Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

Abstract

Aim This study evaluated the effects of 5‐fluorouracil (5‐FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. Methods One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post‐treatment. Histological, histometric (percentage of bone in the furcation [PBF]) and immunohistochemical (for tumour necrosis factor‐α, interleukin‐1β and receptor activator of nuclear factor‐κB ligand) analyses were performed. Data were statistically analysed. Results CIS‐NEP and 5FU‐NEP showed more inflammation than PSS‐NEP at 3, 5 and 7 days. CIS‐EP and 5FU‐EP showed more inflammation and lower PBF than PSS‐EP at all periods of evaluation. 5FU‐EP showed lower PBF than CIS‐EP at 5 and 7 days. Conclusion 5‐FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages.

Influence of the treatment with the antineoplastic agents 5-fluorouracil and cisplatin on the severity of experimental periodontitis in rats

“…Importantly, our study showed higher immunolabelling pattern of TNF-α and IL-1β in NEP-5FU and NEP-CIS when compared with NEP-PSS. This result represents increased expression of proin ammatory cytokines in healthy periodontal tissues and corroborates with Gusman et al 2019 [15], that while assessing the in uence of 5-FU and CIS on healthy periodontium at 3, 5 and 7 days, also observed higher immunolabelling pattern of TNF-α and IL-1β.…”

“…NEP-5FU and EP-5FU were treated with 5-FU, and NEP-CIS and EP-CIS were treated with CIS. Each animal received two intraperitoneal injections of either PSS (Equiplex Indústria Farmacêutica, Aparecida de Goiânia, GO, Brazil), 5-FU (Fluorouracila, 250 mg/10 mL, Eurofarma Laboratórios, São Paulo, SP, Brazil) or CIS (Fauldcispla, 10 mg/10 ml, Libbs Farmacêutica, São Paulo, SP, Brazil) at day 0 (5-FU, 60 mg/Kg; CIS, 5 mg/Kg) and day 2 (48 h later) (5-FU, 40 mg/Kg; CIS, 2,5 mg/Kg), in accordance with Gusman et al (2018) [15]. At day 0, after general anesthesia (cloridrato de cetamina − 70 mg/Kg [Syntec, Santana de Parnaíba, SP, Brazil], cloridrato de xilazina − 6 mg/Kg [Syntec, Santana de Parnaíba, SP, Brazil], intramuscular injection), a #24 (Corrente Algodão n°24, Coats Corrente, São Paulo, SP, Brazil) cotton thread was placed around both lower rst molars to induce EP in groups EP-PSS, EP-5FU and EP-CIS [17,18].…”

“…Furthermore, 5-FU negatively affected the periodontal repair following scaling and root planning (SRP) [12]. With regard to CIS, recent experimental research reported exacerbation of periodontal in ammation in the early periods of EP [15]. However, there are still limited evidences to clarify the in uence of chemotherapy as a modifying factor in the progression of periodontitis.…”

Influence of the treatment with the antineoplastic agents 5-fluorouracil and Cisplatin on the severity of experimental periodontitis in rats

“…NEP-5FU and EP-5FU were treated with 5-FU, and NEP-CIS and EP-CIS were treated with CIS. Each animal received two intraperitoneal injections of either PSS (Equiplex Indústria Farmacêutica, Aparecida de Goiânia, GO, Brazil), 5-FU (Fluorouracila, 250 mg/10 mL, Eurofarma Laboratórios, São Paulo, SP, Brazil) or CIS (Fauldcispla, 10 mg/10 ml, Libbs Farmacêutica, São Paulo, SP, Brazil) at day 0 (5-FU, 60 mg/Kg; CIS, 5 mg/Kg) and day 2 (48 h later) (5-FU, 40 mg/Kg; CIS, 2,5 mg/Kg), in accordance with Gusman et al (2018) [15].…”

Modern view on integrated treatment of patients with chronic localized periodontitis of medium severity (a literature review)

“…Срок пользования подобной шины определяется имеющейся подвижностью зубов, гигиеной полости рта и методами терапевтического лечения заболеваний тканей пародонта. Недостатками этого метода являются отсутствие эстетики, возможность травмирования здоровых зубов, вероятность возникновения маргинального пародонта, отсутствие точности [65].…”