Antioxidant-Rich Dietary Intervention Improves Cardiometabolic Profiles and Arterial Stiffness in Elderly Koreans with Metabolic Syndrome

Abstract

Purpose Oxidative stress plays an important role in the pathogenesis of chronic metabolic diseases. This study investigated the effect of the antioxidant-rich dietary intervention on oxidative stress, metabolic parameters, and arterial stiffness in elderly Koreans with metabolic syndrome (MetS). Materials and Methods Thirty-one subjects with MetS were enrolled and randomly divided into dietary intervention group and control group. Subjects in the intervention group received three meal boxes prepared with antioxidant-rich ingredients every day for 4 weeks, and subjects in the control group maintained their usual diets. Anthropometric and various biochemical parameters related to oxidative stress, inflammation, and MetS were assessed. Brachial-ankle pulse wave velocity (baPWV) and fat measurement using computed tomography were also conducted before and after 4 weeks. Results There were significant differences in waist circumference, visceral to subcutaneous fat ratio, lipid peroxidation, oxidized low density lipoprotein (oxLDL), systolic and diastolic blood pressure, lipid parameters, advanced glycation end products, and baPWV between before and after the study in the experimental group (all p <0.05). Significant inter-group differences were observed between the experimental and control group in terms of the differences in body mass index, waist circumference, oxygen radical absorbance capacity, protein carboxylation, lipid peroxidation, oxLDL, blood pressure, lipid parameters, and baPWV between before and after the study (all p <0.05). Conclusion Antioxidant-rich dietary intervention for a 4-week period ameliorated the state of oxidative stress and improved the components of MetS including central obesity, dyslipidemia, hypertension, and arterial stiffness in elderly Koreans with MetS.

Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation

“…We performed logistic regression analyses in the entire study population, as well as in each of the two hs-CRP groups. Given that chronic systemic inflammation is strongly related to cardiometabolic health, 23 24 we a priori selected the following covariates: demographics (age, sex, years of education), history of cardiometabolic disease (hypertension, diabetes mellitus, and angina or myocardial infarction), cardiometabolic risk behaviors (smoking status [never, former, or current smoker], alcohol consumption [currently drinking or not], and engagement in vigorous exercise [yes or no]), and cardiometabolic risk biomarkers (systolic blood pressure, diastolic blood pressure, fasting blood glucose level, and total cholesterol level). Survey year and intracranial volume were also adjusted for in line with our previous study.…”

Inflammation and Oxidative Stress in Frailty and Metabolic Syndromes—Two Sides of the Same Coin

“…In the context of treatment of the metabolic syndrome, a special role is played by the influence on healthy nutrition, physical activity and sleep hygiene. In elderly Koreans with metabolic syndrome, antioxidant-rich dietary intervention for four weeks resulted in a decrease in oxidized low-density lipoproteins and lipid peroxidation levels (which are oxidative stress markers) and ameliorated the central obesity, dyslipidemia, hypertension, and arterial stiffness [71]. Mendoza-Núñez et al studied the effects of tai chi exercise on antioxidant markers in metabolic syndrome, sedentary older patients.…”