Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat

Shirwaikar, Annie; Khan, Saleemulla; Malini, S.

doi:10.1016/j.jep.2003.08.004

Cited by 139 publications

(111 citation statements)

References 6 publications

(5 reference statements)

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“…The number of positively stained osteoclast in the section of the median portion of the whole femora was enumerated for the all groups. 22,23 ( Figure 8 and 9). …”

Section: Histopathology Of Femur Bone and Osteoclast Examinationmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Voltage-Gated Calcium Channels (Cav) Blocker on Ovariectomy Induced Osteoporosis in Rats

Chidrawar¹,

Alsalman²,

Sangi³

2016

JYP

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Objective: The present study was conducted to investigate the effect of two different doses of two calcium channel blockers i.e. verapamil and nifedipine on genesis and control of osteoporosis by considering various biochemical and bone parameters against ovariectomized (OVX) rat model. Methods: We have used total 42 female albino Wistar rats; one group of 6 animals was kept as Sham operated group. OVX was perform on 36 rats, after 14 days of recovery period; 36 OVX rats were equally and randomly divided into 06 groups, 4 groups for verapamil and nifedipine (two doses for each); one as disease control other is treated as standard. On 41 st day, various parameters evaluated. Results: Low dose of verapamil treated group have P<0.01 significant improvement in bone development; increasing in the bone density, breaking strength and maintaining serum calcium, phosphorous and ALP level. It also reduced the osteoclast count and maintained normal bone architecture. Conclusion: From the above study we conclude that there is involvement of specific Cav 1.1 and Cav 1.3 channels on rat osteoblast cells. Protection offered by low dose of verapamil possibly by controlling entry of Ca 2+ ions through these channels, inhibiting osteoclast formation and extending osteoblast survival.

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“…The number of positively stained osteoclast in the section of the median portion of the whole femora was enumerated for the all groups. 22,23 ( Figure 8 and 9). …”

Section: Histopathology Of Femur Bone and Osteoclast Examinationmentioning

confidence: 99%

“…The fresh bones and vertebrae were placed in hardness compressor, until it fractured. The reading were recorded in Newton's 23 (Refer Figure 7).…”

Section: Bone Mineral Density (Bmd) Measurement By Dual Energy X-ray mentioning

confidence: 99%

Effect of Voltage-Gated Calcium Channels (Cav) Blocker on Ovariectomy Induced Osteoporosis in Rats

Chidrawar¹,

Alsalman²,

Sangi³

2016

JYP

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“…The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect [18].…”

Section: Anti-osteoporotic Activitymentioning

confidence: 99%

Pharmacognostical, Phytochemical and Pharmacological Overview: Cissus quadrangularis Linn.

Pathak

Kambuja

Sachan

et al. 2015

IJPBR

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Cissus quadrangularis (Linn) has been used by the common man in India, and neighboring countries, Pakistan, Sri Lanka, Malaysia for promotion of fracture healing and well known as "Hadjod". It is also known as Vitis quadrangularis Wall. belongs to family Vitaceae. It is a common perennial climber, which is distributed throughout India, particularly in tropical regions. It requires warm tropical climate and propagated by stem cuttings. The plant is prescribed in the ancient Ayurvedic literature as a general tonic and analgesic, with specific bone fracture healing properties. The plant is believed to be useful in helminthiasis,

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“…The venotonic effect of CQ may also be postulated to be due to the effect of flavonoids present in the extract which act in the same way as that of diosmin and hesperidin. As diosmin and hesperidin are used in combination to treat hemorrhoid, the extract which produced the same activities (anti-inflammatory and Research Article IJBR 1 [3][2010] venotonic) can also be used as antihemorrhoidal drug 2 . The antiosteoporotic activity of CQ maybe justifiably is attributed to the steroids present which probably act as phytoestrogens to effectively prevent or reduce bone loss 3 .…”

Section: Introductionmentioning

confidence: 99%

“…As diosmin and hesperidin are used in combination to treat hemorrhoid, the extract which produced the same activities (anti-inflammatory and Research Article IJBR 1 [3][2010] venotonic) can also be used as antihemorrhoidal drug 2 . The antiosteoporotic activity of CQ maybe justifiably is attributed to the steroids present which probably act as phytoestrogens to effectively prevent or reduce bone loss 3 . Ethanlic extract of CQ inhibits gastric damage by enhancement in antioxidant defence enzymes in gastric mucosal tissues.…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Depressant Activity of Aqueous Extract of Cissus Quadrangularis

Mundada¹,

Agrawal²,

Dewade³

et al. 2011

Int Jour of Biomed Res

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The research work deals with the screening of aqueous extracts of Cissus quadrangularis (CQ) stem for central nervous system (CNS) depressant activity. The CQ leaves and stems contain resveratrol, piceatannol, pallidol perthenocissin derivatives as chemical components and are reported to have anticonvulant activity. The extract of plant showed GABA Abenzodiazepine receptor binding activity we made an attempt to study its CNS depressant effect. The different activities studied were test for locomotor activity, effect on muscle coordination, antiaggressive and antianxiety activities. The result of the study reflected that aqueous extract of the stem (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity

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Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat

Cited by 139 publications

References 6 publications

Effect of Voltage-Gated Calcium Channels (Cav) Blocker on Ovariectomy Induced Osteoporosis in Rats

Effect of Voltage-Gated Calcium Channels (Cav) Blocker on Ovariectomy Induced Osteoporosis in Rats

Pharmacognostical, Phytochemical and Pharmacological Overview: Cissus quadrangularis Linn.

Central Nervous System Depressant Activity of Aqueous Extract of Cissus Quadrangularis

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