidence [138,139].…”