Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds

Cardiotoxicity and myocardial infarction‐associated DNA damage induced by thiamethoxam in vitro and in vivo: Protective role of Trigonella foenum‐graecum seed‐derived polysaccharide

“…Co‐treatment with FWEP increased cell viability, suggesting that polysaccharide could protect cardiomyocytes against exogenous compounds. In the same trend, our previous studies, conducted in our laboratory, demonstrated that FWEP exhibited a strong DPPH free radical scavenging activities and ferric reducing power capacities . These results suggested that FWEP could potentially be used as a natural antioxidant and exert a direct cardioprotective effect against agrochemical‐induced toxicity.…”

“…Meanwhile, the obtained results proved that co‐treatment with FWEP ameliorated the status of TMX‐induced cardio toxicity in rats through maintaining cardiac biomarker enzymes to a near normal condition. This underlines that FWEP is responsible for the protection of the structural and architectural integrity of cardiomyocytes by preventing lipid peroxidation owing to its ability to scavenge superoxide and hydroxyl radicals as reported by our in vitro study through via FWEP linoleate model system confirmed by Ktari et al In this regard, previous investigations demonstrated that polysaccharide could correct dyslipidemia, improve TG metabolism, enhance endothelial function, increase antioxidant potential and decrease LDL …”

“…The continuous use of chemical inputs such as pesticides has resulted in great damage to the environment in addition to human ill‐health. The clinical impact of pesticides is marked by an increasing risk of myocardial injury and congestive heart failure, chiefly caused by reactive oxygen species generation . However, many studies have reported the benefits of medicinal plants in the treatment of cardiovascular diseases due to their richness in bioactive compounds.…”

“…The treatments were carried out for a period of 30 days. The dose duration of TMX treatment was previously shown to be toxic but not lethal . The doses of FWEP (100 mg/kg and 200 mg/kg of diet) were shown in previous studies to be effective in lowering toxicity …”

“…Recent studies carried out in our laboratory demonstrated that a polysaccharide extracted from fenugreek seeds, named fenugreek seed water polysaccharide (FWEP), corresponded to a gluconic acid polymer with semi‐crystalline structure as demonstrated by spectroscopic analyses by FT‐IR, XRD, HPLC, and NMR. It exhibited also strong antioxidant activities when incorporated in beef sausages, and accelerated the re‐epithelialization and wound closure in the full‐thickness of the excisional model in rats …”