Antioxidant protecting effects of vitamin B6 at reducing hemodynamic toxicity of gentamicin in rat model of nephrotoxicity

Pahlavanzadeh, Farahnaz; Bidadkosh, Arash; Derakhshanfar, Amin; Rastegar, A.; Rushanzamir, Majid

doi:10.1007/s00580-012-1458-x

Cited by 6 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 Vitamin B6's specificity in restoring glomerular hemodynamics and the disruption of renal vasodilator metabolism appears to be linked to the accelerated formation of renal PLP, which counteracts nephrotoxicity's oxidative responses, and this is most likely the primary method by which this vitamin exerts its nephron-protective effects. 15…”

Section: Research Articlementioning

confidence: 99%

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Zakri¹,

Al-Shawi²

2022

IJDDT

View full text Add to dashboard Cite

Nephrotoxicity is defined as rapid deterioration in kidney functions that arises from direct exposure to a drug or its metabolite. Methotrexate is an anti-metabolite used in low doses for autoimmune and inflammatory disorders and high doses for different malignancies. Pyridoxine is the usual form of vitamin B6 included in pharmaceutical products. This study is designed to examine the effect of pyridoxine in two different doses, each co-administered with methotrexate at 20 mg/kg made renal toxicity in rats through the involvement of Nrf2/HO-1 molecular mechanism in this respect. The animals used in this research were allocated to four distinct groups (each group with 10 rats) of both sexes; as control, MTX, pyridoxine 33 mg/kg and MTX, Pyridoxine 100 mg/kg, and MTX. Serum creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and NrF2/HO-1 signaling pathway were determined. Administration of Pyridoxine (33 mg/kg intraperitoneally) in combination with MTX showed no significant differences (p >0.05) as compared to the MTX group. At the same time, administration of pyridoxine (100 mg/kg intraperitoneally) in combination with methotrexate showed a significant reduction in serum activities of both neutrophil gelatinase associated lipocalin (NGAL) and creatinine (p is less than 0.05) and significant upregulation in Nrf2/HO-1 signaling pathway each compared to corresponding levels in MTX-only group. In conclusion, this study demonstrated that when pyridoxine (100 mg/kg IP) was administered in combination with methotrexate, the renal toxicity was reduced as a result.

show abstract

Section: Research Articlementioning

confidence: 99%

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Zakri¹,

Al-Shawi²

2022

IJDDT

View full text Add to dashboard Cite

show abstract

“…Eventually, both vitamin B6 and vitamin B12 have significant role in synthetic pathway of myelin sheath and maintenance of its integrity [13,18]. Moreover, these vitamins also got antioxidant activity to some extent [19,20]. Five distinct case reports has been published between 2004 to 2016 figured out the potential efficacy of pyridoxine and pyridostigmine in treating VIPN with cranial involvement [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Vitamin B6 and Vitamin B12 against Vincristine- Induced Peripheral Neuropathy: A Randomized, Double- Blind, Placebo Controlled, Multicenter Trial

Jeenia¹,

Sojib²

2022

JPPR

View full text Add to dashboard Cite

Background: Vincristine leads to development of debilitating neuropathy in 40-45% patients with resultant compromised efficacy of chemotherapy, suboptimal treatment and worse prognostic outcome. Vitamin B6 and vitamin B12 improves non- oncological neuropathies. Therefore, this study investigated vitamin B6 and vitamin B12 to prevent vincristine- induced peripheral neuropathy (VIPN) by reducing incidence, absolute risk, relative risk, severity as well as delaying the onset. Methods: Patients with ALL undergoing induction phase were randomly assigned into intervention or placebo arm in a double- blind manner. Vitamin B6 (25 mg Pyridoxine) two tablets were given three times daily for 5 weeks. Vitamin B12 (500 μg/ml Methyl cobalamin) was administered intravenously on day 1, 3 and 5 of every week for 5 weeks during induction period. Placebo arm received oral and intravenous placebo for same duration. Patients were evaluated on the outset of every week by FACT/GOG-NTX questionnaire. Severity was assessed per NCI-CTCAE grading scale. Results: 102 patients were enrolled. Among them 81 completed the study, where 42 received vitamin B6 and B12 and 39 received placebo. There was significant difference in incidence of neuropathy between arms (26.19% intervention arm, 56.41% placebo; P-0.01). Relative risk of neuropathy was significantly (RR-0.46) lower in intervention arm. Besides, absolute risk reduction (ARR) was 30% and relative risk reduction (RRR) was 54%. NNT was 3.33. Significant trend was observed in difference of severity of VIPN between groups (P-0.03). No significant difference observed in between arms for time to onset of neuropathy. Conclusion: Vitamin B6 and vitamin B12 significantly reduced the incidence, relative risk and severity of VIPN. NNT was encouraging too. Henceforth, the status of vitamin B6 and vitamin B12 as neuroprotective agent against VIPN can be recommended as a promising one.

