Antioxidant, Anticancer, Antimicrobial, and Antibiofilm Properties of the Culinary-Medicinal Fairy Ring Mushroom, Marasmius oreades (Agaricomycetes)

Shomali, Naznoosh; Onar, Okan; Karaca, Başar; Demirtaş, Nergiz; Cihan, Arzu Çöleri; Akata, İlgaz; Yıldırım, Özlem

doi:10.1615/intjmedmushrooms.2019030874

Cited by 18 publications

(15 citation statements)

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“…Accumulating evidence obtained from in vitro, experimental animal, and clinical studies supports the protective role of mushroom-derived compounds against cancer [22,43,47]. For example, reports are showing that extracts from the mushroom Phellinus linteus block the proliferation of human lung, liver, kidney, and brain cancer cells and that the ethanol extracts from the fairy-ring mushroom Marasmius oreades inhibit the growth of human breast cancer cells and human colorectal adenocarcinoma cells [48,49]. Furthermore, preclinical studies showed that dietary supplementation of the fungus Agaricus blazei suppresses tumor growth, and in humans, a recent meta-analysis demonstrated that higher mushroom consumption is associated with a lower risk of developing cancer [50,51].…”

Section: Discussionmentioning

confidence: 99%

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma

Inoue

Yasuma

D’Alessandro-Gabazza

et al. 2022

Cells

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The leading cause of death worldwide is cancer. Many reports have proved the beneficial effect of mushrooms in cancer. However, the precise mechanism is not completely clear. In the present study, we focused on the medicinal properties of biomolecules released by fairy ring-forming mushrooms. Fairy chemicals generally stimulate or inhibit the growth of surrounding vegetation. In the present study, we evaluated whether fairy chemicals (2-azahypoxanthine, 2-aza-8-oxohypoxanthine, and imidazole-4-carboxamide) exert anticancer activity by decreasing the expression of Axl and immune checkpoint molecules in melanoma cells. We used B16F10 melanoma cell lines and a melanoma xenograft model in the experiments. Treatment of melanoma xenograft with cisplatin combined with imidazole-4-carboxamide significantly decreased the tumor volume compared to untreated mice or mice treated cisplatin alone. In addition, mice treated with cisplatin and imidazole-4-carboxamide showed increased peritumoral infiltration of T cells compared to mice treated with cisplatin alone. In vitro studies showed that all fairy chemicals, including imidazole-4-carboxamide, inhibit the expression of immune checkpoint molecules and Axl compared to controls. Imidazole-4-carboxamide also significantly blocks the cisplatin-induced upregulation of PD-L1. These observations point to the fairy chemical imidazole-4-carboxamide as a promising coadjuvant therapy with cisplatin in patients with cancer.

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Section: Discussionmentioning

confidence: 99%

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma

Inoue

Yasuma

D’Alessandro-Gabazza

et al. 2022

Cells

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“…The in vivo study showed a reduction in solid Ehrlich tumor mass after 5 days of exposure to metabolites. Researchers studied the ethanol extract of Marasmius oreades on the HT-29, MCF-7, and MDA-MB-231 cells by using MTT assay [ 82 ]. Anticancer activities of mushroom extract of other researchers have been cited in Table 3 .…”

Section: Pharmacological Actions Of Mushroommentioning

confidence: 99%

Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product

Chopra

Mishra

Baig

et al. 2021

JoF

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Mushrooms have remained an eternal part of traditional cuisines due to their beneficial health potential and have long been recognized as a folk medicine for their broad spectrum of nutraceuticals, as well as therapeutic and prophylactic uses. Nowadays, they have been extensively investigated to explain the chemical nature and mechanisms of action of their biomedicine and nutraceuticals capacity. Mushrooms belong to the astounding dominion of Fungi and are known as a macrofungus. Significant health benefits of mushrooms, including antiviral, antibacterial, anti-parasitic, antifungal, wound healing, anticancer, immunomodulating, antioxidant, radical scavenging, detoxification, hepatoprotective cardiovascular, anti-hypercholesterolemia, and anti-diabetic effects, etc., have been reported around the globe and have attracted significant interests of its further exploration in commercial sectors. They can function as functional foods, help in the treatment and therapeutic interventions of sub-optimal health states, and prevent some consequences of life-threatening diseases. Mushrooms mainly contained low and high molecular weight polysaccharides, fatty acids, lectins, and glucans responsible for their therapeutic action. Due to the large varieties of mushrooms present, it becomes challenging to identify chemical components present in them and their beneficial action. This article highlights such therapeutic activities with their active ingredients for mushrooms.

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“…The two fractions impaired p65 nuclear translocation and inhibited the IkappaB kinase (IKK) activation pathway leading to NF-kappaB activation and apoptosis of MCF7 cells (Petrova et al 2009). The ethanolic extract of M. oreades from Turkey exhibited a diversity of phenolics such as vanillic acid, gallic acid, ferulic acid, and catechin showed a moderate anticancer activity on MDA-MB-231 and MCF-7 cells (Shomali et al 2019).…”

Section: Marasmius Oreadesmentioning

confidence: 99%

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Wong

Chan

et al. 2020

Appl Microbiol Biotechnol

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This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew's ear (black) fungus or black wood ear fungus Auricularia auricula-judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep's head mushroom Grifola frondosa, lion's mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese "meshimakobu," Chinese "song gen," Korean "sanghwang," American "black hoof mushroom"), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. Agaricus placomycesThe 68-kDa laccase from Agaricus placomyces belongs to a family of copper-containing oxidases involved in lignin degradation and possessing anticancer activity (Mizerska-Dudka et al. 2015). It potently expressed antiproliferative activity toward MCF-7 human breast cancer cells with an IC50 of 1.8 μM (Sun et al. 2012). Agaricus sylvaticusIn a randomized, double-blind, and placebo-controlled clinical trial, 46 patients with stage II and III breast cancer who received chemotherapy demonstrated an improved appetite and fewer gastrointestinal complaints, nausea, and vomiting following dietary supplementation with A. sylvaticus (2.1 g/day) (Valadares et al. 2013). Amauroderma rude Amauroderma rude had higher tumoricidal activity than Ganoderma lucidum. A. rude lowered cell survival and triggered apoptosis in MDA-MB-231 breast cancer cells. Tumor growth in athymic nude mice bearing MDA-MB-231-xenografts was retarded and tumor cell death was promoted by treatment with A. rude. Expression of the c-Myc oncogene was downregulated . A. rude exhibited a higher content of ergosterol (ergosta-5,7,22-trien-3β-ol) in comparison with 12 other mushrooms examined. Under the influence of ergosterol, the viability of MDA-MB-231 breast cancer cells was reduced, whereas expression of the tumor suppressor Foxo3 and downstream signaling molecules including BimL, BimS, Fas, and FasL was enhanced resulting in apoptosis of the breast cancer cells (Li et al. 2015).Amauroderma rugosum (also known as black Lingzhi, a member of five-color Lingzhi) Organic molecules from A. rugosum inhibited oxidant activity, tumor necrosis factor-α and nitric oxide formation, and MCF7 cell proliferation (Zhang et al. 2017a). A single treatment with pulverized A. rugosum (2000 mg/kg) by mouth did not impair growth, blood parameters, histological structures of t...

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Antioxidant, Anticancer, Antimicrobial, and Antibiofilm Properties of the Culinary-Medicinal Fairy Ring Mushroom, Marasmius oreades (Agaricomycetes)

Cited by 18 publications

References 0 publications

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma

Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

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