Antioxidant capacity of extracts and isolated compounds from Stryphnodendron obovatum Benth

Zocoler, Analice Martins Daleffi; Sanches, Andréia Cristina Conegero; Albrecht, Ingrid; Mello, João Carlos Palazzo de

doi:10.1590/s1984-82502009000300009

Cited by 17 publications

(8 citation statements)

References 30 publications

(37 reference statements)

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“…S. coriaceum exhibits acetylcholinesterase inhibitory activity, as well as antioxidant, anti-inflammatory, antimicrobial, healing, antiulcerogenic, and leishmanicidal activities [ 35 , 36 ]. The S. coriaceum extract was shown to have excellent acetylcholinesterase inhibitory and antioxidant activities, which make it another potential source of therapeutic agents against AD.…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease

Penido

Morais

Ribeiro

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Alzheimer's disease (AD) has been linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes. In the northeast region of Brazil, various plants are used to treat several diseases associated with these processes; then an antioxidant test was performed with those plants in a previous work and twelve species with higher antioxidant activity were selected for AChE inhibition evaluation. The phenolic compounds content was determined by Folin–Ciocalteu test and flavonoid content with AlCl3 reagent using UV-visible spectrophotometry. The antioxidant activity was assessed analyzing the inhibitory activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonate (ABTS) and by the β-carotene/linoleic acid system and acetylcholinesterase inhibition using qualitative and quantitative tests. The combination of better acetylcholinesterase inhibitory and antioxidant activities pointed out six species, in descending order, as the best potential sources of therapeutic agents against AD: Hancornia speciosa > Myracrodruon urundeuva > Copaifera langsdorffii > Stryphnodendron coriaceum > Psidium guajava > Mangifera indica. Besides, the phenolic compounds in the species probably contribute to these activities. However, further pharmacological studies to assess the specific applications of these plants against AD are required to confirm these results.

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Section: Resultsmentioning

confidence: 99%

Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease

Penido

Morais

Ribeiro

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Zocoler et al [65] demonstrated a strong relationship between anti-inflammatory activity of the Stryphnodedron obovatum with the presence of gallic acid, epigallocatechin, and gallocatechin. Araújo-Neto et al [66] have shown the anti-inflammatory effect of tannins and flavonoids in studies with Sideroxylon obtusifolium on paw edema induced by carrageenan and peritoneal leukocyte infiltrate in rats.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Phenolic Compounds and Anti-Inflammatory Activity of Ethyl Acetate Phase of Anacardium occidentale L. Bark

et al. 2016

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Abstract:The bark of A. occidentale L. is rich in tannins. Studies have described various biological activities of the plant, including antimicrobial, antioxidant, antiulcerogenic and antiinflammatory actions. The objective of this study was to assess the activity of the ethyl acetate phase (EtOAc) of A. occidentale on acute inflammation and to identify and quantify its phenolic compounds by HPLC. The method was validated and shown to be linear, precise and accurate for catechin, epicatechin, epigallocatechin and gallic acid. Swiss albino mice (Mus musculus) were treated with saline, Carrageenan (2.5%), Indomethacin (10 mg/kg), Bradykinin (6 nmol) and Prostaglandine E2 (5 µg) at different concentrations of EtOAc -A. occidentale (12.5; 25; 50; and 100 mg/kg/weight p.o.) for the paw edema test. Challenge was performed with carrageenan (500 µg/mL i.p.) for the doses 50 and 100 mg/kg of EtOAc. Levels of cytokines IL-1, TNF-α, IL-6 and IL-10 were also measured. All EtOAc -A. occidentale concentrations reduced the edema. At 50 and 100 mg/kg, an anti-inflammatory response of the EtOAc was observed. Carrageenan stimulus produced a neutrophil count of 28.6% while 50 and 100 mg/kg of the phase reduced this to 14.5% and 9.1%, respectively. The EtOAc extract reduced levels of IL-1 and TNF-α. These results suggest that the EtOAc plays a modulatory role in the inflammatory response. The chromatographic method can be used for the analysis of the phenolic compounds of the EtOAc phase.

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“…Among such phenols, the most common have been gallic acid, p-hydroxybenzoic acid, catechin derivatives and tannins isolated from acetone : water (7 : 3 v/v) and ethyl acetate extracts. 2,7,8 Numerous experimental and epidemiological studies have also shown that phenolics, avonoids and catechin derivatives are commonly found in Stryphnodendron spp, and these constituents are normally described as antioxidants. 9,10 Polyphenols and derivatives in plant extracts have been determined mainly via chromatographic protocols, but more recently direct infusion electrospray ionization mass spectrometry (ESI-MS) has been increasingly used to obtain proles of phenolic compounds from plant extracts, particularly when the elemental composition can be inferred from the MS measurements.…”

Section: Introductionmentioning

confidence: 99%