Antinociceptive, anticonvulsant and antibacterial effects of the essential oil from the flower heads ofEgletes viscosa L

Abstract

The essential oil from flower heads of Egletes viscosaL. was investigated for possible antinociceptive, anticonvulsant effects in mice and for antibacterial efficacy against resistant Staphylococcus aureus in vitro. It was found to possess a significant dose‐dependent analgesic activity as assessed by acetic acid writhing and formalin tests and also an anticonvulsant activity against convulsions induced by pentylenetetrazol in mice. The plant oil displayed good antibacterial activity against resistant strains of S. aureus with the minimal inhibitory concentrations (MIC) ranging from 0.625 to 2.5 μL/mL. © 1998 John Wiley & Sons, Ltd.

Studies on anti-inflammatory and analgesic activities of betel nut in rodents

“…On the other hand, opioid receptor agonists, such as morphine exert an analgesic effect via inhibiting the initial phase of formalininduced nociception (Souza et al, 1998). Pretreatment of animals with Areca catechu extract or its aqueous fraction inhibited the 2nd phase of formalin-induced nociception at maximum tested dose by 46.3 ± 0.18 and 78.8 ± 1.10% respectively, similar to aspirin (52.9 ± 2.18%).…”

Essential Oils and Their Constituents: Anticonvulsant Activity

“…Six families, corresponding to 46 % of the total, are represented by only one species. Some of these species have other biological activities and are used for different purposes, like Egletes viscosa (L.) Less [ 6 ], also mentioned for their antimicrobial activity.…”

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

“…Briefly, 0.1 ml/10 g body weight of a 0.8% (v/v) acetic acid solution in saline was administered by intraperitoneal injection. Abdominal contortions were counted during a 20-min period, starting 10 min after acetic acid injection (10). Antinociceptive activity was expressed as the reduction of the number of abdominal constrictions.…”

“…Briefly, 20 µl of a 1% (v/v) solution of formalin in saline was injected into the subplantar region of the right hind paw. The time the animal spent licking the paw during the first 5 min (early phase) and from 20 to 25 min (late phase) post-injection served as measures of sensitivity (10). The test was done at ambient temperature of 22-26ºC and care was taken to exclude environmental disturbances (high temperature, noise and excessive movement) that might interfere with the animal's response (13).…”