Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide- induced acute liver damage in mice

Kalantari‬, Heibatullah; Foruozandeh, Hossein; Khodayar, Mohammad Javad; Siahpoosh, Amir; Saki, Najmaldin; Kheradmand, Parvin

doi:10.1016/j.jtcme.2017.04.010

Cited by 65 publications

(49 citation statements)

References 42 publications

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“…Treatment with plant extract, rutin and hesperidin reduced most of the pathological alterations induced by EAC cells in mice , there is no appearance of solid carcinoma of aggregated malignant cells.As for preventive plant extract group the liver tissue showed normal hepatic parenchyma; hepatocytes, blood sinusoids, and Portal tract, While for the therapeutic plant extract group, Liver showing hepatocytes vacuolation with prepheral nucleous, the central vein is permeated with leucocytic cells . Our results showed hepatoprotective effect of C. spinosa extract were supported by the study that revealed histopathological studies under light microscope confirms the protective effects of C. spinosa and Quercetin against the t-BHPinduced liver damage [93] .…”

Section: Catalase Is a Hemoprotein And It Protects Cells From The Accsupporting

confidence: 82%

Assessment of antiproliferative activity of Capparis spinosa L extract against Ehrlich ascites carcinoma in Swiss albino mice

Mohammed

Gurigis

Gamal

2018

Biochemistry Letters

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Background: Medicinal plants have been known as one of the most important therapeutic agents for cancer treatment and prevention. Capparis spinosa L is a multipurpose plant that contains different bioactive phytochemicals including phenols and flavonoids.Aims: In the present study we explore the invivo antitumor activity of Capparis spinosa L extract and most potent constituents rutin and hesperidin against Ehrlich ascites carcinoma (EAC). Also study the side effect of treatments on different organs (liver, kidney and heart). Material and method: The antitumor effect was assessed by evaluating tumor volume , tumor cell count , survival time and increase in life span of EAC bearing mice. We assessed the effect of Capparis spinosa L extract , rutin and hesperidin on the level of malonaldialdhyde (MDA) and Catalase activity. Also, we estimated their effect on Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) , Albumin , urea , creatinine ,Lactate dehydrogenase activity (LDH), Creatine Kinase-MB activity (CK-MB). Apoptosis was assessed by BCL2 and caspase3 activity. Results : The Capparis spinosa L extract , rutin and hesperidin showed significantly decreased (p<0.001) in the volume of the EAC and in the count of EAC cells and increase the life span of EAC bearing mice. The treatment with Capparis spinosa L extract , rutin and hesperidin showed significantly decreased (p<0.001) the lipid peroxidation marker (MDA) and recovered catalase activity towards normal as compared to positive control. We founded that Capparis spinosa L extract , rutin and hesperidin treatment induced apoptosis demonstrated by an increased in Caspase 3 activity and decreased in BCL2 .The treatment of Capparis spinosa L extract , rutin and hesperidin significantly reduced the elevated levels of ALT , AST ,LDH ,CK-MB,Urea and Creatinine in positive control as compared with negative control. Also, they showed protection for both liver and kidney histopathologically. Conclusions: The present study demonstrated that Capparis spinosa L extract , rutin and hesperidin have potent antitumor activity against Ehrlich ascites carcinoma. The anti-tumor mechanism may be mediated by preventing oxidative damage and induction of apoptosis.

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Section: Catalase Is a Hemoprotein And It Protects Cells From The Accsupporting

confidence: 82%

Assessment of antiproliferative activity of Capparis spinosa L extract against Ehrlich ascites carcinoma in Swiss albino mice

Mohammed

Gurigis

Gamal

2018

Biochemistry Letters

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“…Tesoriere et al () reported that caper bud ( C. spinosa ) contained 48.75 mg GAE/100 g. Germanò et al () determined that caper buds have number of flavonoids and other polyphenols. Total phenol contents of hydro‐alcoholic, ethyl acetate, and chloroform extracts obtained from Capparis spinosa leaves were established as 26.59 and 13.66 mg/g, respectively (Kalantari et al, ). Kalantari et al () reported that C. spinosa leave extracts contained 7.415 mg/g (hydro‐alcholic extract), 2.897 mg/g (ethyl acetate ectract), and 4.…”

Section: Resultsmentioning

confidence: 99%

“…Total phenol contents of hydro‐alcoholic, ethyl acetate, and chloroform extracts obtained from Capparis spinosa leaves were established as 26.59 and 13.66 mg/g, respectively (Kalantari et al, ). Kalantari et al () reported that C. spinosa leave extracts contained 7.415 mg/g (hydro‐alcholic extract), 2.897 mg/g (ethyl acetate ectract), and 4. 986 mg/g (chloform extract) flavonoid.…”

Section: Resultsmentioning

confidence: 99%

“…986 mg/g (chloform extract) flavonoid. Kalantari et al () determined 0.0349, 0.2770, and 0.0392 mg/ml antioxidant values in hydro‐alcholic, ethyl acetate, and chloroform extracts of C. spinosa leaves, respectively. Grimalt, Hernández, Legua, Almansa, and Amorós () reported that total phenol contents of caper fruits changed between 61.5 and 119.2 mg GAE/100 g (fw).…”

