Antioxidant properties of Indian medicinal plants

Jadhav, Hemant R.; Bhutani, K. K.

doi:10.1002/ptr.1063

Cited by 52 publications

(35 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, this could be associated with a down regulation in LDL receptors by the cholesterol in the diet, which could also explain the elevation of serum LDL cholesterol levels or non-HDL levels either by changing hepatic LDL receptor activity, the LDL production rate or both (Jadhav and Bhutani, 2002) In the present study rats fed with AD showed significant increase in TC, TG and non-HDL, TC: HDL and AI values (Table 2) confirming that cholesterol feeding induced hypercholesteremia experimentally. When compared to AD treated group, treatment of experimentally induced hyperlipidemic rats with MECF and AECF at the dose of 400 mg/kg showed highly significant decrease of non-HDL, TC: HDL and AI (p < 0.001) TC showed significant of (p < 0.05) whereas TG does not showed significant, with significant increase in HDL (p < 0.001) than the lower dose of 200 mg/kg.…”

Section: Discussionsupporting

confidence: 75%

Screening of Different Leaf Extracts of Cassia fistula Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

Sutar¹,

Dass²,

Einstein

2014

ILNS

View full text Add to dashboard Cite

The present investigation was carried out to evaluate the hypolipidemic activity of methanolic and aqueous leaf extracts of Cassia fistula (CF) Linn (Family: Fabaceae) on atherogenic diet (2% cholesterol, 1% Choline Chloride and 2% Lard) induced Male Sprauge-Dawley rats for the period of 21 days. The rats receiving the treatment with leaf methanol and aqueous extract of CF showed significant (P < 0.001) reduction in total cholesterol (TC), triglycerides (TG), High density lipoprotein (HDL), lipid peroxidation (LPO) and other parameters at dose dependent manner but the effect was less than the standard drug Atorvastatin. The results revealed the effectiveness of CF plant against hyperlipidemic activity.

show abstract

Section: Discussionsupporting

confidence: 75%

Screening of Different Leaf Extracts of Cassia fistula Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

Sutar¹,

Dass²,

Einstein

2014

ILNS

View full text Add to dashboard Cite

show abstract

“…The experiment was repeated three times. The difference in the absorbances between the test and the control were calculated and expressed as the percentage scavenging of DPPH radical (Jadhav & Bhutani, 2002).…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

Nephroprotective activity ofMomordica dioicaRoxb. in cisplatin-induced nephrotoxicity

Jain

Singhai

2010

Natural Product Research

View full text Add to dashboard Cite

In this study, the ethanol extract of Momordica dioica fruit extract (200 mg kg(-1)) was studied for nephroprotective and curative activities. Chloroform, ethyl acetate, ethanol and aqueous extracts were prepared. In vitro antioxidant activity was made the basis for the selection of the ethanol extract for further studies. In DPPH free radical scavenging activity, the ethanolic extract has shown maximum inhibition (84.2%), followed by aqueous (74.8%), ethyl acetate (69.4%) and chloroform (59.7%) extract. On the other hand, in total antioxidant activity, the ethanol extract has shown 80.1% inhibition, followed by aqueous (71.9%), ethyl acetate (67.2%) and chloroform (53.2%) extracts. A single dose (5 mg kg(-1), i.p.) of cisplatin was administrated to induce nephrotoxicity. Blood urea and serum creatinine were analysed as biochemical markers of nephrotoxicity. Reduced glutathione (GSH) and the product of lipid peroxidation (MDA) were also measured in kidney tissues. A single dose of cisplatin resulted in significant reduction in body weight and increased the urea and creatinine levels. Extract administration has shown significant recovery in the levels of these biochemicals in curative (p < 0.001) and protective groups, whereas a single dose of cisplatin caused significant reduction in GSH and an increase in malondialdehyde production. Recovery was observed in treated groups. This study suggested that the nephroprotective and curative activities of M. dioica fruit extract are due to its antioxidant activity. It is further concluded that this antioxidant activity may be attributed to the phenolics, flavonoids and amino acids present in the extract.

show abstract

“…Free radicals are harmful and cause oxidative stress which may cause very serious human diseases (Vani et al, 1997;Jadhav and Bhutani, 2002). Many natural products have been using in practice for the cure of free radicals (Kokate, 2004).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological evaluation of methanolic extract of Cyperus scariosus

Khan

Ahmed

et al. 2016

Bangladesh J Pharmacol

View full text Add to dashboard Cite

The present study is aimed to investigate the phytochemical screening and biological activities of methanolic extract of Cyperus scariosus roots. Dried plant was grounded and extracted with methanol to prepare methanol crud extract. In vitro biological tests were conducted using this methanolic extracts according to the standard procedure. 100% death rate of brine shrimp was perceived at 3 mg/mL of plant extract after 72 hours. The extract showed action against Aspergillus flavius i.e. 90% followed by A. niger (91%) while the highest activity was shown against A. fumegatrus (94%). Important scavenging results were detected during scavenging of free radicals viz; 92.2% against DPPH, 82.2% to ABTS, 75.8% to hydrogen peroxide, 88.1% to β-carotene, 86.1% to hydroxyl radical and 89.4% against phosphomolybdate at 3 mg/mL were obtained. The results obtained in this study point out that extract showed significant biological activities which might be due to the presence of bioactive constituents.

show abstract

Antioxidant properties of Indian medicinal plants

Cited by 52 publications

References 9 publications

Screening of Different Leaf Extracts of <i>Cassia fistula</i> Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

Screening of Different Leaf Extracts of <i>Cassia fistula</i> Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

Nephroprotective activity ofMomordica dioicaRoxb. in cisplatin-induced nephrotoxicity

Pharmacological evaluation of methanolic extract of <i>Cyperus scariosus</i>

Contact Info

Product

Resources

About