Antioxidant defense system in familial hypercholesterolemia and the effects of lipoprotein apheresis

Bláha, V.; Bláha, M.; Solichová, Dagmar; Krčmová, Lenka Kujovská; Lánska, M.; Havel, Eduard; Vyroubal, Pavel; Zadák, Z; Žák, Pavel; Sobótka, L.

doi:10.1016/j.atherosclerosissup.2017.05.002

Cited by 14 publications

(11 citation statements)

References 30 publications

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“…Since oxidative stress is believed to play a major pathogenic role in vascular disease, the impact of apheresis on oxidative stress parameters appears to be clinically important, especially considering patients with FH and hyperlipoproteinemia(a) are characterized by the intensification of prooxidative processes [30]. Our study showed a clear decrease in oxidative stress parameters after a single apheresis session, which is in line with previous studies showing a significant reduction in free oxygen radicals and an increase in free oxygen radical defense [11,14]. Nevertheless, not all studies have shown a positive impact of apheresis on systemic oxidative burden.…”

Section: Discussionsupporting

confidence: 90%

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The Impact of Lipoprotein Apheresis on Oxidative Stress Biomarkers and High-Density Lipoprotein Subfractions

Mickiewicz

Kreft

Kuchta

et al. 2020

Oxidative Medicine and Cellular Longevity

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Lipoprotein apheresis (LA) treatment results in a substantial reduction of low-density lipoprotein- (LDL-) cholesterol and lipoprotein(a) concentrations, which consequently decreases the rate of cardiovascular events. The additional benefit of LA may be associated with its impact on the composition and quality of high-density lipoprotein (HDL) particles, inflammation, and oxidative stress condition. To verify the effects of LA procedure, the current study is aimed at analyzing the effect of a single apheresis procedure with direct hemadsorption (DALI) and cascade filtration (MONET) on oxidative stress markers and HDL-related parameters. The study included eleven patients with familial hypercholesterolemia and hyperlipoproteinemia(a) treated with regular LA (DALI or MONET). We investigated the pre- and postapheresis concentration of the lipid-related oxidative stress markers 8-isoPGF2, oxLDL, TBARS, and PON-1. We also tracked potential changes in the main HDL apolipoproteins (ApoA-I, ApoA-II) and cholesterol contained in HDL subfractions. A single session of LA with DALI or MONET techniques resulted in a similar reduction of lipid-related oxidative stress markers. Concentrations of 8-isoPGF2 and TBARS were reduced by ~60% and ~30%, respectively. LA resulted in a 67% decrease in oxLDL levels along with a ~19% reduction in the oxLDL/ApoB ratio. Concentrations of HDL cholesterol, ApoA-I, ApoA-II, and PON-1 activity were also reduced by LA sessions, with more noticeable effects seen in the MONET technique. The quantitative proportions between HDL2 and HDL3 cholesterol did not change significantly by both methods. In conclusion, LA treatment with MONET or DALI system has a small nonselective effect on lowering HDL particles without any changes in the protein composition of these particles. Significant reduction in the level of oxidative stress parameters and less oxidation of LDL particles may provide an additional benefit of LA therapy.

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Section: Discussionsupporting

confidence: 90%

“…However, investigations on the effect of single apheresis procedures on oxidative stress parameters are rare and remain inconclusive. While some have shown that LA treatment can decrease oxidative stress biomarkers [11,14], others have demonstrated the enhancement of oxidative processes [15,16].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Lipoprotein Apheresis on Oxidative Stress Biomarkers and High-Density Lipoprotein Subfractions

Mickiewicz

Kreft

Kuchta

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…In addition, LA treatment is recognized as safe and can improve the prognosis of patients with progressive CVD . Besides effectively lowering plasma lipid levels, investigations of a single LA treatment on OS parameters, and on the relationship between blood lipids and these parameters were rare and remained conflicts …”

Section: Introductionmentioning

confidence: 99%

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Wen

Dong

et al. 2019

Clinical Laboratory Analysis

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Background and aims: Familial hypercholesterolemia (FH) characterized by severe high blood cholesterol levels usually presents an imbalance of systemic oxidative stress(OS).Lipoproteinapheresis(LA),whichisthemosteffectivetherapytoreduce cholesterollevels,remainsunclearinalteringOSandscarceinChinesepatientstudies. OurstudyaimstoassesstheimpactofLAonOSstatusinChinesepatientswithFH.Methods: About31patients(22males,age:12-69years)withFHandreceivingLA treatment were consecutive enrolled. Free oxygen radicals test (FORT) and free oxygen radicals defense (FORD) values were determined using the free oxygen radical monitor and kit immediately before and after LA, while blood samples were collected to measure plasma lipid levels and hs-CRP by conventional methods. Data were analyzed by paired ttestorranksumtestandSpearman-rhocorrelationanalysis.Results: Besides plasma lipid levels, the OS status showed that FORTs were significantly decreased and FORD values significantly enhanced immediately after LA treatment compared with before (both P < .01). In addition, the correlation analysis showed that the removal rates (△%) of TC were positively related to the increased rates (△%) of FORD value (ρ = 0.513, P = .003); LDL-C to FORD (ρ = 0.39, P = .03); Lp(a) to FORD (ρ=0.473,P=.007);andnon-HDL-CtoFORD(ρ = 0.46, P = .009). However,nosignificantdifferenceinhsCRPwasfound.Conclusions: The present study indicated, besides effectively lowering plasma lipid levels,LAcouldsignificantlyimproveOSstatusinChinesepatientswithFH. K E Y W O R D S familial hypercholesterolemia, lipoprotein apheresis, oxidative stressThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Lipoprotein apheresis is also a potent therapeutic player that impacts inflammation and related mediators. A large body of evidence on this is available ( Blaha et al, 2017b ; Stefanutti and Zenti, 2018 ).…”

Section: Treatment Considerationsmentioning

confidence: 99%

Genetics of Familial Hypercholesterolemia: New Insights

et al. 2020

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Familial hypercholesterolemia (FH) is one of the most common monogenic diseases, leading to an increased risk of premature atherosclerosis and its cardiovascular complications due to its effect on plasma cholesterol levels. Variants of three genes ( LDL-R , APOB and PCSK9 ) are the major causes of FH, but in some probands, the FH phenotype is associated with variants of other genes. Alternatively, the typical clinical picture of FH can result from the accumulation of common cholesterol-increasing alleles (polygenic FH). Although the Czech Republic is one of the most successful countries with respect to FH detection, approximately 80% of FH patients remain undiagnosed. The opportunities for international collaboration and experience sharing within international programs (e.g., EAS FHSC, ScreenPro FH, etc.) will improve the detection of FH patients in the future and enable even more accessible and accurate genetic diagnostics.

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Antioxidant defense system in familial hypercholesterolemia and the effects of lipoprotein apheresis

Cited by 14 publications

References 30 publications

The Impact of Lipoprotein Apheresis on Oxidative Stress Biomarkers and High-Density Lipoprotein Subfractions

The Impact of Lipoprotein Apheresis on Oxidative Stress Biomarkers and High-Density Lipoprotein Subfractions

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Genetics of Familial Hypercholesterolemia: New Insights

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