Antimicrobial resistance and mortality following E. coli bacteremia

Daneman, Nick; Fridman, Daniel; Johnstone, Jennie; Langford, Bradley J; Lee, Samantha M.; MacFadden, Derek M.; Mponponsuo, Kwadwo; Patel, Samir N.; Schwartz, Kevin L; Brown, Kevin E.

doi:10.1016/j.eclinm.2022.101781

Cited by 14 publications

(6 citation statements)

References 14 publications

(24 reference statements)

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“…Other authors have also reported the highest AMR to this antibiotic, ranging from 40 to almost 100% in different studies worldwide, regardless of whether they were studies carried out in asymptomatic [47][48][49][50] or symptomatic [43,44,[51][52][53][54] dogs and cats. Moreover, these results have also been found in food-producing animals [17] and humans [51,55], which highlights the global impact of this issue. For TIC, the second most resistant antibiotic in our study in dogs and the first in cats, similar results have been found in other studies that showed around 50% of AMR [44,56,57].…”

Section: Discussionsupporting

confidence: 52%

Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region

Marco-Fuertes,

Jordá,

Marin

et al. 2023

Antibiotics

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Failure in antibiotic therapies due to the increase in antimicrobial-resistant (AMR) bacteria is one of the main threats to public and animal health. In recent decades, the perception of companion animals has changed, from being considered as a work tool to a household member, creating a family bond and sharing spaces in their daily routine. Hence, the aim of this study is to assess the current epidemiological situation regarding the presence of AMR and multidrug resistance (MDR) in companion animals in the Valencia Region, using the indicator bacteria Escherichia coli as a sentinel. For this purpose, 244 samples of dogs and cats were collected from veterinary centres to assess antimicrobial susceptibility against a panel of 22 antibiotics with public health relevance. A total of 197 E. coli strains were isolated from asymptomatic dogs and cats. The results showed AMR against all the 22 antibiotics studied, including those critically important to human medicine. Moreover, almost 50% of the strains presented MDR. The present study revealed the importance of monitoring AMR and MDR trends in companion animals, as they could pose a risk due to the spread of AMR and its resistance genes to humans, other animals and the environment they cohabit.

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Section: Discussionsupporting

confidence: 52%

Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region

Marco-Fuertes,

Jordá,

Marin

et al. 2023

Antibiotics

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“…Resistance rates are generally relatively high worldwide, reaching 50, 60%, or higher levels, depending on the antibiotic agent [14]. In Greece, rates of resistant E. coli strains have been detected in human patients, varying approximately between 20 and 45% for the different antibiotics [15].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic Resistant E. coli Strains Isolated from Farmed Broilers and Hens in Greece, Based on Phenotypic and Molecular Analyses

et al. 2023

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The use of antimicrobials is beneficial for livestock health; however, their overuse and misuse may increase resistance to these compounds. Thus, the aim of the present study was the phenotypic and molecular examination of the presence of Escherichia coli antibiotic-resistant strains in broiler and laying hen farms. The resistance of E. coli strains was examined against various antibiotics, including several families of compounds such as penicillin class medications (ampicillin), cephalosporins (cefotaxime, cefoxitin, cefpodoxime and ceftazidime), sulfonamides (co-trimoxazole), quinolones (enrofloxacin and nalidixic acid), aminoglycosides (gentamicin), β-lactams (imipenem), aminoglycoside (streptomycin), and polymyxin (colistin). In total, 106 strains were investigated, sampled during the years 2016–2019 from 91 poultry farms, including 75 broiler farms and 16 laying hen farms, originating from three Regional Units in Greece. The examined isolates revealed the highest resistance rates to sulfamethoxazole (81.1%), nalidixic acid (73.6%), tetracyclin (70.8%), and streptomycin (70.8%). On the other hand, the resistance of the isolates to third generation cephalosporins was found to be at lower levels for ceftazidime (2.8%), ceftriaxone (3.7%) cefoxitin (4.7%), and cefotaxime (4.7%). Phenotypic tests showed that 13.6% and 10.2% of the isolates produced ESBL, while 2.7% and 1% produced AmpC b-lactamase, for broiler and laying hens, respectively. The prevalence of the mcr-1 gene was found to be 22.7%, detected only in broiler isolates. Based on our results, E. coli antibiotic resistance represents a critical control point in poultry production that, apart from farm animals, may affect public health as well.

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“…This is in stark contrast to adult studies, where E. coli is the most commonly isolated bacterial pathogen in culture-positive community-onset sepsis, but the rates of ampicillin resistance are lower and in the 40-50% range. 30,31 Antimicrobial resistance was also similar in VLBW and non-VLBW infants, and we did not nd any relationship between ampicillin resistance and death, severe illness, or the composite outcome of either in our study. These data are reassuring, especially in the era of multi-drug resistant E. coli, drug shortages, and concern regarding the continued e cacy of ampicillin and gentamicin as rst-line empiric antibiotic therapy for EOS in neonates.…”

Section: Discussionmentioning

confidence: 48%

Predictors of Mortality and Severe Illness from Escherichia coli Sepsis in Neonates

Mukherjee,

Hoffman,

Satyavolu

et al. 2024

Preprint

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Background: Neonatal Escherichia coli (E. coli) sepsis is increasing. There is limited data on the factors which contribute to increased mortality and severity of illness in neonatal E. colisepsis. Methods: Retrospective review of neonates (<30 days) admitted to a Level IV NICU in the United States from 2008 to 2022 with a diagnosis of E. coli bloodstream or cerebrospinal fluid infection was conducted. Primary outcome was defined as mortality from or severe illness during E. coliinfection (defined as need for inotropic support or metabolic acidosis). Results: E. coli neonatal sepsis rate increased from 2008-2022 (average of 1.12 per 1,000 live births). The primary outcome, which occurred in 50% of cases, was independently associated with prematurity, neutropenia, and thrombocytopenia. Ampicillin resistance was not associated with the primary outcome. Conclusion: GA, neutropenia, and thrombocytopenia but not ampicillin resistance, are associated with mortality or severe illness from E. colisepsis.

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Antimicrobial resistance and mortality following E. coli bacteremia

Cited by 14 publications

References 14 publications

Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region

Multidrug-Resistant Escherichia coli Strains to Last Resort Human Antibiotics Isolated from Healthy Companion Animals in Valencia Region

Prevalence of Antibiotic Resistant E. coli Strains Isolated from Farmed Broilers and Hens in Greece, Based on Phenotypic and Molecular Analyses

Predictors of Mortality and Severe Illness from Escherichia coli Sepsis in Neonates

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