Antioxidant Activity and α-Glucosidase Inhibitory Effect of Jerusalem Artichoke (Helianthus tuberosus) Methanol Extracts by Heat Treatment Conditions

Jeong, Hyeon-Ju; Kim, Ju-Sung; Sa, Yeo-Jin; Kim, Myeong-Ok; Yang, Jinfeng; Kim, Myong Jo

doi:10.7783/kjmcs.2011.19.4.257

Cited by 14 publications

(4 citation statements)

References 12 publications

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“…1, PM and PMH extracts inhibited α-glucosidase activity in a dose-dependent manner, with PMH which contained H. tuberosus power having a higher inhibitory effect than PM. It has been reported that the extract H. tuberosus exhibited powerful inhibitory efficacy against α-glucosidase activity [30]. This result might be basic data for development of anti-diabetic functional therapeutic product using H. tuberosus.…”

Section: Effects Of Pm and Pmh Extracts On In Vitro α-Glucosidase Act...mentioning

confidence: 76%

Ethanolic Extract of Pancake Mixture Powder Supplemented with Helianthus tuberosus Enhances Antidiabetic Effects via Inhibiting Inflammatory Mediator NO Production

Lee¹,

Sun

Lee

et al. 2022

Microbiol. Biotechnol. Lett.

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Helianthus tuberosus is perennial plant as Compositae family and is shown various physiological activities such as analgesic, antipyretic, anti-inflammatory, anti-fungal, anti-spasmodic, aperient, cholagogue, diuretic, spermatogenic, stomachic, and tonic effects. In this study, we investigated the antidiabetic and anti-inflammatory effects of pancake mixture powder (PM) supplemented with H. tuberosus (PMH) in rat skeletal muscle L6 cells and murine macrophage RAW 264.7 cells, respectively. PM and PMH inhibited in vitro α-glucosidase activity. Glucose consumption was increased by PM and PMH without cytotoxicity in rat myoblast L6 cells. Western blot analysis revealed that PM and PMH down-regulated glycogen synthase kinase (GSK)-3β activation in L6 cells. PM and PMH inhibited inflammatory mediator, nitric oxide (NO) production without cytotoxicity in LPS-induced RAW 264.7 cells. The anti-diabetic and anti-inflammatory effects of PMH was more stronger than those of PM. Anti-diabetic and anti-inflammatory effects of PMH would be due to functional characteristics of the supplemented H. tuberosus and the presence of garlic and onion used as ingredients of PM. Taken together, our results that addition of functional materials such as H. tuberosus in product has synergic effects and PMH is potential candidate for treatment of diabetes through inhibiting inflammation.

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Section: Effects Of Pm and Pmh Extracts On In Vitro α-Glucosidase Act...mentioning

confidence: 76%

Ethanolic Extract of Pancake Mixture Powder Supplemented with Helianthus tuberosus Enhances Antidiabetic Effects via Inhibiting Inflammatory Mediator NO Production

Lee¹,

Sun

Lee

et al. 2022

Microbiol. Biotechnol. Lett.

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“…Preheating treatment of the JA tubers inhibited the browning reaction enzymes that hindered the development of color pigments during the process of extracting JA juice. The preheating treatment of JA tubers also helps in maintaining the color during JA juice production (Bach et al., 2013; Jeong et al., 2011; Kim et al., 2010). Additionally, the JA tubers were subjected to the preheating treatment to obtain a healthy and flavorful drink, preserving distinctive freshness as well as better sensory properties.…”

Section: Resultsmentioning

confidence: 99%

Assessing synergistic effect of Jerusalem Artichoke juice and antioxidant compounds on enhanced viability and persistence ofBifidobacteriumspecies, palatability, and shelf life

