Antioxidant Activity of Ilex Paraguariensis and Related Species

Filip, R

doi:10.1016/s0271-5317(00)00227-x

Cited by 57 publications

(95 citation statements)

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“…Mate is used for its central nervous system stimulant properties, which are due to the presence of the methylxanthines caffeine and theobromine (Blumenthal and Brinckmann, 2000;Dermarderosian, 2001;Filip et al, 1998). Additionally, yerba-mate is also considered a functional food, because of its nutritional and medicinal properties, such as hypocholesterolemic, hepatoprotective, diuretic, and antioxidant properties (Bixby et al, 2005;Filip et al, 2000;Gugliucci and Stahl, 1995;Heck and De Mejia, 2007;Rivelli et al, 2007;Valerga et al, 2012), which can protect against the harmful effect of free radicals, thereby increasing the defense system of the organism. It can also help prevent atherosclerosis and coronary heart disease (Heck and De Mejia, 2007;Miranda et al, 2008;Puangpraphant and de Mejia, 2009).…”

Section: Introductionmentioning

confidence: 99%

The influence of leaf age on methylxanthines, total phenolic content, and free radical scavenging capacity of Ilex paraguariensis aqueous extracts

Blum-Silva

Chaves

Schenkel

et al. 2015

Revista Brasileira de Farmacognosia

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Please cite this article in press as: Blum-Silva, C.H., et al. The influence of leaf age on methylxanthines, total phenolic content, and free radical scavenging capacity of Ilex paraguariensis aqueous extracts. Revista Brasileira de Farmacognosia (2015), http://dx.BJP 84 1-6 Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a Original Article a b s t r a c tYerba-mate (Ilex paraguariensis A. St. Hil., Aquifoliaceae) is a South American native species that is widely used for its industrial potential in the preparation of drinks, teas and cosmetics. Its properties are directly related to the presence of its chemical constituents, such as saponins, methylxanthines and phenolic compounds. This study aimed to investigate the influence of leaf age on methylxanthine and total phenolic contents by High Performance Liquid Chromatography and UV, as well as on free radical scavenging Q2 capacity by UV, of aqueous extracts of I. paraguariensis leaves. The results showed great variability in all the metabolites measured. Leaf ageing significantly increased the methylxanthine content and total phenolic content of the extracts. Free radical scavenging capacity was also significantly affected (p < 0.05) by leaf age. A positive correlation was observed, between the antioxidant activity and total phenolic content. Q3

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Section: Introductionmentioning

confidence: 99%

The influence of leaf age on methylxanthines, total phenolic content, and free radical scavenging capacity of Ilex paraguariensis aqueous extracts

Blum-Silva

Chaves

Schenkel

et al. 2015

Revista Brasileira de Farmacognosia

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“…Although data on polyphenol bioavailability and its metabolic fate are scarce and controversial (Karakaya, 2004), many studies involving humans have provided evidence that these compounds undergo absorption and urinary excretion after the intake of phenolic-rich foods (Pedersen et al, 2000;Rechner, Spencer, Kuhnle, Hahn, & Rice-Evans, 2001). Beverages made from yerba mate are also recognised as a source of antioxidant substances, such as phenolic acids (Filip, Lotito, Ferraro, & Fraga, 2000), which are readily absorbed by the body (Bravo, 1998;Olthof, Hollman, Buijsman, van Amelsvoort, & Katan, 2003).…”

Section: Introductionmentioning

confidence: 99%

Study of the bioactive compounds variation during yerba mate (Ilex paraguariensis) processing

et al. 2010

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“…Previous phytochemical investigations on this plant have shown the presence of many bioactive compounds such as xanthines, caffeoyl derivatives, flavonoids and triterpenoid saponins Saldana et al, 2002;Alikaridis et al, 1987;Ohem and Holzl, 1981;Gosmann et al, 1995). Various biological activities of Yerba Mate have been reported, such as antioxidant & cellular protective actions (Filip et al, 2000;Gugliucci and Stahl, 1995), anti-obesity & thermogenic actions (Martinet et al, 1999), circulatory system action and hypocholesterolemic effect (Gorgen et al, 2005), and bile stimulant actions (Gorzalczany et al, 2001). However, its effect on HNE is unclear.…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents from the leaves of Ilex paraguariensis inhibit human neutrophil elastase

Kim

Choo

et al. 2009

Arch. Pharm. Res.

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Human neutrophil elastase (HNE), a serine protease with broad target specificity, is the only enzyme responsible for the degradation of elastin which is an insoluble elastic fibrous protein in animal connective tissue. Biologically, elastase activity significantly increased with age, which results in a reduced skin elasticity and in the appearance of wrinkles or stretchmarks. In the course of our screening program for HNE inhibitors from natural source, the MeOH extract of Ilex paraguariensis leaves showed strong HNE inhibitory effect. Bioassay-guided fractionation led to the isolation of a new pyrrole alkaloid (1), along with seventeen known compounds (2-18) from the MeOH extract of Ilex paraguariensis leaves, and their chemical structures were elucidated on the basis of spectroscopic analysis. All isolated compounds were evaluated for HNE inhibitory activity, and the result demonstrated that dicaffeoylquinic acid derivatives (12, 13, 14, 15 and 16) and flavonoids (8 and 17) exhibited potent HNE inhibitory activity with IC50 values ranging from 1.4 to 7.3 microM.

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Antioxidant Activity of Ilex Paraguariensis and Related Species

Cited by 57 publications

References 0 publications

The influence of leaf age on methylxanthines, total phenolic content, and free radical scavenging capacity of Ilex paraguariensis aqueous extracts

The influence of leaf age on methylxanthines, total phenolic content, and free radical scavenging capacity of Ilex paraguariensis aqueous extracts

Study of the bioactive compounds variation during yerba mate (Ilex paraguariensis) processing

Chemical constituents from the leaves of Ilex paraguariensis inhibit human neutrophil elastase

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