2016
DOI: 10.1186/s13017-016-0089-y
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Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient… Show more

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Cited by 139 publications
(191 citation statements)
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References 291 publications
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“…Part of non-fermenting Gram-negative bacteria (Pseudomonas aeruginosa and Acinetobacter baumannii) wasn't high (7,6%). However, taking into account their potential multi-drug resistance (MDR) (Centers for Disease Control and Prevention US Department of Health and Human Services 2013; Sartelli et al 2016;Moolchandani et al 2017), the presence of this bacteria in the microbiological profile of emergency surgical diseases is important in the antibiotic therapy preferences.…”
Section: Resultsmentioning
confidence: 99%
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“…Part of non-fermenting Gram-negative bacteria (Pseudomonas aeruginosa and Acinetobacter baumannii) wasn't high (7,6%). However, taking into account their potential multi-drug resistance (MDR) (Centers for Disease Control and Prevention US Department of Health and Human Services 2013; Sartelli et al 2016;Moolchandani et al 2017), the presence of this bacteria in the microbiological profile of emergency surgical diseases is important in the antibiotic therapy preferences.…”
Section: Resultsmentioning
confidence: 99%
“…Particularly, in complicated intra-abdominal infections a high prevalence of polymicrobial spectrum and antimicrobial resistance had been monitored (Kurup et al 2014) In the present study, the part of the Gram-negative bacteria in primary samples of emergency surgical diseases was 32,1%. This group of pathogens is always problematic for treatment and could have a potential value as a source for further intra-hospital spreading (Kaye & Pogue 2015;Sartelli et al 2016;Exner et al 2017). In addition, considering the short courses of antibiotic therapy for patients with local surgical infection, there is a risk of drug-resistant strains emergence and their further spreading in general population.…”
Section: Resultsmentioning
confidence: 99%
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“…ESBL-synthesizing pathogens can inactivate almost all cephalosporins and in some cases also piperacillin/tazobactam. If ESBL producers are to be expected, carbapenems should generally be preferred, even though several clinically relevant ESBL variants (temoneira β-lactamase, TEM; sulfhydryl variable type β-lactamase, SHV; cefotaxime-Munich β-lactamase, CTX-M) may retain susceptibility to piperacillin/tazobactam [154]. If the antibiogram reveals an ESBL pathogen to be susceptible to piperacillin/tazobactam, treatment of urinary tract infections is usually unproblematic; however, for bacteremia, no consensus has been reached regarding the adequacy of therapy due to the inoculum effect [155] and the serious implications of altered β-lactam pharmacokinetics in sepsis patients [156,157].…”
Section: Sepsis Of Unknown Source Without Pretreatmentmentioning
confidence: 99%