Antioxidant activity and antiapoptotic effect of Asparagus racemosus root extracts in human lung epithelial H460 cells

Kongkaneramit, Lalana; Witoonsaridsilp, Wasu; Peungvicha, Penchom; Ingkaninan, Kornkanok; Waranuch, Neti; Sarisuta, Narong

doi:10.3892/etm.2010.172

Cited by 20 publications

(16 citation statements)

References 25 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study showed that the scavenging ability, total phenolic compounds and total flavonoid contents of the ethanolic extract were higher than those from the aqueous extract but were four times lower than those reported from a methanolic extract. 2 The scavenging ability of the aqueous extract in this study was better than the study of Kongkaneramit et al 1 The previous study reported that the main components were saponins such as shatvarin, sarsapogenin and kaempferol. The presence of phenolic compounds is shown mostly via the antioxidant activities of plant sources.…”

Section: Discussioncontrasting

confidence: 60%

Antioxidant Activities of Ethanolic and Aqueous Extracts of Asparagus racemosus Roots

Taepongsorat¹,

Rattana²

2018

View full text Add to dashboard Cite

Asparagus racemosus (AR) wild., (Family: Liliaceae), commonly known as shatavari, satawar or satmuli, is found in all over India, and is commonly known in Thailand as sam-sib or rak-sam-sib. In Ayurveda, the dried root of AR is used as a tonic, galactogogue, aphrodisiac, rejuvenator, antispasmodic, antiulcerous and anti-inflammatory agent. Steroidal saponins and sapogeninsare the pharmacological value of the AR root. 1-2 Antioxytocic activities, antihepatotoxic, hepatopathy, dyspepsia and dysentery are the uses of the root of AR for treatment. 1 Recent reports on AR indicate that the root extracts show antioxidant and antidiarrheal activities in animal models. 3-4 Phytoanalysis of the AR root composition by Visavadiya et al. 5 found phytosterols 0.79%, saponins 8.83%, polyphenols 1.69%, flavonoids 0.47% and total ascorbic acid 0.76%. AR contains alkaloids, flavonoids, tannins, saponins, phenols, terpenes, polysaccharides and steroids. 5 AR root extract was found to contain flavonoids, polyphenols and vitamin C, which were found to exhibit the greatest antioxidant activity. A phytoestrogenic effect of AR root extracts has recently been found as well as antidiarrhoeal, antidyspepsia, adaptogenic, cardioprotective, antibacterial, immune adjuvant and antitussive effects. The methanolic and aqueous extracts of AR roots have been produced in Antioxidant Activities of Ethanolic and Aqueous Extracts of Asparagus racemosus Roots Background: Asparagus racemosus (AR) is commonly known as shatavari, satawar or satmuli in India and in Thailand it is call sam-sib or rak-sam-sib. The dried root of AR is used in Ayurveda as an antiulcerous and antiinflammatory and has medicinal/pharmacological value. Objective: To investigate the antioxidant activities of Asparagus racemosus root extracts via total phenolic and total flavonoid contents of ethanolic and aqueous extracts. Methods: Antioxidant capacity measurements were carried out by DPPH, ABTS and FRAP methods. Total phenolic and flavonoid contents were determined by the Folin-Ciocalteu method and the aluminum chloride colorimetric method, respectively. Results: The ethanolic extract possessed higher antioxidant capacities than the aqueous extract in the three antioxidant assays (p<0.05).These results have shown high phenolic and flavonoid contents. The ethanolic extract of AR root possessed higher amounts of phenolic and flavonoid contents than the aqueous extract. Conclusion: The antioxidant capacity of the ethanolic extract was higher than that in the aqueous extract. .

show abstract

Section: Discussioncontrasting

confidence: 60%

Antioxidant Activities of Ethanolic and Aqueous Extracts of Asparagus racemosus Roots

