Antioxidant effects of resveratrol in the cardiovascular system

Abstract

This article is part of a themed section on Redox Biology and Oxidative Stress in Health and Disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.12/issuetoc.

Targeting vascular (endothelial) dysfunction

“…Several studies confirm that SIRT1 activity promotes eNOS expression/activity and improves endothelial cell survival and function (Lagouge et al , ; Mattagajasingh et al , ; Zhang et al , ). Clinical trials are underway to examine the potential benefits of resveratrol administration in subjects with cardiovascular disorders (Schleithoff et al , ; Xia et al , ). However, there are still unsolved safety concerns regarding the chronic consumption of high resveratrol doses (Tome‐Carneiro et al , ).…”

Antioxidants as therapeutics in the intensive care unit: Have we ticked the redox boxes?

“…Despite the fact that free radical scavenging became over years synonymous with the antioxidant function, it is important to note that antioxidants can exert their redox effects via non-scavenging activities as well [41,42]. Two representative examples are the "nucleophilic tone and para-hormesis" concept [43] and the removal of cysteine modifications [40].…”

Nutraceuticals: The New Generation Therapeutics

“…Upregulation of the tetrahydrobiopterin-synthesizing enzyme GTP cyclohydrolase I prevents superoxide production from uncoupled endothelial nitric oxide synthase. Moreover, the expressions of a variety of antioxidant enzymes are also increased by resveratrol [16].…”