Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases

Abstract

Background:Treatment of periodontal diseases by nonsurgical debridement has been considered as a gold standard procedure. Various other treatment modalities have been tried and tested to treat periodontal diseases. The aim of this study was to investigate the effect of antioxidant therapy on the progression of periodontal disease as monotherapy and/or as an adjunct to nonsurgical debridement.Materials and Methods:70 subjects were divided into three groups, i.e. clinically healthy, gingivitis and periodontitis group on the basis of Community Periodontal Index of Treatment Needs score. Gingivitis and periodontitis groups were further subdivided into three subgroups. At the baseline, periodontal attachment loss was recorded and scaling and root planing was performed in two subgroups. 6 mg antioxidant was administered in three divided doses for 2 weeks. Saliva samples were collected at baseline, 15th day, 30th day and 45th day for evaluation of uric acid levels.Results:Uric acid levels were significantly low in patients with more periodontal attachment loss as compared to clinically healthy and gingivitis groups. As the treatment was initiated, significant increase in uric acid levels was observed.Conclusion:Rise in salivary antioxidant levels was observed on the administration of antioxidant therapy. Hence, antioxidant therapy can be used as an adjunct to the nonsurgical periodontal therapy.

Impact of Consumption of Chicory Leaf Extract in Adjunct with Non-surgical Periodontal Therapy on Serum Antioxidant and Lipid Status in Patients with Periodontal Disease: Preliminary Study

“…Cristina Mourão et al (2015) reported that the level of LDL, glucose and uric acid increases in chronic periodontitis (40). Aditi Mathur and co-workers observed that patients suffering from periodontal disease have high level of uric acid, indicating the elevation of antioxidant function (41); our results confirm the previous findings of elevation in uric acid in periodontal disease. However, there is no evidence to report the role of dietary intervention on the serum levels of uric acid.…”

Antibiotics in Periodontal Therapy: To Use or Not To Use?

“…Antioxidants play crucial role in maintaining integrity of epithelium, cell signaling and host defense mechanism [24]. Despite of limited data about use of antioxidants as adjunctive periodontal therapy; however, available studies suggest promising results to use these agents for the prevention and treatment of periodontal diseases [25,26].…”

Reactive Oxygen Species (ROS): A Review

“…24 A variety of biological processes, eg., antimicrobial defense, inflammation, carcinogenesis, radiation damage, photobiological effects, and aging, involve reactive oxygen species. 25 Reactive oxygen species (ROS) play crucial roles in normal physiological processes including response to growth factors, the immune response, and apoptotic elimination of damaged cells but are also highly toxic and destructive when generated during the respiratory burst as it represents an important pathogenic mechanism for tissue damage and diseases associated with phagocytic insiltration. 26 Excessive production of ROS resulting in oxidative stress has been implicated in the pathogenesis of many human diseases including periodontitis.…”