Taepongsorat¹,

Rattana²

2018

View full text Add to dashboard Cite

show abstract

“…Comprehensive fractionation of Thai A. racemosus was carried out by Kongkaneramit et al . () resulted in antioxidant activity (determined as DPPH radical scavenging activity and reported as EC 50 ) of aqueous and hydro‐alcoholic fractions that had EC 50 of 500–600 μg mL −1 which was much lower than that found with ascorbic acid (1.5 μg mL −1 ). A 70% methanol A. racemosus extract was fractioned by methanol, ethyl acetate, n‐Butanol, and water‐precipitated materials were examined for their antioxidant activities using DPPH radical scavenging activity (Acharya et al ., ).…”

Section: Phytochemistry Of Armentioning

confidence: 78%

Phytochemical compounds and biological activity in Asparagus roots: a review

Zhang

Birch

Pei

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

Asparagus roots (AR) contain many bioactive compounds and their use in Chinese and Indian traditional medicines is well documented. Both in vitro and in vivo studies have indicated AR extracts act as antidiabetic, antioxidant and hypolipidaemic and depict anti-inflammatory, antibacterial, antiviral, anticarcinogenic activities and also improve cardiovascular and oral health. The physiological effects against wide range of pathologies are due to the wide range of phytochemicals found in AR including polyphenols, saponins and polysaccharides. The aim of this review is to present an overview of the functional, medical and physiological properties of AR bioactives. This review considers the roots of several asparagus species and provides up-to-date information on Asparagus officinalis that has not been extensively reviewed before.

show abstract

“…The extracts of the roots of AR have in the last few years been determined to have a phytoestrogenic effect and help with neurodegenerative disorders, in addition to effects on antidiarrheal, antidyspepsia, adaptogenic, cardioprotective, antibacterial, immunoadjuvant and antitussive. 5 There are two major forms in which the root extracts of AR have been used (methanolic and aqueous extracts) as tablets, powders in tablets or a syrup form. 6 In addition, there have been reports of activities related to immunostimulant, antihepatotoxic or antioxytocic.…”

Section: Introductionmentioning

confidence: 99%

“…6 In addition, there have been reports of activities related to immunostimulant, antihepatotoxic or antioxytocic. 5 In laboratory animals, there have been recent reports the extracts of AR roots have antioxidant and antidiarrheal effects. [7][8] In rats, the lipid peroxidation (malondialdehyde: MDA) decreased while there were increases in superoxide dismutase (SOD), catalase and ascorbic acid by the methanolic root extracts.…”

Section: Introductionmentioning

confidence: 99%

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

Taepongsorat¹,

Phadungkit²

2018

View full text Add to dashboard Cite

Background: Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. Objective: To investigate the effects of Asparagus racemosus (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. Methods: Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. Results: Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. Conclusion: It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances. or sam-roi-rak. The extracts of the roots of AR have in the last few years been determined to have a phytoestrogenic effect and help with neurodegenerative disorders, in addition to effects on antidiarrheal, antidyspepsia, adaptogenic, cardioprotective, antibacterial, immunoadjuvant and antitussive.5 There are two major forms in which the root extracts of AR have been used (methanolic and aqueous extracts) as tablets, powders in tablets or a syrup form. 6 In addition, there have been reports of activities related to immunostimulant, antihepatotoxic or antioxytocic. 5 In laboratory animals, there have been recent reports the extracts of AR roots have antioxidant and antidiarrheal effects. [7][8] In rats, the lipid peroxidation (malondialdehyde: MDA) decreased while there were increases in superoxide dismutase (SOD), catalase and ascorbic acid by the methanolic root extracts.

show abstract

Antioxidant activity and antiapoptotic effect of Asparagus racemosus root extracts in human lung epithelial H460 cells

Cited by 20 publications

References 25 publications

Antioxidant Activities of Ethanolic and Aqueous Extracts of Asparagus racemosus Roots

Antioxidant Activities of Ethanolic and Aqueous Extracts of Asparagus racemosus Roots

Phytochemical compounds and biological activity in Asparagus roots: a review

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

Contact Info

Product

Resources

About