Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells

Choi, Ji‐Won; Kang, Hyun Ju; Kim, Sung Zoo; Kwon, Tae Oh; Jeong, Seung-Il; Jang, Seon Il

doi:10.1007/s12272-013-0090-x

Cited by 84 publications

(53 citation statements)

References 23 publications

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“…Isoquercitrin has been reported to have antimicrobial (25) and antioxidant (26) effects. Astragalin has also been reported to have antioxidant (27) and anti-inflammatory (28) effects. The present study also identified quercetin from a minor peak (data not shown), but its contents in extract samples were far lower than those of the other compounds of interest, with a maximum concentration of 0.28 mg/g determined.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions

et al. 2014

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Abstract. Morus alba leaf (MAL), also known as Mori folium when used as a herbal medicine, has traditionally been used in Chinese medicine to treat diabetes, protect the liver and lower blood pressure. In the present study, MAL was collected from various regions in Korea and the antioxidant activity, total polyphenol contents and main flavonoid contents was investigated. MAL were collected from various areas in Korea and extracted with methanol. The total polyphenol contents were evaluated based on the Folin-Ciocalteu method using a spectrophotometer. The antioxidant activities were determined by a 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay method. The identification and quantification of three main polyphenol constituents was performed using high-performance liquid chromatography/diode array detection analysis. The total polyphenol contents of the MAL extracts varied between 23.2 and 55.4 mg gallic acid equivalent/g. The radical scavenging activity (SC 50 ) of the MAL extracts ranged between 584 and 139 µg/ml. Three flavonol compounds (rutin, isoquercitrin and astragalin) were identified as main polyphenol constituents. These contents varied from 0.68-12.7, 0.69-9.86 and 0.05-3.55 mg/g, respectively. The average of the total was 9.52 mg/g, which was similar to that of commercial MAL extracts (10.58 mg/g). Among the three flavonol compounds, isoquercitrin showed the highest content (5.68 mg/g) followed by rutin (3.1 mg/g) and astragalin (2.4 mg/g). In the present study, the radical scavenging activity, polyphenol content and flavonol content of MAL were significantly different according to growing area. These three flavonol compounds were identified as main constituents of MAL in this study, and are known to have various biological activities, as well as strong antioxidant activities. Therefore, the sum of these three flavonol compounds was indicated as a good marker for the quality control of Mori folium.

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Section: Discussionmentioning

confidence: 99%

Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions

et al. 2014

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“…The most abound compounds were ellagic acid, isoquercitrin and astragalin for NL and FL, with the contents of 52.62 70.05, 74.14 70.01, 71.21 70.01 mg/g and 33.73 70.33, 45.76 70.02, 25.437 0.03 mg/g, respectively. All the compounds had been proved with various bioactivities, including antioxidant and anti-inflammatory (Vattem and Shetty, 2005;Soromou et al, 2012;Choi et al, 2013;Valentova et al, 2014). Ellagic acid also exhibited anti-allergic activity in several models (Xue et al, 2012).…”

Section: Qualitative and Quantitative Analyses Of Nl And Flmentioning

confidence: 99%

Phenolic composition and effects on allergic contact dermatitis of phenolic extracts Sapium sebiferum (L.) Roxb. leaves

Zhang

Peng

et al. 2015

Journal of Ethnopharmacology

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“…It is widely found in tea and has been used to treat many diseases as a traditional Chinese medicine for a long time. Several groups have confirmed that AG exhibits a number of biological properties, including anti-inflammatory, antioxidant, and anti-atopic dermatitis effects [11–14]. In addition, AG can attenuate lipopolysaccharide (LPS)-induced inflammatory responses by suppressing the NF-кB signaling pathway [15].…”

Section: Introductionmentioning

confidence: 99%

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

et al. 2017

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Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. Here, we demonstrate that the flavonoid astragalin (AG), also known as kaempferol-3-O-β-D-glucoside, induces cell death. This was prevented by the caspase inhibitors z-DEVD-FMK and z-LEHD-FMK. AG-induced cell death was associated with an increase in the Bax:Bcl-2 ratio and amplified by the inhibition of extracellular signal-regulated kinase (ERK)-1/2 and Akt signaling. Meanwhile, AG suppressed LPS-induced NF-κB activation. Additional studies revealed that AG inhibited tumor necrosis factor-alpha (TNFα)-induced NF-κB activity. AG also potentiated TNFα-induced apoptosis in A549 cells. Furthermore, using a mouse xenograft model, we demonstrated that AG suppressed tumor growth and induced cancer cell apoptosis in vivo. Taken together, these results suggest that AG may be a promising cancer therapeutic drug that warrants further investigation into its potential clinical applications.

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Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells

Cited by 84 publications

References 23 publications

Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions

Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions

Phenolic composition and effects on allergic contact dermatitis of phenolic extracts Sapium sebiferum (L.) Roxb. leaves

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway

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