Antioxidant activities of some cameroonian plants extracts used in the treatment of intestinal and infectious diseases

Momeni, Jean; Ntchatchoua, WP Djialeu; Fadimatou,; Akam, M. T; Ngassoum, Martin Benoît

doi:10.4103/0250-474x.62236

Cited by 29 publications

(20 citation statements)

References 14 publications

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“…Previously, the antibacterial activity of leaves extract of Pittosporum viridiflorum against Enterobacter aerogenes, E. coli, Proteus vulgaris, Bacillus cereus, and Salmonella typhi was recorded by Swamy et al [23] The extract was active against all the other organisms except S. typhi, and zones of inhibition were observed to be much similar to the present study. The same results of antioxidant activity of Pittosporum mannii Hook f. were reported by Momeni et al [24] TPC, TFC, and antioxidant potential of Pittosporum dasycaulon Miq. were reported by Mani and Dennis.…”

Section: Antimicrobial Activitysupporting

confidence: 87%

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Semwal¹

2018

IJGP

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Aim: The current study was designed to investigate total phenolic content (TPC), total flavonoid content (TFC), radical scavenging activity and antimicrobial profile of the aqueous, methanolic, ethanolic, and acetone leaf extract of Pittosporum eriocarpum. Materials and Methods: TPC was performed by the Folin-Ciocalteu method and TFC was measured by aluminum chloride assay. The free radical scavenging activity of leaf extracts of P. eriocarpum was ascertained by 1, 1-diphenyl-2-picrylhydrazyl assay and antimicrobial activity were studied by agar well diffusion method and were measured on the basis of the zone of inhibition (ZI) in millimeters. Results and Discussion: Screening of phytochemicals is a basic step in the investigation of the new potent bioactive component before huge extraction. P. eriocarpum leaf extracts possess significant results in terms of TPC and TFC, maximum value of TPC (544.60 ± 28.70 gallic acid equivalent [GAE] mg/g) was recorded in acetone extract while the minimum value of TPC (352.01 ± 32.4 GAE mg/g) was recorded in aqueous extract. The maximum (786.00 ± 13.75 QE mg/g) and minimum (493.30 ± 33.02 QE mg/g) values for TFC were recorded in methanolic and aqueous extracts, respectively. Radical scavenging activity was recorded to be maximum in the methanolic extract (66.91 ± 0.60%), whereas, lowest scavenging activity was recorded for aqueous extract (45.99 ± 0.7%), respectively. P. eriocarpum leaves extracts showed significant antimicrobial potential against three yeast strains (Candida albicans, Candida glabrata, and Candida tropicalis) and three bacterial strains (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa). The maximum ZI was recorded in the methanolic extract (19.03 ± 0.47 mm) against Candida glabrata while minimum ZI 11.53 ± 0.41 mm for C. tropicalis was recorded. Methanolic extract showed maximum ZI of 14.67 ± 00.30 mm against P. aeruginosa while aqueous extract showed minimum ZI of 11.60 ± 00.65 mm for P. aeruginosa, respectively. Fluconazole (for fungal strains), ampicillin (for bacterial strains) and DMSO were used as a positive and negative control. Conclusion: These results may serve as the basic footsteps in the field of biomedical research, and further studies can be directed toward the investigation of novel molecules associated with its antioxidants, phytochemical properties, and antimicrobial properties.

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Section: Antimicrobial Activitysupporting

confidence: 87%

Untitled

Semwal¹

2018

IJGP

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“…ex Schult. It has been reported that phenolics inactivate iron ions by chelating and additionally suppressing the superoxide-driven Fenton reaction, which is believed to be the most important source of reactive oxygen ions [44]. The results from this study suggest that high phenolic content in cultivated A. amatymbica could have pharmacological effects which may also be attributed to agromorphological divergence.…”

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confidence: 59%

Comparative Phytochemical Constituents and Antioxidant Activity of Wild and Cultivated Alepidea amatymbica Eckl & Zeyh

Mangoale

Afolayan

2020

BioMed Research International

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There is a need to scientifically validate the claim that wild species of medicinal plants are more potent than the cultivated plants. Thus, this study evaluated the phytochemical and antioxidant properties of wild and cultivated Alepidea amatymbica. Acetone, methanol, and water extracts of the rhizome of wild and cultivated A. amatymbica were evaluated for total phenol, flavonol, flavonoid, tannin, proanthocyanidin, saponin, and alkaloid contents using spectrophotometric methods. In vitro antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), nitric oxide (NO), and hydrogen peroxide assays. The wild extracts had higher phytochemical contents in most of the assays than cultivated extracts. Total phenol in the wild extracts ranged from 32.30 to 117.8 mg GAE/g with the acetone extracts having the highest content while the water extracts were the least. The range in the total phenol of the cultivated species was 66.46 to 98.44 mg GAE/g with the methanol extracts having the highest content while water extracts was the least. The flavonoid content ranged from 55.01 to 99.09 mg QE/g and from 48.65 to 67.32 mg QE/g for the wild and cultivated plants, respectively. The alkaloid contents ranged from 14.70 to 17.80% in the wild species while it ranged from 11.98 to 13.21% in the cultivated species. The wild species also showed higher antioxidant activities in most of the assays evaluated. This study has implications for both pharmacological and conservation purposes.

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“…Its seeds are also used as food ingredient [16]. R. heudelotii is well documented for some pharmacological properties among which antimicrobial [18, 19] and antioxidant activities [20]. In the continuous search for antibacterial agents from that plant, we have designed this study to investigate the in vitro antibacterial and antibiotic resistance modulating activities of the methanol extracts from leaves and stem bark of R. heudelotii against MDR Gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

Fankam

Kuiaté

Kuete

2017

BMC Complement Altern Med

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Background Recinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the extracts of the leaves (RHL) and bark (RHB) of R. heudelotii for their antibacterial and antibiotic resistance modulating activities against 29 Gram-negative bacteria, including multidrug-resistant (MDR) phenotypes.MethodsThe broth micro-dilution assay was used to evaluate the antibacterial activity, and the antibiotic resistance modulating effects of the plant extracts.ResultsRHL displayed the most important spectrum of activity with minimal inhibitory concentrations (MICs) values ranging from 256 to 1024 μg/mL against 75.86% of the 29 tested bacteria strains while RHB was not active. RHL also showed killing effects with minimal bactericidal concentrations (MBCs) ranging from 256 to 1024 μg/mL. The activities of tetracycline and kanamycin associated with RHL were improved on 88.89% and 77.78% of the tested MDR bacteria, at MIC/2 at MIC/4 respectively, with 2 to 16-folds decreasing of MIC. This suggests the antibiotic resistance modulating effects of these antibiotics.ConclusionThe present study provides data indicating a possible use of the leaves extract of Recinodindron heudelotii alone or in association with common antibiotics in the fight against bacterial infections including those involving MDR bacteria.

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Antioxidant activities of some cameroonian plants extracts used in the treatment of intestinal and infectious diseases

Cited by 29 publications

References 14 publications

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Comparative Phytochemical Constituents and Antioxidant Activity of Wild and Cultivated Alepidea amatymbica Eckl & Zeyh

Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

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