Antioxidant and Immuno-Enhancing Effects of Echinacea purpurea

Mishima, Satoshi; Saito, Kiyoto; Maruyama, Haruhiko; Inoue, Makoto; Yamashita, Takahiro; Ishida, Tatsuro; Gu, Yeunhwa

doi:10.1248/bpb.27.1004

Cited by 77 publications

(58 citation statements)

References 17 publications

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“…The cause of this effect is likely due to antioxidants in E. purpurea, such as echinacoside and caffeic acid (20). Echinacea is an antioxidant agent effective in eliminating free radicals produced by irradiation with its radical-scavenging effect, reducing cytotoxicity caused by lipid peroxides due to oxidization, and preventing impairment of immunity in mice exposed to radiation (21).…”

Section: Discussionmentioning

confidence: 99%

The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid

Doğan¹,

Ergül²,

Sarıkaya³

et al. 2014

BLL

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Abstract:Background: Ulcerative colitis is a chronic infl ammatory condition of the colon, and reactive oxidative metabolites (ROMs) play an important role in its pathogenesis. Alternative therapies such as herbal remedies are increasingly being used in the treatment of ulcerative colitis for better clinical outcome of ulcerative colitis and less adverse effects. Echinacea has many features including antioxidant and wound-healing properties. Hence, the present study was undertaken to evaluate the protective effect of Echinacea spp. on experimental colitis model induced by acetic acid in Wistar albino rats. Methods: Acute colitis was induced by intrarectal administration of acetic acid. Rats were divided into four groups, namely control, Echinacea-administered, Echinacea-administered-colitis and colitis. Malondialdehyde and total antioxidant status were assayed in tissue samples. Histopathological evaluation was also performed. Results: Macroscopic and microscopic scores were signifi cantly higher in colitis group compared to control, Echinacea and Echinacea-colitis groups (p < 0.001). There was no signifi cant differences in respect of macroscopic and microscopic scores between control, Echinacea and Echinacea-colitis groups (p > 0.3, p > 0.22). Malondialdehyde levels were elevated in colitis group compared to other groups (p < 0.001). Total antioxidant status was signifi cantly higher in Echinacea group compared with other groups and also signifi cantly higher in Echinacea-colitis group compared with colitis group (p < 0.001, p < 0.001, respectively). Conclusion: Echinacea may possibly have some therapeutic usefulness in the management of ulcerative colitis (Tab. 2, Fig. 4, Ref. 35). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid

Doğan¹,

Ergül²,

Sarıkaya³

et al. 2014

BLL

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“…Easter purple coneflower, a plant rich in polysaccharides, phytosterols, phenolic compounds and caffeic acid derivatives has been reported to possess multifunctional effects, namely immunostimulating, antiinflammatory, antivirus, anticancer and radioprotective, as well as possible antiandrogenic activities (Mishima et al, 2004;Dorsch, 1996;Skaudickas et al, 2003Skaudickas et al, , 2004. In addition, it should be noted that the roots of coneflower contain some other active substances that could affect the prostate function (Bauer, 1996).…”

Section: Introductionmentioning

confidence: 99%

The effect of Echinacea purpurea (L.) Moench extract on experimental prostate hyperplasia

Skaudickas

Kondrotas

Kėvelaitis

et al. 2009

Phytotherapy Research

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The aim of this study was to examine the effect of purple coneflower (Echinacea purpurea L. Moench) on the prostate gland of rats using an experimental model of benign prostate hyperplasia (BPH). The animals were administered 50 mg/kg of extract preparation for 4 and 8 weeks and the prostate mass and structural degenerative changes were evaluated in the course of the experiment. The administration of E. purpurea extract to rats with hyperplasia for 4 and 8 weeks gradually and significantly reduced the prostate mass and reversed the degenerative changes in the structure of the prostate gland. The present investigation suggests extract of purple coneflower prevents the development of BPH.

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“…In addition, this drug stimulates macrophages and increases cytokine production specially interferon gamma. Also, E. purpurea stimulates proliferation of T lymphocytes and enhances cellular immunity (Freier et al 2003;Mishima et al 2004;Satoshi et al 2004). In our study, we demonstrated prophylactic effect of E. purpurea on pallet cleft produced by phenytoin in the foetus of mice (Khaksary Mahabady et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect ofEchinacea purpureaon antibody production against fowl influenza vaccine

Najafzadeh

Ghorbanpour

Mayahi

et al. 2011

Journal of Applied Animal Research

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To study, the effect of Echinacea on production of antibody against avian influenza vaccine, 100 chickens were divided into four groups: A as negative control, B as positive control (received influenza vaccine H9N2 at the 8th day of the study), C as B in addition to Echinacea at dose of 0.1% of diet for 2 weeks, D as C but Echinacea at dose of 0.5% of diet. Blood of chickens was collected at day 0, 8, 21 and 42 of the study. The titre of antibody against influenza vaccine was measured by ELISA and haemagglutination inhibition (HI) methods. Echinacea increased (PB0.05) the titre of antibody in comparison to controls and dose of 0.5% had a better effect than 0.1% in ELISA test. Thus, Echinacea having an enhancing effect on efficiency of influenza vaccine, can be useful in prevention of avian influenza.

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Antioxidant and Immuno-Enhancing Effects of Echinacea purpurea

Cited by 77 publications

References 17 publications

The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid

The antioxidant effect of Echinacea angustifolia and Echinacea purpurea in rat colitis model induced by acetic acid

The effect of Echinacea purpurea (L.) Moench extract on experimental prostate hyperplasia

Effect ofEchinacea purpureaon antibody production against fowl influenza vaccine

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