Antioxidant, Analgesic and Toxic Potentiality of Stephania Japonica (Thunb.) Miers. Leaf

Rahman, Habibur; Alam, Md. Shahin; Chowdhury, Nargis Sultana; Jha, Mithilesh Kumar; Hasan, Mizaton Hazizul; Khan, Maruf; Rahman, Md. Saifur; Haque, Ekramul

doi:10.3923/ijp.2011.257.262

Cited by 31 publications

(20 citation statements)

References 4 publications

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“…[31][32] The bulk density of the blend was found between 0.58g/cm 3 to 0.68 g/cm 3 .Tapped density was found between 0.68g/cm 3 to 0.76 g/cm 3 .These values indicate that the blends had good flow property. Carr's index for all the formulations was found to be between 10.21-14.63…”

Section: Stability Studiessupporting

confidence: 50%

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Ganesh¹

2017

WJPPS

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The main aim of the proposed work was to develop Tramadol matrix tablets, sustained release dosage form. Tramadol is a narcotic analgesic proposed for moderate to severe pain Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release tablets were prepared by direct compression method using Hydroxypropyl methyl cellulose as a K100M grade, Karayagum and Guar gum in varying ratios. Tablets blends were evaluated for Bulk density, Tapped density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these

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Section: Stability Studiessupporting

confidence: 50%

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Ganesh¹

2017

WJPPS

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“…Leaves and roots are bitter and astringent; used in fever, diarrhoea, urinary diseases and dyspepsia. Different studies have shown that a crude methanolic extract exhibited good analgesic activity, vital cytotoxic activity and moderate antioxidant activity [18]. Study of Stephania japonica roots showed diuretic activity [19].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antihyperlipidemic Activities of Methanolic Leaf Extract of <i>Stephania japonica</i> in Alloxan Induced Diabetic Rats

Zehad¹,

Islam²,

Rashid³

et al. 2017

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This present study was aimed to investigate the antidiabetic and antihyperlipidemic activities of methanolic leaf extract (LE) of Stephania japonica alone and in combination with metformin in alloxan induced diabetic rats. Primarily acute toxicity study and oral glucose tolerance test were performed. Diabetes was confirmed after 12 days of single intraperitoneal injection of alloxan (120 mg/kg BW) in albino male rats. Rats were divided into six groups'; normal control (Group I) and diabetic induced groups as (Group II, effect and hence could be suggested as a potential therapeutic agent for diabetic treatment.

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“…Docking poses were studied using the CLC drug designing workbench 3 tool. The Schiff bases were carried for experimental antibacterial activity against E. coli [25] pathogen and Brine Shrimp [26,27] toxicity study for the serially diluted solutions. Finally, the computational outcomes were compared with experimental results.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Quantitative Structure-Activity Relationship, Docking, Antibacterial Activity, and Brine Shrimp Lethal Studies on L-Phenylalanine Schiff Bases

Deivanayagam¹,

Jayaprakash²,

Sha³

et al. 2016

Asian J Pharm Clin Res

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Objective: Aim of this work is to synthesize and characterization of the hydroxyl group the hydroxyl group substituted L-phenylalanine Schiff bases to compare their predicted quantitative structure-activity relationship (QSAR) and molecular docking against Escherichia coli protein ZipA (1s1j) outcomes with the antibacterial activity and brine shrimp lethal assay (BSLA) results. Methods:The Schiff bases of L-Phenylalanine were synthesized by the simple condensation reaction using methanol, water in 2:1 ratio at reflux and were characterized by spectral techniques. QSAR parameters of the Schiff bases were predicted using java-based online and offline tools. Molecular docking carried through online mcule server and CLC Drug Discovery Workbench 3. Antibacterial activity and toxicity studies were conducted using broth dilution and brine shrimp lethal assay methods, respectively. Results:The Schiff bases fulfilled the QSAR drug-likeness parameters and showed the docking score between −6.8 and −6.0 Kcal/mol which are higher than amoxilicillin and gentamicin like standard drugs. They also possess good inhibition for urinary tract infection causing E. coli bacteria, and minimum inhibitory concentrations (MIC) exists between 3.25 and 5.25 µg/ml. The brine shrimp lethal concentration for 50% mortality [LC 50 ]) between 58.73 and 135.6 µg/ml. Conclusion:Para, meta and 2,4 hydroxyl substituted Schiff bases exhibited good inhibition against Gram-negative E. coli bacteria at low concentration and the MIC exists below the LC 50 value. The Schiff base showed high drug score, high docking score, and low toxicity than other Schiff base. Docking score, high inhibition, low clogP, low MIC

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Antioxidant, Analgesic and Toxic Potentiality of Stephania Japonica (Thunb.) Miers. Leaf

Cited by 31 publications

References 4 publications

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Antidiabetic and Antihyperlipidemic Activities of Methanolic Leaf Extract of <i>Stephania japonica</i> in Alloxan Induced Diabetic Rats

Synthesis, Characterization, Quantitative Structure-Activity Relationship, Docking, Antibacterial Activity, and Brine Shrimp Lethal Studies on L-Phenylalanine Schiff Bases

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Antioxidant, Analgesic and Toxic Potentiality of Stephania Japonica (Thunb.) Miers. Leaf

Cited by 31 publications

References 4 publications

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Antidiabetic and Antihyperlipidemic Activities of Methanolic Leaf Extract of &lt;i&gt;Stephania japonica&lt;/i&gt; in Alloxan Induced Diabetic Rats

Synthesis, Characterization, Quantitative Structure-Activity Relationship, Docking, Antibacterial Activity, and Brine Shrimp Lethal Studies on L-Phenylalanine Schiff Bases

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Antidiabetic and Antihyperlipidemic Activities of Methanolic Leaf Extract of <i>Stephania japonica</i> in Alloxan Induced Diabetic Rats