Antimicrobial Silver Nanoparticles: Future of Nanomaterials

Arya, Geeta; Sharma, Nikita; Mankamna, R.; Nimesh, Surendra

doi:10.1007/978-3-030-16534-5_6

Cited by 30 publications

(26 citation statements)

References 108 publications

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“…When bacteria is treated with AgNPs, morphological changes are revealed in biofilm's architecture, such as uneven cell surface, suggesting cell lysis [70], relevant morphological damages in the cell wall, membrane corrugation damage, changes in membrane polarization and/or permeability [90], and distinct EPS-matrix formation surrounding the bacterial strains [91]. Moreover, electrostatic interactions between AgNPs and bacterial membranes cause them to rupture, so that AgNPs can penetrate into the mature biofilm [86,92].…”

Section: Antibiofilm Mechanism Of Action Of Agnpsmentioning

confidence: 99%

Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains

et al. 2020

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Due to the severity of infections caused by P. aeruginosa and the limitations in treatment, it is necessary to find new therapeutic alternatives. Thus, the use of silver nanoparticles (AgNPs) is a viable alternative because of their potential actions in the combat of microorganisms, showing efficacy against Gram-positive and Gram-negative bacteria, including multidrug-resistant microorganisms (MDR). In this sense, the aim of this work was to conduct a literature review related to the antibacterial and antibiofilm activity of AgNPs against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains. The AgNPs are promising for future applications, which may match the clinical need for effective antibiotic therapy. The size of AgNPs is a crucial element to determine the therapeutic activity of nanoparticles, since smaller particles present a larger surface area of contact with the microorganism, affecting their vital functioning. AgNPs adhere to the cytoplasmic membrane and cell wall of microorganisms, causing disruption, penetrating the cell, interacting with cellular structures and biomolecules, and inducing the generation of reactive oxygen species and free radicals. Studies describe the antimicrobial activity of AgNPs at minimum inhibitory concentration (MIC) between 1 and 200 μg/mL against susceptible and MDR P. aeruginosa strains. These studies have also shown antibiofilm activity through disruption of biofilm structure, and oxidative stress, inhibiting biofilm growth at concentrations between 1 and 600 μg/mL of AgNPs. This study evidences the advance of AgNPs as an antibacterial and antibiofilm agent against Pseudomonas aeruginosa strains, demonstrating to be an extremely promising approach to the development of new antimicrobial systems.

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Section: Antibiofilm Mechanism Of Action Of Agnpsmentioning

confidence: 99%

Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains

et al. 2020

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“…[ 23 ]. Ag-NPs have distinctive antimicrobial qualities which make them efficient at different particle sizes and concentrations versus a wide spectrum of Gram-negative and Gram-positive pathogens, including multidrug-resistant and biofilm-forming bacteria [ 24 , 25 ]. Moreover, biogenic silver nanoparticles have been extensively used as anticancer agents for the clinical management of cancer, as mediated through a cytotoxic effect due to induced oxidative stress, reducing the viability and modifying the morphology of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Bactericidal and In-Vitro Cytotoxic Efficacy of Silver Nanoparticles (Ag-NPs) Fabricated by Endophytic Actinomycetes and Their Use as Coating for the Textile Fabrics

et al. 2020

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An endophytic strain of Streptomyces antimycoticus L-1 was isolated from healthy medicinal plant leaves of Mentha longifolia L. and used for the green synthesis of silver nanoparticles (Ag-NPs), through the use of secreted enzymes and proteins. UV–vis spectroscopy, Fourier-transform infrared (FT-IR), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) analyses of the Ag-NPs were carried out. The XRD, TEM, and FT-IR analysis results demonstrated the successful biosynthesis of crystalline, spherical Ag-NPs with a particle size of 13–40 nm. Further, the stability of the Ag-NPs was assessed by detecting the surface Plasmon resonance (SPR) at 415 nm for one month or by measuring the NPs surface charge (−19.2 mV) by zeta potential analysis (ζ). The green-synthesized Ag-NPs exhibited broad-spectrum antibacterial activity at different concentrations (6.25–100 ppm) against the pathogens Staphylococcus aureus, Bacillus subtilis Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhimurium with a clear inhibition zone ranging from (9.5 ± 0.4) nm to (21.7 ± 1.0) mm. Furthermore, the green-synthesized Ag-NPs displayed high efficacy against the Caco-2 cancerous cell line (the half maximal inhibitory concentration (IC50) = 5.7 ± 0.2 ppm). With respect to antibacterial and in-vitro cytotoxicity analyses, the Ag-NPs concentration of 100 ppm was selected as a safe dose for loading onto cotton fabrics. The scanning electron microscopy connected with energy-dispersive X-ray spectroscopy (SEM-EDX) for the nano-finished fabrics showed the distribution of Ag-NPs as 2% of the total fabric elements. Moreover, the nano-finished fabrics exhibited more activity against pathogenic Gram-positive and Gram-negative bacteria, even after 10 washing cycles, indicating the stability of the treated fabrics.

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“…Currently, the utilization of non-drug antimicrobial materials and coatings has been widely studied. This introduces nanomaterials, including silver ( Arya et al, 2019 ), gold ( Piktel et al, 2021 ), copper ( Usman et al, 2013 ), selenium ( Huang et al, 2019 ), titanium oxide ( Youssef et al, 2020 ), and zinc oxide ( Janaki et al, 2015 ) nanoparticles; carbon nanomaterials ( Azizi-Lalabadi et al, 2020 ); antimicrobial peptides ( Raheem and Straus, 2019 ); or chitosan ( Qi et al, 2004 ) which shows more or less antimicrobial effectiveness by themselves toward a specific type of bacteria. Therefore, the different strategies and combinations of various materials, geometries, and chemistry are emerging today to find enhanced antibacterial efficiency.…”

Section: Introductionmentioning

confidence: 99%

Modifications of Parylene by Microstructures and Selenium Nanoparticles: Evaluation of Bacterial and Mesenchymal Stem Cell Viability

Pekárková

Gablech

Fialova

et al. 2021

Front. Bioeng. Biotechnol.

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Parylene-based implants or coatings introduce surfaces suffering from bacteria colonization. Here, we synthesized polyvinylpyrrolidone-stabilized selenium nanoparticles (SeNPs) as the antibacterial agent, and various approaches are studied for their reproducible adsorption, and thus the modification of parylene-C–coated glass substrate. The nanoparticle deposition process is optimized in the nanoparticle concentration to obtain evenly distributed NPs on the flat parylene-C surface. Moreover, the array of parylene-C micropillars is fabricated by the plasma etching of parylene-C on a silicon wafer, and the surface is modified with SeNPs. All designed surfaces are tested against two bacterial pathogens, Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). The results show no antibacterial effect toward S. aureus, while some bacteriostatic effect is observed for E. coli on the flat and microstructured parylene. However, SeNPs did not enhance the antibacterial effect against both bacteria. Additionally, all designed surfaces show cytotoxic effects toward mesenchymal stem cells at high SeNP deposition. These results provide valuable information about the potential antibacterial treatment of widely used parylene-C in biomedicine.

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Antimicrobial Silver Nanoparticles: Future of Nanomaterials

Cited by 30 publications

References 108 publications

Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains

Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains

Bactericidal and In-Vitro Cytotoxic Efficacy of Silver Nanoparticles (Ag-NPs) Fabricated by Endophytic Actinomycetes and Their Use as Coating for the Textile Fabrics

Modifications of Parylene by Microstructures and Selenium Nanoparticles: Evaluation of Bacterial and Mesenchymal Stem Cell Viability

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