Alsharafani

Abdullah

Jabur

et al. 2022

Food Science & Nutrition

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Commercial vegetable and fruit juices with probiotics are new functional type of beverages; however, limitations including persistence and impact of probiotic bacteria on palatability and shelf life may prevent their industrial development. This study evaluated the effect of antioxidant compounds (ascorbic acid, astaxanthin, and ginseng) on viability and persistence of Bifidobacterium spp. in Jerusalem Artichoke (JA) juice; and determine the impact of these antioxidants on the sensory (color, texture, flavor, acidity) properties, free reducing sugar (inulin and fructose), and shelf life in the fortified JA juice. Overall, the JA juice fortified with ascorbic acid showed a significant impact on the rate of persistence of two targeted bifidobacterial strains from 1 to 28 days at 5°C. Both strains produced slight acidity in ascorbic acid fortified JA juice as compared to other tested samples. Similarly, the JA juice fortified with ascorbic acid showed a significantly high increase in the total number of bifidobacterial cells of both species, enhanced palatability, and shelf life as compared to astaxanthin and ginseng extract. The quadratic model indicated a strong association between ascorbic acid, ginseng extract, and astaxanthin with a bifidobacterial cell concentration in the fortified JA juices. The Box-Behnken design was considered a feasible analysis for describing fortified JA juice and the rate of viability and persistence of bifidobacteria during 28 days of storage at 5°C in all trials. In conclusion, JA juice fortified with ascorbic acid showed a significant impact on improving the cell viability and persistence of probiotic bacteria, enhanced palatability, and shelf life as compared to other compounds tested.

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“…Therefore, alpha-glucosidase inhibition reduces the rate of glucose absorption by delaying carbohydrate digestion and reduces postprandial glycemia independently of insulin ( 22 ). According to the results of previous studies, the tubers, flowers, and leaves of Jerusalem artichoke inhibit alpha-glucosidase and have an antioxidant effect ( 23 – 25 ), but the mechanism is not fully understood. However, these effects of Jerusalem artichoke are likely to be, at least in part, mediated by caffeoylquinic acids ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans

Takahashi

Nakajima

Matsumoto

et al. 2022

Food & Nutrition Research

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Background: The consumption of Jerusalem artichoke has multiple beneficial effects against diabetes and obesity. Objective: The aim of this study was to determine the effect of a single administration of Jerusalem artichoke tubers on postprandial glycemia and the concentrations of incretin hormones in humans. Method: Grated Jerusalem artichoke was administered prior to a meal (Trial 1; white rice for prediabetic participants, n = 10). Dose-dependent effect of Jerusalem artichoke (Trial 2; white rice for prediabetic participants, n = 4) and effect prior to the fat-rich meal were also investigated (Trial 3; healthy participants, n = 5) in this pilot study. Circulating glucose, insulin, triglyceride, glucagon, active glucagon-like peptide-1 (GLP-1), and active glucose-dependent insulinotropic polypeptide (GIP) concentrations were subsequently measured in all the trials. Results: Jerusalem artichoke significantly reduced the glucose and GIP concentrations after the consumption of either meal in Trial 1 and Trial 3, whereas there were no differences in the insulin, glucagon, and active GLP-1 concentrations. Also, there was no significant difference in the triglyceride concentration after the ingestion of the fat-rich meal in Trial 3. The glucose and GIP-lowering effects were dose-dependent, and the consumption of at least 100 g of Jerusalem artichoke was required to have these effects in Trial 2. Conclusion: This study demonstrates that a single administration of Jerusalem artichoke tubers reduces postprandial glucose and active GIP concentrations in prediabetic and healthy individuals.

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Antioxidant Activity and α-Glucosidase Inhibitory Effect of Jerusalem Artichoke (Helianthus tuberosus) Methanol Extracts by Heat Treatment Conditions

Cited by 14 publications

References 12 publications

Ethanolic Extract of Pancake Mixture Powder Supplemented with Helianthus tuberosus Enhances Antidiabetic Effects via Inhibiting Inflammatory Mediator NO Production

Ethanolic Extract of Pancake Mixture Powder Supplemented with Helianthus tuberosus Enhances Antidiabetic Effects via Inhibiting Inflammatory Mediator NO Production

Assessing synergistic effect of Jerusalem Artichoke juice and antioxidant compounds on enhanced viability and persistence ofBifidobacteriumspecies, palatability, and shelf life

Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans

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