Antioxidant Activity of Bisabolol: Inhibitory Effects on Chemiluminescence of Human Neutrophil Bursts and Cell-Free Systems

Braga, Pier Carlo; Sasso, M. Dal; Fonti, E.; Culici, M.

doi:10.1159/000186049

Cited by 72 publications

(40 citation statements)

References 52 publications

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“…Other findings in the literature suggest that (−)-α-bisabolol has marked anti-inflammatory action; however, these works used plants containing (−)-α-bisabolol (Moreno-Fernandes et al 1992;Braga et al 2009). There are no studies of the isolated drug in traditional models of inflammation and pain.…”

Section: Introductionmentioning

confidence: 99%

Anti-nociceptive and anti-inflammatory activities of (−)-α-bisabolol in rodents

Rocha

Rios

Carvalho

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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(-)-α-Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation of essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla. (-)-α-Bisabolol has generated considerable economic interest, as it possesses a delicate floral odour and has been shown to have antiseptic and gastroprotective activities. In this study, (-)-α-bisabolol was tested in standardised rodent models by gavage administration at doses of 100 and 200 mg/kg in the models of inflammation and 25 and 50 mg/kg in the models of nociception. In the inflammatory models of paw oedema induced by carrageenan and dextran, the mice treated with (-)-α-bisabolol showed smaller oedemas compared to animals treated only with the vehicle. (-)-α-Bisabolol was capable of reducing paw oedemas induced by 5-HT but not oedemas induced by histamine. (-)-α-Bisabolol demonstrated anti-nociceptive activity in the models of visceral nociception induced by acetic acid and in the second phase of the nociception test induced by the intraplantar administration of formalin. (-)-α-Bisabolol did not have any effect in a thermal nociception model using a hot plate but was able to diminish mechanical inflammatory hypernociception evoked by carrageenan. These findings suggest that the anti-nociceptive action of (-)-α-bisabolol is not linked to a central mechanism but instead is related to the inflammatory process. (-)-α-Bisabolol was able to decrease leukocyte migration, protein extravasations and the amount of TNF-α to the peritoneal cavity in response to carrageenan. Additionally, (-)-α-bisabolol reduced neutrophil degranulation in response to phorbol-myristate-acetate. We demonstrate, for the first time, the peripheral anti-inflammatory and anti-nociceptive activities of (-)-α-bisabolol.

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Section: Introductionmentioning

confidence: 99%

Anti-nociceptive and anti-inflammatory activities of (−)-α-bisabolol in rodents

Rocha

Rios

Carvalho

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Recent studies demonstrated that the sesquiterpene α-bisabolol (BISA) presents antitumor [6], peripheral nervous blocker [7], gastroprotective [8], leishimanicidal [9], antioxidant [10], mutagenic and antimutagenic [11], and wound healing [12] properties. There are also evidences showing that BISA reduced visceral nociceptive pain evoked by intracolonic administration of mustard oil (MO) as well as that induced by intraperitoneal injection of cyclophosphamide, possibly involving the inhibition of sensitization of primary afferent neuron terminals by prostaglandins [13].…”

Section: Introductionmentioning

confidence: 99%

Attenuation of visceral nociception by α-bisabolol in mice: investigation of mechanisms

et al. 2012

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BackgroundWe previously described the visceral antinociceptive property of α-bisabolol (BISA) in mouse models of visceral nociception induced by cyclophosphamide and mustard oil (MO). This study examined the effect of BISA in mouse models of visceral nociception induced by acetic acid, capsaicin, formalin, and the contribution of the nitric oxide system, α2, KATP, 5-HT3 and TRPV1 receptors to the effect of BISA on MO-evoked nociceptive behaviors. Mice were pretreated orally with BISA (50, 100 and 200 mg/kg) or vehicle, and the pain-related behavioral responses to intraperitoneal administration of acetic acid or intracolonic injection of MO were analyzed.ResultsBISA significantly suppressed the nociceptive behaviors in a dose-unrelated manner. The antinociceptive effect of BISA (50 mg/kg) was show to be glibenclamide resistant, but it was not blocked by pretreatment with the other antagonists tested. In the open-field test that detects sedative or motor abnormality, mice received 50 mg/kg BISA did not show any per se influence in ambulation frequency.ConclusionsHowever, their precise antinociceptive mechanisms of action have not been determined.

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“…The anti-inflammatory effects of azulenes may be related to an influence on the pituitary and adrenal glands, through increased cortisone release and reduced histamine production (Rekka et al, 1996). In cell culture studies, both bisabolol and bisabolol oxide have been shown to inhibit 5-lipoxygenase activity (Braga et al, 2009). Apigenin 7- O -glucoside application has been shown to inhibit skin inflammation caused by application of xanthine-oxidase and cumene hydroperoxide in rats (Fuchs and Milbradt, 1993).…”

Section: Introductionmentioning

confidence: 99%

Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity

2009

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Aims Inducible cyclooxygenase (COX-2) has been implicated in the process of inflammation and carcinogenesis. Chamomile has long been used in traditional medicine for the treatment of inflammatory diseases. In this study we aimed to investigate whether chamomile interferes with the COX-2 pathway. Main Methods We used lipopolysaccharide (LPS)-activated RAW 264.7 macrophages as an in vitro model for our studies. Key Findings Chamomile treatment inhibited the release of LPS-induced prostaglandin E(2) in RAW 264.7 macrophages. This effect was found to be due to inhibition of COX-2 enzyme activity by chamomile. In addition, chamomile caused reduction in LPS-induced COX-2 mRNA and protein expression, without affecting COX-1 expression. The non-steroidal anti-inflammatory drug, sulindac and a specific COX-2 inhibitor, NS398, were shown to act similarly in LPS-activated RAW 264.7 cells. Our data suggest that chamomile works by a mechanism of action similar to that attributed to non-steroidal anti-inflammatory drugs. Significance These findings add a novel aspect to the biological profile of chamomile which might be important for understanding the usefulness of aqueous chamomile extract in the form of tea in preventing inflammation and cancer.

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Antioxidant Activity of Bisabolol: Inhibitory Effects on Chemiluminescence of Human Neutrophil Bursts and Cell-Free Systems

Cited by 72 publications

References 52 publications

Anti-nociceptive and anti-inflammatory activities of (−)-α-bisabolol in rodents

Anti-nociceptive and anti-inflammatory activities of (−)-α-bisabolol in rodents

Attenuation of visceral nociception by α-bisabolol in mice: investigation of mechanisms

Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity

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