Antimicrobial Resistance and Medicinal Plant Products as Potential Alternatives to Antibiotics in Animal Husbandry

Reddy, Sagar Mallikethi Lepakshi; Barathe, Pramod; Kaur, Kawaljeet; Anand, Uttpal; Shriram, Varsha; Kumar, Vinay

doi:10.1007/978-981-16-3120-7_13

Cited by 6 publications

(2 citation statements)

References 112 publications

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“…Our study also identified AMR in E. coli isolated from flocks with no previous antimicrobial use history (e.g., tetracyclines and aminoglycosides resistance), stressing the importance of future studies to identify additional risk factors besides AMU (aspects of biosecurity including downtime/rest period, cleaning and disinfection and use of premise disinfectants) that impact the development of AMR. In addition, future studies should evaluate the effectiveness of antimicrobial alternatives (e.g., prebiotics, probiotics) (Brown et al, 2017;Fuhrmann et al, 2022;Reddy et al, 2022) to reduce the emergence of resistance to individual and multiple antimicrobial classes. This study methodology could be used to evaluate the AMU-AMR linkages in other animals as well as in humans.…”

Section: Discussionmentioning

confidence: 99%

Associations between antimicrobial resistance in fecal Escherichia coli isolates and antimicrobial use in Canadian turkey flocks

et al. 2022

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Antimicrobial resistance (AMR) in enteric bacteria continues to be detected in turkey flocks and retail products worldwide, including in Canada. However, studies assessing linkages between on-farm antimicrobial use (AMU) and the development of AMR are lacking. This study aims to identify AMU characteristics that impact the development of AMR in the indicator bacteria Escherichia coli in turkey flocks, building on the Canadian Integrated Program for Antimicrobial Resistance Surveillance methodology for farm-level AMU and AMR data integration. Two analytic approaches were used: (1) multivariable mixed-effects logistic regression models examined associations between AMU (any route, route-specific, and route-disease-specific indication) summarized as the number of defined daily doses in animals using Canadian standards ([nDDDvetCA]/1,000 kg-animal-days at risk) and AMR and (2) multivariable mixed-effects Poisson regression models studied the linkages between AMU and the number of classes to which an E. coli isolate was resistant (nCRE. coli). A total of 1,317 E. coli isolates from a network of 16 veterinarians and 334 turkey producers across the five major turkey-producing provinces in Canada between 2016 and 2019 were used. Analysis indicated that AMR emerged with the use of related antimicrobials (e.g., tetracycline use-tetracycline resistance), however, the use of unrelated antimicrobial classes was also impacting AMR (e.g., aminoglycosides/streptogramins use-tetracycline resistance). As for studying AMU-nCRE. coli linkages, the most robust association was between the parenteral aminoglycosides use and nCRE. coli, though in-feed uses of four unrelated classes (bacitracin, folate pathway inhibitors, streptogramins, and tetracyclines) appear to be important, indicating that ongoing uses of these classes may slow down the succession from multidrug-resistant to a more susceptible E. coli populations. The analysis of AMU (route and disease-specific)-AMR linkages complemented the above findings, suggesting that treatment of certain diseases (enteric, late-stage septicemic conditions, and colibacillosis) are influential in the development of resistance to certain antimicrobial classes. The highest variances were at the flock level indicating that stewardship actions should focus on flock-level infection prevention practices. This study added new insights to our understanding of AMU-AMR linkages in turkeys and is useful in informing AMU stewardship in the turkey sector. Enhanced surveillance using sequencing technologies are warranted to explain molecular-level determinants of AMR.

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Section: Discussionmentioning

confidence: 99%

Associations between antimicrobial resistance in fecal Escherichia coli isolates and antimicrobial use in Canadian turkey flocks

et al. 2022

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“…Among the alternatives explored for discovering new bioactive molecules with antimicrobial potential, medicinal plants occupy a special place. Indeed, several scientific studies have mentioned the hope raised by the use of medicinal plants for the discovery of new antimicrobials in both animals and humans [15] and in humans [16][17][18][19]. Some data in the literature have reported the antimicrobial potential of plants belonging to the family Apocynaceae [20].…”

Section: Introductionmentioning

confidence: 99%

A review of some medicinal plants with the potential to defeat antimicrobial resistance: Cases of Benin, Togo, Ghana, Burkina Faso, and Cape Verde

et al. 2022

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Antimicrobial resistance (AMR) is a global public health problem. In the alternatives being explored for developing new antimicrobials, medicinal plants occupy an important place, particularly in Africa, where they are widely used. This review aims to analyze the potential of medicinal plants from Benin, Togo, Ghana, Burkina-Faso, and Cape Verde in the fight against AMR. A bibliographic search was conducted to explore scientific databases such as PubMed and Google Scholar. During this search, particular attention was given to epidemiological data related to AMR in these countries, medicinal plants traditionally used to treat microbial infections and medicinal plants that have been shown to be active on multidrug-resistant microbial strains. In total, 94 manuscripts were investigated. Epidemiological data showed that the problem of AMR is worsening in each target country. In addition, several medicinal plants have been demonstrated to be effective against microbial strains resistant to conventional antibiotics. A total of 532 medicinal plants were identified according to their ethnomedical uses for the treatment of microbial infections. Scientific evidence was collected on the antimicrobial potential of 91 plants. This study showed the potential of medicinal plants in the fight against AMR. Their documented traditional use, coupled with the evidence of efficacy provided, make them interesting sources for developing new antimicrobials.

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Study on the adsorption of chlortetracycline in water on peanut shells decorated with magnetic particles by ultrasonic-assisted method

Yang,

An,

Han

et al. 2023

Biomass Conv. Bioref.

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Antimicrobial Resistance and Medicinal Plant Products as Potential Alternatives to Antibiotics in Animal Husbandry

Cited by 6 publications

References 112 publications

Associations between antimicrobial resistance in fecal Escherichia coli isolates and antimicrobial use in Canadian turkey flocks

Associations between antimicrobial resistance in fecal Escherichia coli isolates and antimicrobial use in Canadian turkey flocks

A review of some medicinal plants with the potential to defeat antimicrobial resistance: Cases of Benin, Togo, Ghana, Burkina Faso, and Cape Verde

Study on the adsorption of chlortetracycline in water on peanut shells decorated with magnetic particles by ultrasonic-assisted method

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