Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice

Aydın, Sevtap; Tokaç, Mehmet; Taner, Gökçe; Arıkök, Ata Türker; Dündar, Halit Ziya; Özkardeş, Alper Bilal; Taşlıpınar, Mine Yavuz; Kılıç, Mehmet; Başaran, Arif Ahmet; Başaran, Nurşen

doi:10.1016/j.jss.2012.10.031

Cited by 27 publications

(17 citation statements)

References 68 publications

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“…Chronic administration of lycopene treatment significantly attenuated oxidative damage, demonstrating their anti-oxidant like effect. It has been reported that lycopene, the most effective antioxidant among the carotenoids, is highly efficient scavenger of 1 O 2 (Aydin et al, 2013). Lycopene with eleven conjugated and two non-conjugated double bonds is the most efficient singlet oxygen quencher among all the natural carotenoids.…”

Section: Discussionmentioning

confidence: 99%

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

Prakash

Kumar

2014

European Journal of Pharmacology

103

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Section: Discussionmentioning

confidence: 99%

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

Prakash

Kumar

2014

European Journal of Pharmacology

103

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“…38 The enhanced production of liver lipid peroxides observed in our study is in agreement with other studies. 8 Lycopene may protect against the in vivo oxidation of lipids and proteins. 39 The data show that oral coadministration of lycopene decreased the MDA, 4HNE, and PCC levels although their values still were more than that of the baseline.…”

Section: Discussionmentioning

confidence: 99%

“…Lycopene is an antioxidant found in tomato, tomato products, and in other red fruits and vegetables. 8 The known protective effect of tomatoes against some types of pathologies mediated by oxidative processes has been attributed to lycopene. 9 It is the pigment principally responsible for the characteristic deep red color of ripe tomato fruits and tomato products and has attracted attention because of its biological and physicochemical properties, especially related to its effects as a natural antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Lycopene attenuates dichlorvos-induced oxidative damage and hepatotoxicity in rats

El-Saad

Ibrahim

et al. 2015

Hum Exp Toxicol

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Because of the widespread use of dichlorvos (DDVP) for domestic applications, evaluation of their toxic effects is of major concern to public health. Lycopene may lower oxidative stress by a mechanism that is not fully elucidated. The present study was undertaken to evaluate the protective efficacy of lycopene in terms of normalization of altered biochemical parameters following DDVP treatment in rats. Animals were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were orally treated with lycopene (10 mg kg−1 body weight (b.w.)), DDVP (1.6 mg kg−1 b.w.), and DDVP plus lycopene, respectively. Results showed that oral administration of DDVP for 30 days increased the levels of lipid peroxidation markers such as malondialdehyde, 4-hydroxynonanal, and protein carbonyl content in liver. Also, a decrease in levels of vitamin C, vitamin E, and reduced glutathione was detected due to DDVP administration. These were accompanied by a decrease in the activities of antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione- S-transferase in the liver tissue. Moreover, DDVP increased the activities of serum transaminases, alkaline phosphatase, lactate dehydrogenase, and lipoxygenase, and the levels of bilirubin, total cholesterol, low-density lipoprotein cholesterol, triglyceride and DNA–protein crosslinks, and 8-hydroxy-2-deoxyguanosine, while decreased the level of high-density lipoprotein cholesterol. Our results provide new insights into the biochemical studies of relation between DDVP hepatotoxicity and lycopene treatment. Administration of lycopene to DDVP-treated rats reverted the status of hepatic markers to near-normal levels. These data suggest that lycopene can protect against the liver damage induced by DDVP.

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“…Chronic liver disease is an important cause of morbidity and mortality and represents a major health problem worldwide [45].The high prevalence of chronic liver diseases in Egypt has led to increasing numbers of Egyptian patients suffering from end-stage liver disease [46]. Obstructive jaun¬dice, a frequently observed condition caused by obstruction of the common bile duct or its flow may end up with serious complications like hepatic failures [47]. Cholestatic liver fibrosis, characterized by excessive accumulation of extracellular matrix (ECM) proteins [48].…”

Section: Antifibrotic Effects Of H Arenicolamentioning

confidence: 99%

Holothuria Arenicola as Promising Material for Therapeutic Drugs

Fahmy¹

2018

SOJPPS

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Marine invertebrates have become attractive as nutraceutical and functional foods and as a source material for the development of therapeutic drugs. The bioactivity of echinoderm, Holothuria arenicola extracts and their secondary metabolites has been identified by researchers as a promising potential rich source of natural drugs. H. arenicola is rich in several phenolic compounds, amino acids, alkaloids and other important nutraceutical compounds. H. arenicola extract has been shown to produce promising antiulcerogenic efficacy that attributed to its high content of chlorogenic acid. The health benefits of H. arenicola are associated with its antioxidant, antifibrotic and antimicrobial effects. H. arenicola extract induced an apparent arrest in the progression of collagen deposition in the cholestatic animals which may be a consequence of the increased mass of regenerated liver cells. The previous work showed that the antibacerial efficacy of H. arenicola body wall extract may be due to its content of polyphenolic compound especially quinine, saponins and terpenoid. Thus, this review aims to elaborates and analyze the role of H. arenicola in the modulation of several organ-specific diseases.

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Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice

Cited by 27 publications

References 68 publications

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

Lycopene attenuates dichlorvos-induced oxidative damage and hepatotoxicity in rats

Holothuria Arenicola as Promising Material for Therapeutic Drugs

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