Antioxidant activity of Artocarpus altilis (Parkinson) Fosberg leaves

Sikarwar, Mukesh S.; Hui, Boey Jia; Subramaniam, Kumutha; Valeisamy, Bavani Devi; Yean, Ling Kar; Balaji, Kaveti

doi:10.5530/fra.2014.2.7

Cited by 29 publications

(35 citation statements)

References 10 publications

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“…3. Inhibiting proliferation via the activation of caspase-3 and caspase-9, up-regulation of the ratio of bax/bcl-2 protein expression in Ardisia brevicaulis [61] Artocarpus obtusus [50,62] Ardisia brecaulis [63], Carica papaya [64] Catharanthus roseus [118][119], Costus speciosus [121][122], Cucuma zedoaria [65], Dysoxylum cauliforum [66], Goniosthalamus macrophyllus [137][138], Gynura procumbens [139], Lawsonia inermis [56,[146][147], Leea indica [148][149], Nepthelium lappaceum [56,156] Pandanus amarylfolius [41], Phyla nodiflora [67], Physalis minima [52,78], Rhodiola rosea [68], Vernonia amygdalina [65] and Schima wallichi [38]. 4.…”

Section: Resultsmentioning

confidence: 99%

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

Mainasara

Bakar

Linatoc

2018

Asian J Pharm Clin Res

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Objective: This review focused on Malaysian medicinal plants that have been evaluated and pose potentials to treat breast cancer. Results: A total of 105 plants species representing 54 different families and 79 genera were reviewed. 97% of the plants were tested using MCF-7 and MDA-231 breast cancer cell lines and exhibited most significant in vitro anticancer activity, and 3% were tested using another type of breast cancer cell lines. Most of the bioactive compounds of the medicinal plants that exhibited good activity (IC 50 values <120 µg/mL) are a group of phenols, alkaloids, flavonoids, terpenoids, and saponins. Induction of apoptosis was found to be the significant cell death pathway. Methods Conclusion:This article reviews the available literature concerning research on anti-breast cancer plants. Furthermore, identification and characterization of active components and toxicology evaluation also need to be studied in details and also point out their clinical trials.

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Section: Resultsmentioning

confidence: 99%

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

Mainasara

Bakar

Linatoc

2018

Asian J Pharm Clin Res

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“…Penyebaran tanaman sukun di Indonesia sangat luas mulai dari Aceh sampai Papua (Rukmana 2007). Sukun sangat cocok tumbuh di daerah panas dan beriklim tropis (Sikarwar et al 2014). Sukun tergolong mudah dibudidayakan secara berkelanjutan dengan sedikit input pertanian (Jones et al 2011).…”

Section: Pendahuluanunclassified

The Diversity of Breadfruit Plants (Artocarpus Altilis) Based on Morphological Characters

2018

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<p>Breadfruit (Artocarpus altilis) is a plant common are all part of it can be used by humans. The research aims to determine the character of morphological breadfruit and knowing the characterization of morphological breadfruit in Yogyakarta. This research was carried out in June to October 2017 in Sleman Regency (Cangkringan, Ngemplak, Ngaglik), Gunung Kidul (Patuk, Nglipar, Gedangsari), and Bantul (Bantul, Pajangan, Imogiri) in Yogyakarta. Variables are observations include the environmental research and morphology of (trees, leaves, fl owers, and fruits). The data of the morphology are analyzed by NTSYS program. The results showed that the breadfruit trees has a plant height 16,7-17,9 m, the diameter of crown 6,1-8,8 m, shape of crown of the pyramidal, broadly pyramidal, elliptical, irregular, the patterns of branching of erect, opposite, and irregular. The length of leaf 42,2-78,6 cm, width of leaf 30,2-59,2 cm, shape of leaf ovate, and leaf colour dark green. The length of male flowers 9,0-13,4 cm, shape of female flowers globose, shape of male flowers ellipsoid, the colour of female flowers light green, the colour of male flowers light green when young, and brown when old. The length of fruit 12,2 -19,0 cm,diameter of fruit 12,8-16,4 cm, weight of fruit 0,7-1,7 kg, shape of fruit sperical and oblong, fruit skin colour greenish yellow, fruit flesh colour white and light yellow. The diversity of morphology of the breadfruit plants ranging from 3-30%.</p>

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“…It includes mainly jackfruit ( Artocarpus integrifolia ) and breadfruit ( Artocarpus altilis , also known as Artocarpus incisa ) trees, which are restricted to evergreen forests in the humid tropical zone [1,2]. The genus is also widely used in folk medicines, prompting scientific interest in secondary metabolites possessing useful biological activities.…”

Section: Introductionmentioning

confidence: 99%

Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights

et al. 2017

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Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discovery as already reported. FTP is the second most abundant, but proved difficult to purify with very low yields and contamination with Frutalin frustrating its characterization. Here, we report for the first time high-level production and isolation of biologically active recombinant FTP in Escherichia coli BL21, optimizing conditions with the best set yielding >40 mg/l culture of soluble active FTP. The minimal concentration for agglutination of red blood cells was 62.5 µg/ml of FTP, a process effectively inhibited by mannose. Apo-FTP, FTP–mannose and FTP–glucose crystals were obtained, and they diffracted X-rays to a resolution of 1.58 (P212121), 1.70 (P3121) and 1.60 (P3121) Å respectively. The best solution showed four monomers per asymmetric unit. Molecular dynamics (MD) simulation suggested that FTP displays higher affinity for mannose than glucose. Cell studies revealed that FTP was non-cytotoxic to cultured mouse fibroblast 3T3 cells below 0.5 mg/ml and was also capable of stimulating cell migration at 50 µg/ml. In conclusion, our optimized expression system allowed high amounts of correctly folded soluble FTP to be isolated. This recombinant bioactive lectin will now be tested in future studies for therapeutic potential; for example in wound healing and tissue regeneration.

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Antioxidant activity of Artocarpus altilis (Parkinson) Fosberg leaves

Cited by 29 publications

References 10 publications

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

The Diversity of Breadfruit Plants (Artocarpus Altilis) Based on Morphological Characters

Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights

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