Antinociceptive Activities and the Mechanisms of Anti‐Inflammation of Asiatic Acid in Mice

Huang, Shyh-Shyun; Chiu, Chuan-Sung; Chen, Hsien-Jung; Hou, Wen Chi; Sheu, Ming‐Jyh; Lin, Ying-Chih; Shie, Pei-Hsin; Huang, Guan‐Jhong

doi:10.1155/2011/895857

Cited by 121 publications

(96 citation statements)

References 42 publications

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“…6,7) Asiatic acid isolated from P. chinensis has several health benefits and has thus attracted medical and research professionals. Previous studies have shown that Asiatic acid has a variety of pharmacological effects on anti-inflammation, 8,9) anti-tumor, 10) neuroprotection. 11) In particular, Asiatic acid has been shown to be a hepatoprotective agent.…”

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confidence: 99%

Retraction: Asiatic Acid from Potentilla chinensis Attenuate Ethanol-Induced Hepatic Injury via Suppression of Oxidative Stress and Kupffer Cell Activation

Wei

Huang

et al. 2013

Biological & Pharmaceutical Bulletin

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This study examined the effect of Asiatic acid from Potentilla chinensis (AAPC) on chronic ethanolinduced hepatic injury. Rats underwent intragastric administration of ethanol (5.0-9.0 g/kg) once a day for 12 weeks. A subset of rats were also intragastrically treated with AAPC (2, 4 or 8 mg/kg) once a day. In the end, AAPC treatment significantly protected against ethanol-induced liver injury, as evidenced by the decrease in serum alanine and aspartate aminotransferases levels and the attenuation of histopathological changes in rats. Additionally, AAPC significantly decreased blood alcohol and acetaldehyde concentrations by enhancing alcohol dehydrogenase and aldehyde dehydrogenase activities. Mechanistically, studies showed that AAPC remarkably alleviated the formations of malondialdehyde and myeloperoxidase, restored impaired antioxidants, including superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase, and inhibited cytochrome P450 (CYP)2E1 activity. Moreover, the over-expression of cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the elevated plasma endotoxin level and the up-regulated Toll-like receptor 4 (TLR4), CD14 and myeloid differentiation factor 88 (MyD88) as well as nuclear factor-κB were also suppressed by AAPC in ethanol-intoxicated rats. In conclusion, the protective effect of AAPC on ethanol-induced hepatotoxicity was mainly due to its ability to attenuate oxidative stress and inhibit Kupffer cell activation by decreasing the level of plasma endotoxin and the expression of TLR4, CD14 and MyD88.

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confidence: 99%

Retraction: Asiatic Acid from Potentilla chinensis Attenuate Ethanol-Induced Hepatic Injury via Suppression of Oxidative Stress and Kupffer Cell Activation

Wei

Huang

et al. 2013

Biological & Pharmaceutical Bulletin

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“…Polyphenols act as antioxidants via several mechanisms including the scavenging of free radicals and chelation of transition metals, as well as the mediation and inhibition of enzymes [19]. The use of traditional medicine is widespread and plants still present a large source of natural antioxidants that might serve as leads for the development of novel drugs.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Antinociceptive, and Anti-Inflammatory Activities fromActinidia callosavar.callosa In VitroandIn Vivo

Liao

Deng

Lin

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Actinidia callosa var. callosa has been widely used to treat antipyretic, analgesic, anti-inflammation, abdominal pain, and fever in Taiwan. The aim of this study was to evaluate the antioxidant, antinociceptive, and anti-inflammatory lipopolysaccharide-(LPS-)induced nitric oxide (NO) production in RAW264.7 macrophages and pawedema induced by λ-carrageenan activities of the methanol extract from A. callosa. In HPLC analysis, the fingerprint chromatogram of ethyl-acetate fraction of A. callosa (EAAC) was established. EAAC showed the highest TEAC and DPPH radical scavenging activities, respectively. We evaluated that EAAC and the reference compound of catechin and caffeic acid decreased the LPS-induced NO production in RAW264.7 cells. Treatment of male ICR mice with EAAC significantly inhibited the numbers of acetic acid-induced writhing response and the formalin-induced pain in the late phase. Administration of EAAC showed a concentration-dependent inhibition on paw edema development after Carr treatment in mice. Anti-inflammatory mechanisms of EAAC might be correlated to the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) in vitro and in vivo. Overall, the results showed that EAAC demonstrated antioxidant, antinociceptive, and anti-inflammatory activity, which supports previous claims of the traditional use for inflammation and pain.

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“…In another study, the aqueous and alcoholic extract of C. asiatica showed 46.31% and 71.18%, respectively, inhibition of edema after 3 hrs, while the standard ibuprofen showed an inhibition of 66.66% [38]. At the 4 th and 5 th hrs, after λ-carrageenan (Carr) supplementation, the asiatic acid reduced paw edema by regulation of catalase, superoxide dismutase (SOD), and glutathione in the liver tissue [39]. In another study, measurement of paw size was taken before carrageenan injection and then 1, 2, 3, and 4 hrs after carrageenan injection.…”

Section: Anti-inflammatory Activitymentioning

confidence: 98%

A Review on Medicinal Properties of Centella Asiatica

Prakash

Jaiswal

Srivastava

2017

Asian J Pharm Clin Res

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Plant-based drug discovery has drawn the attention of researchers, especially the one used as traditional medicines. Centella asiatica is traditional Ayurveda medicine widely used in India and across Asia for treating a variety of diseases. The aerial parts and roots are used for medicinal purpose, and its chemical constituents have wide therapeutic applications in areas of antimicrobial, anti-inflammatory, anticancer, neuroprotective, antioxidant, and wound healing activities. Many of its uses have been proven scientifically, and bioactive ingredients have been validated. In this review, we have done a critical evaluation of available literature looking for the pharmacological importance of C. asiatica. Further studies will be helpful to discover more bioactive compounds their exact mode of actions.

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Antinociceptive Activities and the Mechanisms of Anti‐Inflammation of Asiatic Acid in Mice

Cited by 121 publications

References 42 publications

Retraction: Asiatic Acid from <i>Potentilla chinensis</i> Attenuate Ethanol-Induced Hepatic Injury <i>via</i> Suppression of Oxidative Stress and Kupffer Cell Activation

Retraction: Asiatic Acid from <i>Potentilla chinensis</i> Attenuate Ethanol-Induced Hepatic Injury <i>via</i> Suppression of Oxidative Stress and Kupffer Cell Activation

Antioxidant, Antinociceptive, and Anti-Inflammatory Activities fromActinidia callosavar.callosa In VitroandIn Vivo

A Review on Medicinal Properties of Centella Asiatica

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