Antimyosin Scintigraphy Compared With Magnetic Resonance Imaging in Inflammatory Myopathies

Abstract

Antimyosin scintigraphy and T2-weighted MRI are feasible tools for the detection and follow-up of lesions in patients with myositis. Scintigraphy findings correlate with serum creatine kinase activity and seem to reflect disease activity better than T2-weighted MRI changes, whereas secondary degenerative intramuscular lesions are only detectable using T1-weighted MRI.

Combining MRI and muscle biopsy improves diagnostic accuracy in subacute‐onset idiopathic inflammatory myopathy

“…In triage, MRI is used before the muscle biopsy to select the most suitable site to decrease sampling error and thus reduce false negative findings. Recommendations to perform MRI as a guide for muscle biopsy are based on 4 relatively small studies, and on studies including only patients with an established diagnosis of IIM . MRI can also be helpful as an add‐on test in patients with a negative muscle biopsy who have a clinical presentation consistent with subacute‐onset IIM.…”

Combining MRI and muscle biopsy improves diagnostic accuracy in subacute‐onset idiopathic inflammatory myopathy

“…In triage, MRI is used before the muscle biopsy to select the most suitable site to decrease sampling error and thus reduce false negative findings. Recommendations to perform MRI as a guide for muscle biopsy are based on 4 relatively small studies, and on studies including only patients with an established diagnosis of IIM . MRI can also be helpful as an add‐on test in patients with a negative muscle biopsy who have a clinical presentation consistent with subacute‐onset IIM.…”

Magnetic Resonance Imaging of the Skeletal Musculature

“…Uptake of antimyosin antibody in the legs correlates with myositis activity based on CK levels (Lofberg et al 1998). Uptake of antimyosin antibody in the legs correlates with myositis activity based on CK levels (Lofberg et al 1998).…”

Application of Radioisotopes in Inflammation

“…111 In-altumomab is a conjugated-111 In-labeled monoclonal antibody against myosin. In patients with myositis, overexpression of myosin protein at the outer cell membrane of inflammatory cells makes it a suitable target for specific antimyosin antibody scintigraphy in the diagnosis and follow-up of patients with myositis [20]. Table 2 shows the specifications of some 111 In-labeled antibodies in inflammation studies.…”

Combining MRI and muscle biopsy improves diagnostic accuracy in subacute‐onset idiopathic inflammatory myopathy

“…In triage, MRI is used before the muscle biopsy to select the most suitable site to decrease sampling error and thus reduce false negative findings. Recommendations to perform MRI as a guide for muscle biopsy are based on 4 relatively small studies, and on studies including only patients with an established diagnosis of IIM . MRI can also be helpful as an add‐on test in patients with a negative muscle biopsy who have a clinical presentation consistent with subacute‐onset IIM.…”

Magnetic Resonance Imaging of the Skeletal Musculature

“…Uptake of antimyosin antibody in the legs correlates with myositis activity based on CK levels (Lofberg et al 1998). Uptake of antimyosin antibody in the legs correlates with myositis activity based on CK levels (Lofberg et al 1998).…”

Application of Radioisotopes in Inflammation

“…111 In-altumomab is a conjugated-111 In-labeled monoclonal antibody against myosin. In patients with myositis, overexpression of myosin protein at the outer cell membrane of inflammatory cells makes it a suitable target for specific antimyosin antibody scintigraphy in the diagnosis and follow-up of patients with myositis [20]. Table 2 shows the specifications of some 111 In-labeled antibodies in inflammation studies.…”

Combining MRI and muscle biopsy improves diagnostic accuracy in subacute‐onset idiopathic inflammatory myopathy

“…In triage, MRI is used before the muscle biopsy to select the most suitable site to decrease sampling error and thus reduce false negative findings. Recommendations to perform MRI as a guide for muscle biopsy are based on 4 relatively small studies, and on studies including only patients with an established diagnosis of IIM . MRI can also be helpful as an add‐on test in patients with a negative muscle biopsy who have a clinical presentation consistent with subacute‐onset IIM.…”

Magnetic Resonance Imaging of the Skeletal Musculature

“…Uptake of antimyosin antibody in the legs correlates with myositis activity based on CK levels (Lofberg et al 1998). Uptake of antimyosin antibody in the legs correlates with myositis activity based on CK levels (Lofberg et al 1998).…”

Application of Radioisotopes in Inflammation

“…111 In-altumomab is a conjugated-111 In-labeled monoclonal antibody against myosin. In patients with myositis, overexpression of myosin protein at the outer cell membrane of inflammatory cells makes it a suitable target for specific antimyosin antibody scintigraphy in the diagnosis and follow-up of patients with myositis [20]. Table 2 shows the specifications of some 111 In-labeled antibodies in inflammation studies.…”