Antimicrobial resistance in commensal Staphylococcus aureus from wild ungulates is driven by agricultural land cover and livestock farming

Ramos, Beatriz; Rosalino, Luís Miguel; Palmeira, Josman Dantas; Torres, Rita T.; Cunha, Mónica V.

doi:10.1016/j.envpol.2022.119116

Cited by 15 publications

(9 citation statements)

References 52 publications

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“…There is evidence that these populations share resources with extensive farms [ 62 ], which could facilitate the exchange of S. aureus strains in the environment. The increase in wild boar populations and this species’ good adaptability have led to wild boars’ opportunistic foraging and feeding behavior near human settings, which encourages contact with human populations [ 63 ]. However, most of the isolates recovered from these species belonged to wildlife-associated lineages and lacked IEC genes.…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of Staphylococcus aureus in Wildlife

Martínez-Seijas

Mascarós

Lizana

et al. 2023

Animals

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Staphylococcus aureus is an opportunistic multi-host pathogen that threatens both human and animal health. Animals can act as a reservoir of S. aureus for humans, but very little is known about wild animals’ epidemiological role. Therefore, in this study, we performed a genomic characterization of S. aureus isolates from wildlife, hunters, and their auxiliary hunting animals of Eastern Spain. Of 20 different species, 242 wild animals were examined, of which 28.1% were S. aureus carriers. The common genet, the Iberian ibex, and the European hedgehog were the species with the highest S. aureus carriage. We identified 30 different sequence types (STs), including lineages associated with wild animals such as ST49 and ST581, multispecies lineages such as ST130, ST398, and ST425, and lineages commonly isolated from humans, including ST1 and ST5. The hunters and the single positive ferret shared ST5, ST398, or ST425 with wild animals. In wildlife isolates, the highest resistance levels were found for penicillin (32.8%). For virulence factors, 26.2% of them carried superantigens, while 14.8% harbored the immune evasion cluster (IEC), which indicates probable human origin. Our findings suggest that wild animals are a reservoir of clinically relevant genes and lineages that could have the potential to be transmitted to humans. These data support the notion that wildlife surveillance is necessary to better understand the epidemiology of S. aureus as a pathogen that circulates among humans, animals, and the environment.

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Section: Discussionmentioning

confidence: 99%

Genomic Characterization of Staphylococcus aureus in Wildlife

Martínez-Seijas

Mascarós

Lizana

et al. 2023

Animals

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“…Some studies emphasize that commensal Staphylococcus spp. species is a good reservoir for virulence genes [ 35 , 36 , 37 ]. Gene transfer experiments were not performed in this study; however, they may be needed future studies.…”

Section: Discussionmentioning

confidence: 99%

The Characterization and Beta-Lactam Resistance of Staphylococcal Community Recovered from Raw Bovine Milk

et al. 2023

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Staphylococci is an opportunistic bacterial population that is permanent in the normal flora of milk and poses a serious threat to animal and human health with some virulence factors and antibiotic-resistance genes. This study was aimed at identifying staphylococcal species isolated from raw milk and to determine hemolysis, biofilm, coagulase activities, and beta-lactam resistance. The raw milk samples were collected from the Düzce (Türkiye) region, and the study data represent a first for this region. The characterization of the bacteria was performed with MALDI-TOF MS and 16S rRNA sequence analysis. The presence of coa, icaB, blaZ, and mecA was investigated with PCR. A nitrocefin chromogenic assay was used for beta-lactamase screening. In this context, 84 staphylococci were isolated from 10 different species, and the dominant species was determined as S. aureus (32.14%). Although 32.14% of all staphylococci were positive for beta hemolysis, the icaB gene was found in 57.14%, coa in 46.42%, mecA in 15.47%, and blaZ in 8.33%. As a result, Staphylococcus spp. strains that were isolated from raw milk in this study contained some virulence factors at a high level, but also contained a relatively low level of beta-lactam resistance genes. However, considering the animal–environment–human interaction, it is considered that the current situation must be monitored constantly in terms of resistance concerns. It must not be forgotten that the development of resistance is in constant change among bacteria.

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“…Other avian species have been described as being potential dispersants and reservoirs of AMR, such as shorebirds, with compound exposure linked to use in aquaculture (Carroll et al, 2014;Navedo et al, 2021). Antimicrobial resistance has also been reported in wild ungulates, where the pathway of transfer is via direct contact with domestic livestock as a consequence of human disturbance and habitat conversion to agricultural systems (Espunyes et al, 2021;Ramos et al, 2022). Some of these wild ungulates play an important role in transmission between environmental compartments, such as wild boar, with interactions between urban, agricultural, and natural environments (Torres et al, 2020).…”

Section: Amr Afr and The Microbiomementioning

confidence: 99%

“…In this context, scavenging birds have been identified as potential dispersants of AMR because of their likely exposure via domestic animal carcasses potentially treated with veterinary drugs and their capacity to travel long distances (Blanco et al, 2020). Some of the AMR organisms are zoonotic pathogens (i.e., Salmonella ) that are a particular concern from a human health and food safety standpoint, and some of these organisms have been reported in vultures and wild ungulates (Blanco, 2018; Marin et al, 2018; Ramos et al, 2022). Other avian species have been described as being potential dispersants and reservoirs of AMR, such as shorebirds, with compound exposure linked to use in aquaculture (Carroll et al, 2014; Navedo et al, 2021).…”

Section: Amr Afr and The Microbiomementioning

confidence: 99%

Do Pharmaceuticals in the Environment Pose a Risk to Wildlife?

Bean

Chadwick

Herrero‐Villar

et al. 2023

Enviro Toxic and Chemistry

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The vast majority of knowledge related to the question of, "To what extent do pharmaceuticals in the environment pose a risk to wildlife?", stems from the Asian vulture crisis (>99% decline of some species of old-world vultures on the Indian subcontinent related to the veterinary use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac). The hazard of diclofenac and other NSAIDs (carprofen, flunixin, ketoprofen, nimesulide, phenylbutazone) to vultures and other avian species has since been demonstrated; indeed only meloxicam and tolfenamic acid have been found to be vulture-safe. Since diclofenac was approved for veterinary use in Spain and Italy in 2013

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Antimicrobial resistance in commensal Staphylococcus aureus from wild ungulates is driven by agricultural land cover and livestock farming

Cited by 15 publications

References 52 publications

Genomic Characterization of Staphylococcus aureus in Wildlife

Genomic Characterization of Staphylococcus aureus in Wildlife

The Characterization and Beta-Lactam Resistance of Staphylococcal Community Recovered from Raw Bovine Milk

Do Pharmaceuticals in the Environment Pose a Risk to Wildlife?

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