Antioxidant, Anti-Glycation and Anti-Inflammatory Activities of Phenolic Constituents from Cordia sinensis

Abstract

Nine compounds have been isolated from the ethyl acetate soluble fraction of C. sinensis, namely protocatechuic acid (1), trans-caffeic acid (2), methyl rosmarinate (3), rosmarinic acid (4), kaempferide-3-O-β-D-glucopyranoside (5), kaempferol-3-O-β-D-glucopyranoside (6), quercetin-3-O-β-D-glucopyranoside (7), kaempferide-3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (8) and kaempferol-3-O-α-L-rhamno-pyranosyl (1→6)-β-D-glucopyranoside (9), all reported for the first time from this species. The structures of these compounds were deduced on the basis of spectroscopic studies, including 1D and 2D NMR techniques. Compounds 1–9 were investigated for biological activity and showed significant anti-inflammatory activity in the carrageen induced rat paw edema test. The antioxidant activities of isolated compounds 1–9 were evaluated by the DPPH radical scavenging test, and compounds 1, 2, 4 and 7–9 exhibited marked scavenging activity compared to the standard BHA. These compounds were further studied for their anti-glycation properties and some compounds showed significant anti-glycation inhibitory activity. The purity of compounds 2–5, 8 and 9 was confirmed by HPLC. The implications of these results for the chemotaxonomic studies of the genus Cordia have also been discussed.

The genus Cordia: botanists, ethno, chemical and pharmacological aspects

“…C. macleodii and C. nodosa have a wide distribution in tropical America (Izzo and PetInI-BenellI, 2011). C. sinensis, C. superba and C. thaisiana are found in the drier areas of India, Africa and Saudi Arabia (Al-Musayeib et al, 2011;Araque et al, 2009). C. abyssinica, C. africana, C. alliodora are species that have wood utilized in production of high-quality furniture and other objects and domestic utensils.…”

“…C. rufescens is used in medicine popular as an abortifacient and antiinflammatory (Costa et al, 2008). The stem bark of C. sinensis is used in traditional medicine for the treatment of gastric and respiratory disturbances (Al-Musayeib et al, 2011). C. globosa is utilized in traditional medicine in Paraiba State, Brazil for digestive problems, rheumatism and menstrual colic.…”

“…E.F.F. Matias et al / Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx (Al-Musayeib et al, 2011;Bayeux et al, 2002;Bhattacharya and Saha, 2013;Caparroz-Assef et al, 2008;Cardozo et al, 2008;Costa et al, 2008;Matias et al, 2010bMatias et al, , 2013aPanghal et al, 2011b;Salazar-Aranda et al, 2011;Ticli et al, 2005).…”

Anatomical study of vegetative parts and Powder microscopy of Cordia myxa L. (Boraginaceae) in Iraq

“…All the parts of this plant used as popular medicine when the stem bark of Cordia is used in traditional medicine for the treatment of gastric and respiratory disturbances [5]. In the Alagoas State, the leaves and flowers are used as treatment of hemorrhaging, throat infections and cold [6], also the leaves and roots of Cordia are used in folk medicine for digestive disturbances, rheumatism and as a generaltonic [7], besides the treatment of symptoms of menstrual colic and dyspepsia [8]- [9]- [10], so the leaves and stem of Cordia are used for various superficial inflammatory processes in wound areas and general inflammations and also as an analgesic for menstrual colic [11]. The survey concluded that no anatomical studies were carried on this genus in Iraq or abroad.…”

Exploring Phytochemicals and Pharmacological Uses of Cordia Dichotoma (Indian Cherry): A Review

“…4-hydroxy-transcinnamate ester 8,13 , β-sitosterol 4,14 , quercetin and quercitrin 11,15 ). Preliminary phytochemical analysis of C. dichotoma bark indicated the presence of allantoin, β-sitosterol and 3', 5-dihydroxy-4'-methoxy flavanone-7-O-alpha-L-rhamnopyranoside 4,16 .…”