2013
DOI: 10.2478/intox-2013-0031
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Abstract: Quercetin is a natural polyphenol with proven health beneficial activities. In this study 15 new quercetin derivatives were prepared with the aim to enhance their bioavailability. Modification of their physicochemical properties could herewith improve the action in cells. The prepared compounds were tested for their antioxidant and cytotoxic activity. The ability to scavenge free radicals as well as ferric reducing antioxidant power of the new derivatives was not better than that of unmodified quercetin. But f… Show more

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Cited by 72 publications
(44 citation statements)
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“…Stability longer than 30 days was observed only in samples stored at 37 ∘ C. As for the analysis of cytotoxicity in vitro, it is very clearly established that lineage NIH/3T3 is a powerful tool for this type of study [32]. In the literature, different effects of the cytotoxic behavior have been described, depending on the type of chemical substance, concentration, system for delivering substances, and type of cell lineage, using the MTT assay, using NIH/3T3 and other kind of cells [33,34]. The AO and AN samples exhibited a higher concentration-dependent profile after 48 hours of exposure (Figure 2).…”
Section: Discussionmentioning
confidence: 99%
“…Stability longer than 30 days was observed only in samples stored at 37 ∘ C. As for the analysis of cytotoxicity in vitro, it is very clearly established that lineage NIH/3T3 is a powerful tool for this type of study [32]. In the literature, different effects of the cytotoxic behavior have been described, depending on the type of chemical substance, concentration, system for delivering substances, and type of cell lineage, using the MTT assay, using NIH/3T3 and other kind of cells [33,34]. The AO and AN samples exhibited a higher concentration-dependent profile after 48 hours of exposure (Figure 2).…”
Section: Discussionmentioning
confidence: 99%
“…The CAA values of Ac‐PMEP 2 and Ac‐PMEP 3 were increased compared with PMEP in the PBS wash protocol ( P < 0.05). The acetyl groups probably helped PMEP to penetrate through the cell membranes (Danihelová, Veverka, Šturdík, & Jantová, ). There was no significant difference between the CAA values of Ac‐PMEP 1 and PMEP (Table ).…”
Section: Discussionmentioning
confidence: 99%
“…27 The screening results showed that these compounds were found non-toxic even at 250 μg/mL and displays allowable values of cell viability. (Figure 3) …”
Section: Cytotoxicitymentioning
confidence: 99%