Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa

Qekwana, Daniel Nenene; Phophi, Lufuno; Naidoo, Vinny; Oguttu, James Wabwire; Odoi, Agricola

doi:10.1186/s12917-018-1552-7

Cited by 27 publications

(28 citation statements)

References 23 publications

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“…Similar to other works published in Europe, E. coli was the most frequently isolated bacterium in both cats and dogs, followed by Enterococcus spp. in cats 17 and P. mirabilis in dogs 2,10,18 . Although E. coli was the most common pathogen found in this study, the overall resistance frequencies of MDR isolates were low (8%) in comparison to other studies 10,18 .…”

Section: Discussioncontrasting

confidence: 46%

“…Antimicrobial agents such as amoxicillin‐clavulanic acid, trimethoprim/sulphamethoxazole, tetracycline, and cephalexin are reported to be effective against E. coli UTI 22 . In this study, the E. coli isolates from dogs and cats with UTI presented high levels of resistance to ampicillin, first‐generation cephalosporins (cephalothin and cephalexin) and doxycycline as previously described 18 . Moreover, 70% of E. coli strains in dogs showed resistance to cephalotin and around 40% in cats resist to cefepime (fourth‐generation cephalosporin).…”

Section: Discussionmentioning

confidence: 80%

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Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain

Darwich

Seminati

Burballa³

et al. 2021

Veterinary Record

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Background The increasing emergence of multidrug‐resistant bacteria, causing urinary tract infections (UTI) in dogs and cats, represents a great therapeutic challenge and a public health concern. Methods Laboratory records of 4943 urinary microbiological diagnosis results and antimicrobial resistance profiles of suspected UTI cases in dogs and cats were analysed from 2016 to 2018 in Spain. Results This study showed a higher percentage of positive microbiological diagnoses in dogs (42%, 1368/3270) than in cats (27%, 457/1673). Although Escherichia coli was the most frequently isolated bacterium, the frequency of antimicrobial susceptibility of E. coli isolates was lower compared to other bacterial species like Enterococcus spp., Staphylococcus spp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter (E. cloacae), and Proteus mirabilis. The antimicrobial susceptibility testing of Gram‐positive cocci showed higher levels of resistance in cats to common beta‐lactams used for the treatment of complicated UTIs, as well as to fluoroquinolones, aminoglycosides, and carbapenems. Moreover, enterobacteria (E. coli, K. pneumoniae, and P. mirabilis) from cats presented high resistance frequencies to beta‐lactams, including third‐ and fourth‐generation cephalosporins and fluoroquinolones. Conclusion This study updates data on the current antimicrobial resistance in UTI bacteria from companion animals in Spain, which may help to guide clinicians for the appropriate use of antimicrobials.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 80%

Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain

Darwich

Seminati

Burballa³

et al. 2021

Veterinary Record

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“…(the latter in the Enterobacteriaceae family), Enterococcus spp., Pseudomonas spp., and Streptococcus spp. [ 23 , 24 , 25 , 26 ]. The prevalence of resistance in E. coli was high (20–50%) to 11 antimicrobials, with only amikacin and florfenicol showing no resistance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Antimicrobial Resistance in Bacterial Isolates from Dogs and Cats in a Veterinary Diagnostic Laboratory in Colombia from 2016–2019