Section: Resultsmentioning

confidence: 99%

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Bioactive properties and phenolic compounds in bud, sprout, and fruit ofCapparisspp. plants

Ghafoor

Juhaimi

Özcan

et al. 2020

J Food Process Preserv

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In this study, changes in bioactive properties and phenolic compounds of different caper parts were reported. Total phenolic contents of C. ovata and C. spinosa plants varied between 175.35 mgGAE/100 g (fruit) and 518.4 mgGAE/100 g (small bud) to 143.58 mgGAE/100 g (fruit and 597.57 mgGAE/100 g (small bud), respectively. While total flavonoid contents of C. ovata parts vary between 9.12 mg/g (fruit) and 37.22 mg/g (small bud), total flavonoid contents of C. spinosa parts changed between 7.43 mg/g (fruit) and 62.39 mg/g (small bud). Antioxidant activity values of C. ovata and C. spinosa parts varied between 53.43% (sprout) and 76.40% (medium bud) to 50.51% (fruit) and 76.65% (medium bud), respectively. While (+) catechin contents of C. ovata parts change between 22.16 mg/100 g (fruit) and 149.13 mg/100 g (small bud), (+)‐catechin contents of C. spinosa parts varied between 65.50 mg/100 g (fruit) and 99.29 mg/100 (small bud). 1,2‐Dihydroxybenzene contents of C. ovata ranged from 33.4 mg/100 g (fruit) to 142.41 mg/100 g (small bud) while 1,2‐dihydroxybenzene contents of C. spinosa parts are found between 75.17 mg/100 g (fruit) and 127.32 mg/100 g (medium bud). Practical applications Caper plant grows at the most countries of Africa, Asia, and South European. Capers have very important roles for beneficial natural components in the food industry. Caper buds and fruits are used for human nutrition. It is utilized to prepare salada as a culinary herb. Caper has pungent and bitter flavor, and are used as an appetizer with olives, cheese, and nuts. There are a significant increase in the interest of bioactive compounds from plant products. Curative and medicinal properties of capers are linked to the presence of bioactive compounds.

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“…Spleen and liver are considered the main organs that control dyslipidemia. One study has demonstrated major roles of caper, including its hepatoprotective, hypolipidemic, antidiabetic, antioxidant, and anti-inflammatory effects [6]. The blood glucose-lowering effect of caper is due to a reduction in carbohydrate absorption in the intestine, increase in glucose uptake in tissues, glucose depletion from the liver, and regeneration of beta cells of the pancreas [7,8].…”

Section: Introductionmentioning

confidence: 99%

Daily consumption of caper fruit along with atorvastatin has synergistic effects in hyperlipidemic patients: Randomized clinical trial

Sardari

Fallahi

Emadi

et al. 2019

GMJ

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Background: Dyslipidemia leads to micro-and macro-vascular complications. Atorvastatin is the main therapeutic drug used for dyslipidemia, but it causes side effects such as new type 2 diabetes mellitus onset and elevation of liver enzymes. Herbs may be useful in reducing atorvastatin doses. Caper fruit, an herbal drug in Persian Medicine, has hypolipidemic effects. Hence, the effect of atorvastatin therapy with and without daily caper fruit pickle (CFP) consumption was assessed on hyperlipidemia. Materials and Methods: In this single-blinded, randomized, controlled trial, 60 hyperlipidemic patients were allocated in two groups and treated with 10 mg atorvastatin plus 40-50 g CFP (A10+CFP) or atorvastatin alone (A10) for eight weeks. Biochemical parameters were measured at baseline, 4, and eight weeks of the intervention. One-way repeated measure ANOVA and mixed ANOVA were used to measure the effect of the two treatments and the interaction between the type of treatment and time on lipid profile. Results: Serum total cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly decreased in the A10+CFP group compared with the A10 group (P<0.001 and P<0.001, respectively) from baseline up to the week 8. At week 4, mean changes of LDL-C was significantly higher in the A10+CFP compared with the A10 (P=0.01). Adjusting for the baseline variables, the mean difference of alanine aminotransferase (P<0.01) and triglyceride (P=0.003) were significantly higher in the A10+CFP group at the end. Conclusion: This study reports that the intake of CFP along with atorvastatin daily may have synergistic effects which improve the lipid profile in hyperlipidemic patients. [GMJ.2019;8:e1345]

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Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide- induced acute liver damage in mice

Cited by 65 publications

References 42 publications

Assessment of antiproliferative activity of Capparis spinosa L extract against Ehrlich ascites carcinoma in Swiss albino mice

Assessment of antiproliferative activity of Capparis spinosa L extract against Ehrlich ascites carcinoma in Swiss albino mice

Bioactive properties and phenolic compounds in bud, sprout, and fruit ofCapparisspp. plants

Daily consumption of caper fruit along with atorvastatin has synergistic effects in hyperlipidemic patients: Randomized clinical trial

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