“…Vanillin possesses potent antimutagenic properties, exemplified by its ability to reduce the extent of DNA lesions induced by several chemical mutagens (Ohta et al, 1986), UV light (Takahashi et al, 1990), as well as spontaneous mutations (Shaughnessy et al, 2006) in different Esherichia coli strains, mitomycin C-induced DNA lesions in (hybrid) Chinese hamster ovary cells (Sasaki et al, 1987;Gustafson et al, 2000), mouse bone marrow cells (Inouye et al, 1988), and somatic cells of Drosophila melanogaster (Santos et al, 1999), as well as X-ray-, UV light-, or H 2 O 2 -induced mutations in bone marrowderived cells Maurya et al, 2007) and hamster fibroblasts (V79 cells) Tamai et al, 1992) and hybrid ovary cells (Gustafson et al, 2000). In human mismatch repair-deficient (hMLH1 2 ) HCT116 colon cancer cells, vanillin decreased the number of spontaneous mutations in a concentrationdependent manner (19-73% at concentrations of 0.5--2.5 mM) (King et al, 2007). Vanillin also improved the efficacy of DNA damage repair mechanisms under conditions of oxidative stress (Maurya et al, 2007) and in spontaneously mutating colon cancer (HCT116) cells (King et al, 2007).…”