Antinuclear and anti-single-stranded DNA antibodies in morphea and generalized morphea

Nodular morphea keloidal type: A rare case with paradigmatic histopathology significantly accompanied by a flawless surgical scar

“…Another element in favor of our diagnosis is the rich cellular population focally gathered in long ribbons, which predominates over the collagen component. This finding does not match any classic description of authentic keloids, whereas it has been reported in acknowledged cases of keloidal morphea 10‐19 . This population of large cells with plump nuclei and spindle‐shaped elements with tapering nuclei should be histopathologically differentiated from a few cutaneous mesenchymal tumors that may simulate keloidal overgrowths.…”

“…In fact, in classical morphea, variable ANA positivity (18-68%) and, less frequently, the presence of anti-dsDNA and anti-ENA antibodies have been reported. 14,15 Furthermore, the uncommon association of sclerodermatous nodules with classical morphea is rarely complicated by multi-organ involvement and only anecdotally accompanied by ANA positivity. 16 Conversely, these nodules are usually associated to systemic sclerosis with multi-organ involvement and serological signs of autoimmune disease.…”

Morphea in Adults and Children Cohort III

“…Although our results are similar to prior studies in that there is a trend toward an association between ssDNA ab and linear subtype, 5,14,15 the prevalence is far lower (29%–39% in prior reports). 5,6 We confirmed that AHA may be more frequently present in patients with linear morphea than in controls (18%) (although this association did not retain significance with correction for multiple comparisons), but we failed to find an association between the presence of these AHAs and generalized morphea in contrast to prior reports by Sato et al 7 The prevalence of antihistone antibodies in our study was also lower than in prior studies (39%–42% in prior reports). 5,7 These differences may represent referral bias among rheumatologist-assembled cohorts as well as differences in study populations and assays.…”

Elevated soluble CD23 levels in the sera from patients with localized scleroderma

“…Falanger et al [3] showed that anti-ssDNA antibody is associated with extensive disease, joint contraction, and active disease of more than 2 years' duration in linear scleroderma. They also revealed that the frequency of anti-ss-DNA antibody is higher in patients with clinical evidence of active compared with inactive disease in morphoea and generalized morphoea [4]. Furthermore, we reported the correlation of anti-ssDNA antibody with muscle involvement in patients with linear scleroderma [9].…”