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“…First, although still generalizable to the majority of patients with AAV [1820], extrapolation of our findings to ANCA-negative patients is not possible. Second, our data derive from a post hoc clinical trial analysis and therefore should be confirmed in additional prospective studies.…”
Section: Discussionmentioning
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“…First, although still generalizable to the majority of patients with AAV [1820], extrapolation of our findings to ANCA-negative patients is not possible. Second, our data derive from a post hoc clinical trial analysis and therefore should be confirmed in additional prospective studies.…”
Section: Discussionmentioning
“…ANCA is classified into two main groups according to the fluorescence appearance on ethanol fixed neutrophil preparations: perinuclear (p) ANCA and cytoplasmic (c) ANCA. In MPA, pANCA is seen and myeloperoxidase (MPO) is the principal target antigen 9. ANCA is thought to contribute to the immunoinflammatory process in these vasculitides.…”
mentioning
“…Translocation and release of these cytoplasmic components is part of the physiological response of neutrophils to inflammatory mediators such as TNFα 18. In vitro studies show that antibodies to PC3 (PC3-ANCA) bind to neutrophils and induce respiratory bursts and degranulation possibly beyond what is physiologically appropriate.…”
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