Gómez-Beltrán

Villar

López-Osorio

et al. 2020

Veterinary Sciences

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The susceptibility to antimicrobials of bacterial isolates from dogs (n = 1256) and cats (n = 94) was retrospectively evaluated in a veterinary diagnostic laboratory over a 4-year period (2016–2019). Out of 1316 isolates in dogs, 771 were Staphylococcus spp. distributed as follows: Staph. pseudointermedius (n = 406), Staph. intermedius (n = 160), Staph. aureus (n = 104), and Staph. coagulase-negative (n = 101). In common, all Staphylococcus spp. showed a high prevalence (20–50%) of resistance to ampicillin, cephalosporin, enrofloxacin, gentamicin, tetracycline, and trimethoprim-sulfonamide, but a low prevalence (1–10%) of resistance to amoxicillin-clavulanate. With regards to the other families of bacteria, the number of antimicrobials for which resistance was high (>20%) in dogs was: Enterobacteriaceae (7/12), Enterococcus spp. (10/16), E. coli (11/15), Pseudomonas spp. (10/13), and Streptococcus spp. (4/9). For urinary tract infections caused by E. coli or Enterobacteriaceae (Klebsiella spp., Proteus spp.), amikacin and florfenicol were the only drugs that demonstrated 100% in vitro efficacy. Multi-drug resistance was observed in 18.7% (246/1316) and 22% (21/97) of the isolates from dogs and cats, respectively. Except for Pseudomonas spp., known for intrinsic resistance, resistance in other bacteria was likely attributed to high selection pressure. In conclusion, empirical antimicrobial use cannot be recommended to treat most common infections, and selection should be based on results from susceptibility testing.

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“…Curiously, ciprofloxacin is a fluoroquinolone recommended for complicated infections and urinary tract infections (UTI) caused by MDR Gram-negative bacteria, such as E. coli [36]. Additionally, chloramphenicol and trimethoprim/sulfamethoxazole are also common choices for treatment of UTI and diarrhea associated with E. coli in humans and animals [36, 39, 40].…”

Section: Discussionmentioning

confidence: 99%

Identification and Characterization ofEscherichia coli,SalmonellaSpp.,Clostridium perfringens, andC. difficileIsolates from Reptiles in Brazil

Ramos

Santana

Coura

et al. 2019

BioMed Research International

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Considering the increasing popularity of reptiles as pets and their possible role as reservoirs of pathogenic microorganisms, the aim of this study was to isolate Escherichia coli, Salmonella spp., Clostridium perfringens, and C. difficile strains from reptiles in Brazil and to characterize the isolated strains. The characterization was based on phylogenetic typing of E. coli, identification of virulence genes of E. coli, C. perfringens, and C. difficile, serotyping of Salmonella spp., ribotyping and MLST of C. difficile and antimicrobial susceptibility test of pathogenic strains. Cloacal swabs were collected from 76 reptiles, of which 15 were lizards, 16 chelonians, and 45 snakes, either living in captivity, in the wild, or as companion animals. E. coli was isolated from 52 (68.4%) reptiles, of which 46 (88.4%) were characterized as phylogroup B1. The virulence factor CNF1 of E. coli was found in seven (9.2%) sampled animals, whereas the gene of EAST1 was found in isolates from two (2.6%) reptiles. Three isolates positive for CNF1 were resistant to cephalothin, one of which was also resistant to ciprofloxacin, trimethoprim/sulfamethoxazole, and chloramphenicol, being then classified as multidrug resistant strain (MDR). Salmonella enterica was identified in 26 (34.2%) reptiles, of which 13 belonged to the subspecies enterica. Serotypes such as S. Mbandaka, S. Panama, S. Infantis, S. Heidelberg, and S. Anatum were identified. One isolate of S. enterica subsp. houtenae was resistant to cephalothin and ciprofloxacin. C. perfringens type A was isolated from six (7.8%) animals. C. difficile was isolated from three (3.9%) reptiles. Two of these isolates were toxigenic and classified into ribotypes/MLST 081/ST9 and 106/ST42, which have been previously reported to infect humans. In conclusion, reptiles in Brazil can harbor toxigenic C. difficile and potentially pathogenic E. coli and Salmonella enterica subsp. enterica, thus representing a risk to human and animal health.

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Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa

Cited by 27 publications

References 23 publications

Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain

Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain

Prevalence of Antimicrobial Resistance in Bacterial Isolates from Dogs and Cats in a Veterinary Diagnostic Laboratory in Colombia from 2016–2019

Identification and Characterization ofEscherichia coli,SalmonellaSpp.,Clostridium perfringens, andC. difficileIsolates from Reptiles in Brazil

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