Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model

Ekşioğlu, Ümit; Atilgan, Hasan Ikbal; Yakin, Mehmet; Yazıhan, Nuray; Altiparmak, Uğur; Yumuşak, Nihat; Korkmaz, Meliha; Demir, Ayten; Örnek, Firdevs; Ayral, Pelin Aribal; Koca, Gökhan

doi:10.1080/15569527.2018.1498507

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…Neither vitamin A nor D have been used ex vivo, and no in vitro studies verify their radioprotective properties. Single use vitamin A was not utilized; however, it was for vitamin D [ 20 ], which demonstrated anti-inflammatory, antioxidant and radioprotective effects on lacrimal glands in histopathologic and tissue cytokine and oxidant/antioxidant level evaluations in rats. On the other hand, four reviewed vitamins were used in combination (vitamins C and E and β-carotene [ 15 ]; vitamins E and C [ 35 ]; vitamin A, C and E [ 36 ]; and vitamins A, E, C and over-the-counter multivitamins [ 37 ]) or other nutritional (selenium [ 16 ]; copper [ 17 ]; and magnesium sulphate [ 38 ]) and non-nutritional (Haberlea rhodopensis extract [ 18 ]; β-D-glucan [ 39 ]; curcumin [ 40 ]; famotidine and cimetidine [ 41 ]; famotidine [ 42 ]; melatonin [ 43 ]; amifostine and L-carnitine [ 44 ]; and Nigella sativa oil and melatonin [ 45 ]) compounds.…”

Section: Resultsmentioning

confidence: 99%

Vitamins and Radioprotective Effect: A Review

et al. 2023

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The radioprotective effect ex vivo, in vitro and in vivo of vitamins was reviewed using PubMed and Embase and conducted according to the PRISMA statement. A total of 38 articles were included in this review, which includes the radioprotective effect of vitamins from ex vivo, in vitro and in vivo studies. Vitamins A, C, D and E were used alone, in combination or with other nutritional and non-nutritional compounds. The use of vitamins in natural form or supplementation can be useful to reduce the radiation effect in the body, organs and/or cells. Only four (A, C, D and E) out of thirteen vitamins have been detected with radioprotective properties being mainly vitamin E followed by vitamin C, A and D.

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Section: Resultsmentioning

confidence: 99%

Vitamins and Radioprotective Effect: A Review

et al. 2023

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“…Within this frame, Eksioglu et al evaluated the antioxidant effects of active vitamin D against high-dose radioiodine therapy-associated oxidative damage of the lacrimal gland in Wistar albino rats. Radioiodine caused significant oxidative stress and inflammation in lacrimal glands and vitamin D could blunt these effects, thus showing anti-inflammatory, antioxidant and radio-protective effects [232]. As mentioned before, chronic inflammatory events further to immunologic activation have a pivotal role in dry eye pathogenesis, and vitamin D is known to have immunomodulatory properties [179].…”

Section: Vitamins D and Amentioning

confidence: 96%

Food Supplements in the Treatment of Ophthalmic Diseases: Preclinical and Clinical Studies

2020

J Pharmacol Pharm Res

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Among the 2.2 billion people in the world affected by any type of eye condition, the World Health Organization estimates 196 million with Age-related Macular Degeneration (AMD), 146 million with diabetic retinopathy (DR) and 76 million with glaucoma [1]. No clear estimate exists on the global presence of dry eye, though the English Agency known as Global-Data UK Ltd. in a document published on June 2018, considering the 8 more industrialised Countries (US,

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“…In rat models of DED, 2-hydroxy estradiol (2-OHE2), a catechol derivative of 17β-estradiol (E2), scavenges tyrosyl radicals and possibly suppresses oxidative stress in corneal epithelial cells, thereby suppressing corneal erosion [132]. The antioxidative effects of vitamin D have also been demonstrated in other studies using dry eye models [133,134]. In Sod1 −/− mice, tear function and ocular surface epithelial damage scores were significantly worse than in WT mice.…”

Section: Other Antioxidants In Protecting Against Dedmentioning

confidence: 99%

Potential New Target for Dry Eye Disease—Oxidative Stress

Bu,

Liu,

Zhang

et al. 2024

Antioxidants

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Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It is characterized by loss of tear film homeostasis and accompanied by ocular symptoms that may potentially result in damage to the ocular surface and even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, and lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, and ethanol consumption. As its prevalence continues to rise, DED has garnered considerable attention, prompting the exploration of potential new therapeutic targets. Recent studies have found that when the production of ROS exceeds the capacity of the antioxidant defense system on the ocular surface, oxidative stress ensues, leading to cellular apoptosis and further oxidative damage. These events can exacerbate inflammation and cellular stress responses, further increasing ROS levels and promoting a vicious cycle of oxidative stress in DED. Therefore, given the central role of reactive oxygen species in the vicious cycle of inflammation in DED, strategies involving antioxidants have emerged as a novel approach for its treatment. This review aims to enhance our understanding of the intricate relationship between oxidative stress and DED, thereby providing directions to explore innovative therapeutic approaches for this complex ocular disorder.

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Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model

Abstract: RAI caused significant oxidative stress and inflammation in lacrimal glands. Vitamin D demonstrated potent anti-inflammatory, antioxidant and radio-protective effects on lacrimal glands in histopathologic, tissue cytokine and oxidant/antioxidant level evaluations.

Cited by 11 publications

References 29 publications

Vitamins and Radioprotective Effect: A Review

Vitamins and Radioprotective Effect: A Review

Food Supplements in the Treatment of Ophthalmic Diseases: Preclinical and Clinical Studies

Potential New Target for Dry Eye Disease—Oxidative Stress

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