show abstract

“…Eventually, both vitamin B 6 and vitamin B 12 have significant role in synthetic pathway of myelin sheath and maintenance of its integrity [13,18]. Moreover, these vitamins also got antioxidant activity to some extent [19,20]. Five distinct case reports has been published between 2004 to 2016 figured out the potential efficacy of pyridoxine and pyridostigmine in treating VIPN with cranial involvement [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of vitamin B₆ and vitamin B₁₂ against vincristine- induced peripheral neuropathy: A randomized, double- blind, placebo controlled, multicenter trial

Jeenia

Rahman

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Vincristine leads to development of debilitating neuropathy in 40-45% patients with resultant compromised efficacy of chemotherapy, suboptimal treatment and worse prognostic outcome. Vitamin B6 and vitamin B12 improves non- oncological neuropathies. Therefore, this study investigated vitamin B6 and vitamin B12 to prevent vincristine- induced peripheral neuropathy (VIPN) by reducing incidence, absolute risk, relative risk, severity as well as delaying the onset. Methods: Patients with ALL undergoing induction phase were randomly assigned into intervention or placebo arm in a double- blind manner. Vitamin B6 (25 mg Pyridoxine) two tablets were given three times daily for 5 weeks. Vitamin B12 (500 μg/ml Methylcobalamin) was administered intravenously on day 1, 3 and 5 of every week for 5 weeks during induction period. Placebo arm received oral and intravenous placebo for same duration. Patients were evaluated on the outset of every week by FACT/GOG-NTX questionnaire. Severity was assessed per NCI-CTCAE grading scale. Results: 102 patients were enrolled. Among them 81 completed the study, where 42 received vitamin B6 and B12 and 39 received placebo. There was significant difference in incidence of neuropathy between arms (26.19% intervention arm, 56.41% placebo; P-0.01). Relative risk of neuropathy was significantly (RR-0.46) lower in intervention arm. Besides, absolute risk reduction (ARR) was 30% and relative risk reduction (RRR) was 54%. NNT was 3.33. Significant trend was observed in difference of severity of VIPN between groups (P-0.03). No significant difference observed in between arms for time to onset of neuropathy. Conclusion: Vitamin B6 and vitamin B12 significantly reduced the incidence, relative risk and severity of VIPN. NNT was encouraging too. Henceforth, the status of vitamin B6 and vitamin B12 as neuroprotective agent against VIPN can be recommended as a promising one.

show abstract

Antioxidant protecting effects of vitamin B6 at reducing hemodynamic toxicity of gentamicin in rat model of nephrotoxicity

Cited by 6 publications

References 28 publications

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Neuroprotective Effect of Vitamin B6 and Vitamin B12 against Vincristine- Induced Peripheral Neuropathy: A Randomized, Double- Blind, Placebo Controlled, Multicenter Trial

Neuroprotective effect of vitamin B₆ and vitamin B₁₂ against vincristine- induced peripheral neuropathy: A randomized, double- blind, placebo controlled, multicenter trial

Contact Info

Product

Resources

About

Antioxidant protecting effects of vitamin B6 at reducing hemodynamic toxicity of gentamicin in rat model of nephrotoxicity

Cited by 6 publications

References 28 publications

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Effects of Co-administration of Pyridoxine in Two Different Doses with Methotrexate-induced Nephrotoxicity in Rats

Neuroprotective Effect of Vitamin B6 and Vitamin B12 against Vincristine- Induced Peripheral Neuropathy: A Randomized, Double- Blind, Placebo Controlled, Multicenter Trial

Neuroprotective effect of vitamin B6 and vitamin B12 against vincristine- induced peripheral neuropathy: A randomized, double- blind, placebo controlled, multicenter trial

Contact Info

Product

Resources

About

Neuroprotective effect of vitamin B₆ and vitamin B₁₂ against vincristine- induced peripheral neuropathy: A randomized, double- blind, placebo controlled, multicenter trial