Antineoplastic and Antiviral Activities of Podophyllotoxin Related Lignans

Abstract

28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1 microM; deoxypodophyllotoxin (1) being the most potent compound in all cases.

Antiproliferative activity of yatein isolated fromAustrocedrus chilensisagainst murine myeloma cells: Cytological studies and chemical investigations

“…To date, some of the most important studied metabolites are podophyllotoxin and its hemisynthetic derivatives (etoposide, teniposide, and etoposide phosphate), which are particularly interesting due to their ability to inhibit tumor cell proliferation, making them useful in chemotherapy for the treatment of lung cancer (Ayres & Loik, 1990;Gordaliza et al, 2006;Yang et al, 2007).…”

A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport

“…As a promising microtubule inhibitor candidate, DPT possesses various pharmacological activities, including anti-inflammatory (Jin et al, 2008), anti-viral (Gordaliza et al, 1994), anti-angiogenic (Wang et al, 2015a, and anti-tumor effects, among which anti-tumor attracted most attention. Previous studies have shown that DPT inhibits the proliferation of SGC-7901 cancer cells and induces G2/M cell cycle arrest (Wang et al, 2015b).…”

Molecular modelling evaluation of the cytotoxic activity of podophyllotoxin analogues

“…This group is commonly called as pyrazolignans [19,20,24,25,27] and isoxazolignans [25,26,28,29] and they were obtained by reacting podophyllotoxine with differently substituted hydrazines and hydroxylamines.…”

“…Structural modification mainly introduced varying radicals at position 7 in podophyllotoxin scaffold. Reports have been made of compounds with oxygenated substituents in the form of ethers, esters and diverse nitrogen radicals [17][18][19][20][21][22][23][24][25][26].…”